Protein Alignment Pkd2 and Pkd2l1

DIOPT Version :10

• Sequence 1: NP_609561.2
• Gene: Pkd2 / 34651
• FlyBaseID: FBgn0041195
• Length: 924
• Species: Drosophila melanogaster
• Sequence 2: NP_001402765.1
• Gene: Pkd2l1 / 293937
• RGDID: 1306261
• Length: 763
• Species: Rattus norvegicus
• Alignment Length: 896
• Identity: 250/896 - (27%)
• Similarity: 379/896 - (42%)
• Gaps: 235/896 - (26%)

  Fly    95 SPRPSLRDPGQSTSDKPSTSDKPSTSDKPSTSARTTVREPGPSSSPSRPVSTRESGRITFQEAAP 159
            |....|:..|....|.|:.|..||                 |:.:|          ||
  Rat     7 SKEQELQTLGSRVWDNPAYSSPPS-----------------PNGTP----------RI------- 37

  Fly   160 STSAKVVKLAASEPRPAKPPEKEGFSLFKRKKKSVGSSTPPSP--------SRGHRAPSIIAASA 216
               ..|..:|..|.:|.||.       .:|::|     ||..|        .||.|.   :..:.
  Rat    38 ---CTVSSVALPETQPKKPE-------VRRQEK-----TPRVPVSGCCLLICRGIRG---LWGTT 84

  Fly   217 LQNRAKTNRILYTTDEEVREALVEFSVFIIFLILTSLVVLSVRHTYMFYFNDTMKKLFTNREMVV 281
            |......||.||     |:..|.|..|:|:||:...|:...:..:..:|:...|.:||.:
  Rat    85 LTENTAENRELY-----VKTTLRELVVYIVFLVDVCLLTYGMTSSSAYYYTKVMSELFLH----- 139

  Fly   282 APSVT-VGFEKLITVPDWWDYLKYNFLVTLHGDLTFMDDAQANLTSMPPEGSEQGSEQGSEQGSE 345
            .||.: |.|:.:.::.|:||:
  Rat   140 TPSESAVSFQTISSMSDFWDF-------------------------------------------- 160

  Fly   346 QSPEEVVGEAPEEAPEMDRLQEDFKYNGNPYIDLRGHRRAKRQSGVDGNSEDGSEDVSGNYLKDD 410
                       .:.|.:|.|.....||                     |...||...|..|
  Rat   161 -----------AQGPLLDSLYWTKWYN---------------------NQSLGSSSHSFIY---- 189

  Fly   411 SDSIQANMSFHHLEGRVFLYENLLLGPPRLRQIRVRKESCYVNDAFIRYFNTCYAAYSSGAEDRK 475
                               |||||||.|||||:|||.:||.|::.|......||..||...||:.
  Rat   190 -------------------YENLLLGVPRLRQLRVRNDSCVVHEDFREDILNCYDVYSPDKEDQL 235

  Fly   476 PMH--KGS--PFRTMHDLDSTPIWTVLAFYRTGGYTVNLDYDKDRNVKIINDLKDIHWLDRGSRL 536
            |..  .|:  .:.:.::|..:..|..|..|..|||.::|...:..:.:.:..|::..|||||:|:
  Rat   236 PFGPLNGTAWTYHSQNELGGSSHWGRLTSYSGGGYYLDLPGSRQASAEALQGLQEGLWLDRGTRV 300

  Fly   537 CLVEFNLFNENTDIFQSIKLIAEIPPTGGVIPQAHLQTVKMYSFFTDRSMLMTVIYIFWYIMVIY 601
            ..::|:::|.|.::|..::|:.|.|.|||.||...::|||:..:..:....:....:.:.|.:.|
  Rat   301 VFIDFSVYNANINLFCILRLVVEFPATGGAIPSWQIRTVKLIRYVNNWDFFIVGCEVIFCIFIFY 365

  Fly   602 YTIYEITEIRKSGIKIYFCSMLNILDCAILLGCYLALVYNIWHSFKVMSLTAR-AHSDVTYQSLD 665
            |.:.||.|||....: |..|:.||||..::|...:|:.::::.:.:|..|... .....||...:
  Rat   366 YVVEEILEIRVHRFR-YLSSVWNILDLVVILLSIVAVGFHVFRTLEVNRLMGELLQQPDTYPDFE 429

  Fly   666 VLCFWNIIYVDMMAILAFLVWIKIFKFISFNKTLVQFTTTLKRCSKDLAGFSLMFGIVFLAYAQL 730
            .|.||...|.:|.|:..|..||||||:||||||:.|.::||.||:||:.||::||.|||.|||||
  Rat   430 FLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGFAIMFFIVFFAYAQL 494

  Fly   731 GLLLFGTKHPDFRNFITSILTMIRMILGDFQYNLIEQANRVLGPIYFLTYILLVFFILLNMFLAI 795
            |.|||||:...|..|:..|.|..|:|||||.||.|:.|||:|||:||:||:..|||:||||||||
  Rat   495 GYLLFGTQVESFSTFVKCIFTQFRIILGDFDYNAIDNANRILGPVYFITYVFFVFFVLLNMFLAI 559

  Fly   796 IMETYNTVKGEITQGRSHL-------GSY----------------IYRKLSG------------M 825
            |.:||:.||.|:...|..|       .||                :.:.|.|            .
  Rat   560 INDTYSEVKEELAGQRDQLQLSDLLKQSYSKTLQRLRLRKERVSDVQKVLKGGEPEIQFEDFTNT 624

  Fly   826 LYWITHCGRKRRHHPQASETEDKDAEH-----DVGAAHDETHEIRKNMTPAEQQYFKDI---PQG 882
            |..:.|..|:......|....|:|.:|     |.........|.|..::...:...:.:   |.|
  Rat   625 LRELGHAEREISEVSAAFTRFDRDGDHILDEEDQAQMRQGLEEERMTLSAETENLGRSVGHSPPG 689

  Fly   883 E-------------NQDMVRLNNRVGLLEEILEKLINNMDDI---LKRVEK 917
            |             .::...|..||..|:.:||.:::.:|.:   ||.:|:
  Rat   690 ELDAEAARGRSWVSGEEFDMLTRRVLQLQRVLEGVVSQVDALSSKLKMLER 740

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkd2	NP_609561.2	DUF5585	<29..272	CDD:465521	41/184 (22%)
		Polycystin_dom	404..578	CDD:466668	58/177 (33%)
		PKD_channel	579..803	CDD:462341	101/224 (45%)
Pkd2l1	NP_001402765.1	Polycystin_dom	147..342	CDD:466668	71/293 (24%)
		PKD_channel	343..567	CDD:462341	101/224 (45%)
		YhaN	569..>745	CDD:443752	30/172 (17%)
		Fer4_24	702..735	CDD:436280	7/32 (22%)