Protein Alignment Pkd2 and PKD2L2

DIOPT Version :9

• Sequence 1: NP_609561.2
• Gene: Pkd2 / 34651
• FlyBaseID: FBgn0041195
• Length: 924
• Species: Drosophila melanogaster
• Sequence 2: NP_001287850.1
• Gene: PKD2L2 / 27039
• HGNCID: 9012
• Length: 624
• Species: Homo sapiens
• Alignment Length: 739
• Identity: 209/739 - (28%)
• Similarity: 331/739 - (44%)
• Gaps: 156/739 - (21%)

  Fly   203 SRGHRAPSIIAASALQNRAKTNRILYTTDEEVREALVEFSVFIIFLILTSLVVLSVRHTYMFYFN 267
            ||.||           ..|..:::.|..:.|:...|.|..::.||||...::...:.:.:|:|.|
Human     5 SRWHR-----------GGASKHKLHYRKEVEITTTLQELLLYFIFLINLCILTFGMVNPHMYYLN 58

  Fly   268 DTMKKLFTNREMVVAPSVTVGFEKLITVPDWWDYLKYNFLVTLHGDLTFMDDAQANLTSMPPEGS 332
            ..|..||.:..  |.......|:.:.::.|:|.::
Human    59 KVMSSLFLDTS--VPGEERTNFKSIRSITDFWKFM------------------------------ 91

  Fly   333 EQGSEQGSEQGSEQSPEEVVGEAPEEAPEMDRLQEDFKYNGNPYIDLRGHRRAKRQSGVDGNSED 397
                                     |.|.::.|..|..||.....:|:...|
Human    92 -------------------------EGPLLEGLYWDSWYNNQQLYNLKNSSR------------- 118

  Fly   398 GSEDVSGNYLKDDSDSIQANMSFHHLEGRVFLYENLLLGPPRLRQIRVRKESCYVNDAFIRYFNT 462
                                          ..|||:|||.||:||::||..:|.|..:|....:.
Human   119 ------------------------------IYYENILLGVPRVRQLKVRNNTCKVYSSFQSLMSE 153

  Fly   463 CYAAYSSGAEDRK--PMHKGSPFRTMHDLDSTP-IWTVLAFYRTGGYTVNLDYDKDRNVKIINDL 524
            ||..|:|..||..  .:...:.:|......::| .|..|..||.|||...|...|........||
Human   154 CYGKYTSANEDLSNFGLQINTEWRYSTSNTNSPWHWGFLGVYRNGGYIFTLSKSKSETKNKFIDL 218

  Fly   525 KDIHWLDRGSRLCLVEFNLFNENTDIFQSIKLIAEIPPTGGVIPQAHLQTVKMYSFFTDRSMLMT 589
            :...|:.||:|:..::|:|:|.|.::|..|:|:||.|.|||::......:||:..:.:.....:.
Human   219 RLNSWITRGTRVIFIDFSLYNANVNLFCIIRLVAEFPATGGILTSWQFYSVKLLRYVSYYDYFIA 283

  Fly   590 VIYIFWYIMVIYYTIYEITEIR--KSGIKIYFCSMLNILDCAILLGCYLALVYNIWHSFKVMSLT 652
            ...|.:.|.:..:|..|:.:|:  ||.   ||.|:.|.|:..:||.|::|:.:|.:::.::..|.
Human   284 SCEITFCIFLFVFTTQEVKKIKEFKSA---YFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLL 345

  Fly   653 AR-AHSDVTYQSLDVLCFWNIIYVDMMAILAFLVWIKIFKFISFNKTLVQFTTTLKRCSKDLAGF 716
            .: ..|...|.....|..|:|.|.:::||..|..|||||||||||||:.|.::||.||.||:.||
Human   346 GQLLKSTEKYSDFYFLACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVGF 410

  Fly   717 SLMFGIVFLAYAQLGLLLFGTKHPDFRNFITSILTMIRMILGDFQYNLIEQANRVLGPIYFLTYI 781
            ::||.|:|.||||||.|:||::..||..|..||....|::||||.:..|:|||.:||||||:|:|
Human   411 AIMFFIIFFAYAQLGFLVFGSQVDDFSTFQNSIFAQFRIVLGDFNFAGIQQANPILGPIYFITFI 475

  Fly   782 LLVFFILLNMFLAIIMETYNTVKGEITQGRS---HLGSYIYRKLSGMLYWITHCGRKRRHHPQAS 843
            ..|||:|||||||||.:||:.||.:.:.||.   .||..|.:....:|        ::....:|.
Human   476 FFVFFVLLNMFLAIINDTYSEVKADYSIGRRLDFELGKMIKQSYKNVL--------EKFRLKKAQ 532

  Fly   844 ETEDKD-------AEHDVGAAHDE-----THEIRKNMTPAEQQYFKDIPQGENQDMVRLNNRVGL 896
            :.|||.       ||.......||     ..:::|.....|::|:....|.:.|.:.:
Human   533 KDEDKKTKGSGDLAEQARREGFDENEIQNAEQMKKWKERLEKKYYSMEIQDDYQPVTQ------- 590

  Fly   897 LEEILEKLINNMDDILKRVEKDYH 920
             ||..|..:..::     :||:.|
Human   591 -EEFRELFLYAVE-----LEKELH 608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkd2	NP_609561.2	PKD_channel	402..803	CDD:285288	151/406 (37%)
PKD2L2	NP_001287850.1	PKD_channel	76..497	CDD:332708	162/521 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151827
Domainoid	1	1.000	307	1.000	Domainoid score	I1352
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	352	1.000	Inparanoid score	I2268
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D205541at33208
OrthoFinder	1	1.000	-	-		FOG0002518
OrthoInspector	1	1.000	-	-		otm40667
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10877
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1653
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.860