Protein Alignment Pkd2 and Pkd2l2

DIOPT Version :10

• Sequence 1: NP_609561.2
• Gene: Pkd2 / 34651
• FlyBaseID: FBgn0041195
• Length: 924
• Species: Drosophila melanogaster
• Sequence 2: XP_063133288.1
• Gene: Pkd2l2 / 291683
• RGDID: 1310272
• Length: 623
• Species: Rattus norvegicus
• Alignment Length: 729
• Identity: 209/729 - (28%)
• Similarity: 327/729 - (44%)
• Gaps: 162/729 - (22%)

  Fly   228 YTTDEEVREALVEFSVFIIFLILTSLVVLSVRHTYMFYFNDTMKKLFTNREMVVAPSVTVGFEKL 292
            |..:.||...|.|..::.||||...::.....:.:|:|.|..|..||.:..:  .......|..:
  Rat    21 YRREAEVNTTLEELLLYFIFLINLCILTFGTVNPHMYYLNKVMSSLFVDTSL--PDDERSSFRSI 83

  Fly   293 ITVPDWWDYLKYNFLVTLHGDLTFMDDAQANLTSMPPEGSEQGSEQGSEQGSEQSPEEVVGEAPE 357
            .::.::|.::
  Rat    84 RSITEFWKFM------------------------------------------------------- 93

  Fly   358 EAPEMDRLQEDFKYNGNPYIDLRGHRRAKRQSGVDGNSEDGSEDVSGNYLKDDSDSIQANMSFHH 422
            |.|.::.|..|..| ||..:|                           .:|:.|
  Rat    94 EGPLVEGLYWDSWY-GNTQLD---------------------------SVKNSS----------- 119

  Fly   423 LEGRVFLYENLLLGPPRLRQIRVRKESCYVNDAFIRYFNTCYAAYSSGAEDRKPMHKGSPFRTMH 487
                :..|||:|||.||:||:|||..:|.|..||....:.||..|::..||      .|.|...|
  Rat   120 ----LIYYENILLGVPRVRQLRVRNSTCQVYPAFQSLASDCYNKYTAENED------FSDFGLKH 174

  Fly   488 DLD---STPI------WTVLAFYRTGGYTVNLDYDKDRNVKIINDLKDIHWLDRGSRLCLVEFNL 543
            |.:   |.|.      |..:..||.|||.|.|...|......:.||:..:|:.||:|...::|:|
  Rat   175 DPEWRHSAPSSTAPWHWGFVGVYRDGGYMVTLSKSKSETKAKLADLRQNNWIGRGTRAVFIDFSL 239

  Fly   544 FNENTDIFQSIKLIAEIPPTGGVIPQAHLQTVKMYSFFTDRSMLMTVIYIFWY---------IMV 599
            :|.|.::|..|:|:||.|.|||::......:||:            :.|:.:|         |..
  Rat   240 YNANVNLFCIIRLLAEFPATGGILTSWQFYSVKL------------IRYVSYYDHFIASCEIIFC 292

  Fly   600 IYYTIYEITEIRKSG--IKIYFCSMLNILDCAILLGCYLALVYNIWHSFKVMSLTAR-AHSDVTY 661
            |:..::...|:||..  ...||.|:.|.::..:|:.|:||:.:..:.:.:...|..: ..|..:|
  Rat   293 IFLLVFITQELRKLNEFKSAYFRSVWNWIELLLLVLCFLAVSFYAYCNVQCFLLLGQLLRSTESY 357

  Fly   662 QSLDVLCFWNIIYVDMMAILAFLVWIKIFKFISFNKTLVQFTTTLKRCSKDLAGFSLMFGIVFLA 726
            .....|.:|:|.|.:::||..|..|||||||||||:|:.|.::||.||.||:.||::||.|:|.|
  Rat   358 PDFYFLAYWHIYYNNIIAITIFFAWIKIFKFISFNETMSQLSSTLSRCMKDIVGFAIMFFIIFFA 422

  Fly   727 YAQLGLLLFGTKHPDFRNFITSILTMIRMILGDFQYNLIEQANRVLGPIYFLTYILLVFFILLNM 791
            ||||..|:||::..||..|..||....|::||||.:..|:|||.:||||||:|:|..|||:||||
  Rat   423 YAQLAFLVFGSQVDDFSTFQNSIFAQFRIVLGDFNFAGIQQANWILGPIYFITFIFFVFFVLLNM 487

  Fly   792 FLAIIMETYNTVKGEITQGRS---HLGSYIYRKLSGMLYWITHCGRKRRHHPQASETEDKDAEHD 853
            |||||.:||:.||.:.:.||.   .|||.|.:....:|..:    |.|:    |...|||..:..
  Rat   488 FLAIINDTYSEVKADYSIGRRPDFELGSIIKKSCFNILEKL----RLRK----AQNNEDKKMKTS 544

  Fly   854 VGAAH-----------DETHEIRKNMTPAEQQYFKDIPQGENQDMVRLNNRVGLLEEI-LEKLIN 906
            |..|.           .|..::::.....|::|:....|.:.|.:.:...|...|..: |||.::
  Rat   545 VDLAQARKEGFDESEIQEARQMKRWKERLEKKYYSTEIQDDYQPVTQQEFRELFLYAVELEKELH 609

  Fly   907 NMDDILKRVEKDYH 920
            .:...|.:|.:..|
  Rat   610 YLSLKLNQVMRKLH 623

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkd2	NP_609561.2	DUF5585	<29..272	CDD:465521	13/43 (30%)
		Polycystin_dom	404..578	CDD:466668	60/182 (33%)
		PKD_channel	579..803	CDD:462341	94/235 (40%)
Pkd2l2	XP_063133288.1	None