Protein Alignment Pkd2 and Pkd2l2

DIOPT Version :9

• Sequence 1: NP_609561.2
• Gene: Pkd2 / 34651
• FlyBaseID: FBgn0041195
• Length: 924
• Species: Drosophila melanogaster
• Sequence 2: NP_001099626.1
• Gene: Pkd2l2 / 291683
• RGDID: 1310272
• Length: 621
• Species: Rattus norvegicus
• Alignment Length: 740
• Identity: 211/740 - (28%)
• Similarity: 333/740 - (45%)
• Gaps: 164/740 - (22%)

  Fly   219 NRAKTNR--ILYTTDEEVREALVEFSVFIIFLILTSLVVLSVRHTYMFYFNDTMKKLFTNREMVV 281
            :|..|::  :.|..:.||...|.|..::.||||...::.....:.:|:|.|..|..||.:..:
  Rat     8 HRGGTSKHDLHYRREAEVNTTLEELLLYFIFLINLCILTFGTVNPHMYYLNKVMSSLFVDTSL-- 70

  Fly   282 APSVTVGFEKLITVPDWWDYLKYNFLVTLHGDLTFMDDAQANLTSMPPEGSEQGSEQGSEQGSEQ 346
            .......|..:.::.::|.::
  Rat    71 PDDERSSFRSIRSITEFWKFM-------------------------------------------- 91

  Fly   347 SPEEVVGEAPEEAPEMDRLQEDFKYNGNPYIDLRGHRRAKRQSGVDGNSEDGSEDVSGNYLKDDS 411
                       |.|.::.|..|..| ||..:|                           .:|:.|
  Rat    92 -----------EGPLVEGLYWDSWY-GNTQLD---------------------------SVKNSS 117

  Fly   412 DSIQANMSFHHLEGRVFLYENLLLGPPRLRQIRVRKESCYVNDAFIRYFNTCYAAYSSGAEDRKP 476
                           :..|||:|||.||:||:|||..:|.|..||....:.||..|::..||
  Rat   118 ---------------LIYYENILLGVPRVRQLRVRNSTCQVYPAFQSLASDCYNKYTAENED--- 164

  Fly   477 MHKGSPFRTMHDLD---STPI------WTVLAFYRTGGYTVNLDYDKDRNVKIINDLKDIHWLDR 532
               .|.|...||.:   |.|.      |..:..||.|||.|.|...|......:.||:..:|:.|
  Rat   165 ---FSDFGLKHDPEWRHSAPSSTAPWHWGFVGVYRDGGYMVTLSKSKSETKAKLADLRQNNWIGR 226

  Fly   533 GSRLCLVEFNLFNENTDIFQSIKLIAEIPPTGGVIPQAHLQTVKMYSFFTDRSMLMTVIYIFWY- 596
            |:|...::|:|:|.|.::|..|:|:||.|.|||::......:||:            :.|:.:|
  Rat   227 GTRAVFIDFSLYNANVNLFCIIRLLAEFPATGGILTSWQFYSVKL------------IRYVSYYD 279

  Fly   597 --------IMVIYYTIYEITEIRKSG--IKIYFCSMLNILDCAILLGCYLALVYNIWHSFKVMSL 651
                    |..|:..::...|:||..  ...||.|:.|.::..:|:.|:||:.:..:.:.:...|
  Rat   280 HFIASCEIIFCIFLLVFITQELRKLNEFKSAYFRSVWNWIELLLLVLCFLAVSFYAYCNVQCFLL 344

  Fly   652 TAR-AHSDVTYQSLDVLCFWNIIYVDMMAILAFLVWIKIFKFISFNKTLVQFTTTLKRCSKDLAG 715
            ..: ..|..:|.....|.:|:|.|.:::||..|..|||||||||||:|:.|.::||.||.||:.|
  Rat   345 LGQLLRSTESYPDFYFLAYWHIYYNNIIAITIFFAWIKIFKFISFNETMSQLSSTLSRCMKDIVG 409

  Fly   716 FSLMFGIVFLAYAQLGLLLFGTKHPDFRNFITSILTMIRMILGDFQYNLIEQANRVLGPIYFLTY 780
            |::||.|:|.|||||..|:||::..||..|..||....|::||||.:..|:|||.:||||||:|:
  Rat   410 FAIMFFIIFFAYAQLAFLVFGSQVDDFSTFQNSIFAQFRIVLGDFNFAGIQQANWILGPIYFITF 474

  Fly   781 ILLVFFILLNMFLAIIMETYNTVKGEITQGRS---HLGSYIYRKLSGMLYWITHCGRKRRHHPQA 842
            |..|||:|||||||||.:||:.||.:.:.||.   .|||.|.:....:|..:    |.|:    |
  Rat   475 IFFVFFVLLNMFLAIINDTYSEVKADYSIGRRPDFELGSIIKKSCFNILEKL----RLRK----A 531

  Fly   843 SETEDKDAEHDVGAAH-----------DETHEIRKNMTPAEQQYFKDIPQGENQDMVRLNNRVGL 896
            ...|||..:..|..|.           .|..::::.....|::|:....|.:.|.:.:...|...
  Rat   532 QNNEDKKMKTSVDLAQARKEGFDESEIQEARQMKRWKERLEKKYYSTEIQDDYQPVTQQEFRELF 596

  Fly   897 LEEI-LEKLINNMDDILKRVEKDYH 920
            |..: |||.::.:...|.:|.:..|
  Rat   597 LYAVELEKELHYLSLKLNQVMRKLH 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkd2	NP_609561.2	PKD_channel	402..803	CDD:285288	154/421 (37%)
Pkd2l2	NP_001099626.1	PKD_channel	76..497	CDD:285288	164/536 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345344
Domainoid	1	1.000	313	1.000	Domainoid score	I1256
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	356	1.000	Inparanoid score	I2162
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D205541at33208
OrthoFinder	1	1.000	-	-		FOG0002518
OrthoInspector	1	1.000	-	-		otm44805
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10877
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1653
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.860