DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkd2 and Pkdrej

DIOPT Version :9

Sequence 1:	NP_609561.2	Gene:	Pkd2 / 34651	FlyBaseID:	FBgn0041195	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_035235.2	Gene:	Pkdrej / 18766	MGIID:	1338786	Length:	2126	Species:	Mus musculus

Alignment Length:	734	Identity:	145/734 - (19%)
Similarity:	251/734 - (34%)	Gaps:	245/734 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   212 IAASALQNRAKTNRILYTTDEEVREALVEFSVFI---IFLILTSLVVLSVRHTYMFYFNDTMKKL 273
            |....:|...:.|||.       |.:.:..|..:   |||.|..|::.|:||...||:|..::..
Mouse  1562 ITEDKIQILRRENRIR-------RRSFLFLSYLVTHFIFLTLLLLLIFSLRHNDSFYYNQFIRHR 1619

  Fly   274 FTNREMVVAPSVTVGFEKLITVPDWWDYLKYNFLVTLHGDLTFMDDAQANLTSMPPEGSEQGSEQ 338
            |           :|....::.:.|.:.:|...||..||.|
Mouse  1620 F-----------SVDLATVMKLGDIYTWLHGVFLPLLHND------------------------- 1648

  Fly   339 GSEQGSEQSPEEVVGEAPEEAPEMDRLQEDFKYNGNPYIDLRGHRRAKRQSGVDGNSEDGSEDVS 403
                                              .||
Mouse  1649 ----------------------------------PNP---------------------------- 1651

  Fly   404 GNYLKDDSDSIQANMSFHHLEGRVFLYENLLLGPPRLRQIRVR--KESCYVNDAFIRYFNT---- 462
             .:|.|.|..|                    ||.|.:||:|.|  .::|.:...|::....
Mouse  1652 -TFLPDSSSKI--------------------LGLPLVRQVRARPSNKTCLLAKKFVQSSVAGEIH 1695

  Fly   463 CYAAYSSGAEDRKPMH---------KGSPFRTMHDLDSTP---IWT-----VLAFYRTGGY---- 506
            |:..|....||.:  |         |.|..:..|.....|   .|.     ||..|.:|||
Mouse  1696 CHPQYGIDPEDTQ--HYSSVWSKAGKQSTDKASHGFTYKPPGKRWVYHSYGVLNTYGSGGYVFYF 1758

  Fly   507 ---------TVNLDYDKDRNVKIINDLKDIHWLDRGSRLCLVEFNLFNENTDIFQSIKLIAEIPP 562
                     ||.|           .:|:..:|||..:...:||....|.:|.:..||.::.|:.|
Mouse  1759 FPGQQMFNSTVRL-----------KELEGKNWLDELTWAVIVELTTLNPDTSLMCSISVVFEVSP 1812

  Fly   563 TGGVIPQAHLQTVKMYSF----FTDRSMLMTVIYIFWYIMVIY--YTI---YEITEIRKSGIKIY 618
            .|.|     ..::.:|||    |..::  .:.||::..|::.:  |.:   |.|.:.|.|    |
Mouse  1813 LGVV-----NSSLSVYSFSLADFNRKT--SSEIYLYAAILIFFCAYVVDEGYIIRQERAS----Y 1866

  Fly   619 FCSMLNILDCAILLGCYLALVYNIWHSFKVMSLTARAHSDVTYQSLDVLCFWNIIYVD--MMAIL 681
            ..|:.|:|:.::.....|.:|...|..|....:.....:|..    ..:.|..:..||  |..||
Mouse  1867 IRSVYNLLNFSLKCMFALLIVLFFWKYFLATKMVQLYLADPE----AFIPFHAVSRVDHFMRIIL 1927

  Fly   682 AFLVWIKIFKFISFNKTLVQFTTTLKRCSKDLAGF---SLMFGIVFLAYAQLGLLLFGTKHPDFR 743
            |||:::.|.|.:.:::.........|.....|.|.   :|:..|....|...|.|:||....::.
Mouse  1928 AFLLFLTILKTLRYSRFFYNVRLAQKAIQAALPGICHTALVVSIYSFMYVAFGYLVFGQHEWNYS 1992

  Fly   744 NFITSILTMIRMILGDFQYNLIEQANRVLGPIYFLTYILLVFFILLNMFLAIIMETYNTVKGEIT 808
            |.|.:..|:....:..|| |.....|:|||.::..:::|::..|.:|:|.|:|:..|:.:|..:.
Mouse  1993 NMIHATQTIFSYCVSAFQ-NTEFSGNKVLGVLFLSSFMLVMICIFINLFQAVILSAYDEMKQPVY 2056

  Fly   809 Q---GRSHLGSYIYRKLSGMLYWITHCGRKRRHHPQASETEDKDAEHDVGAAHDETHEIRKNMTP 870
            :   ..:...:|:..:|.....::|            :.:.|||
Mouse  2057 EEPSDEAEAVTYLCNRLKSGFDFLT------------TRSRDKD--------------------- 2088

  Fly   871 AEQQYFKDIPQGENQDMVR 889
             :..:|.|:..|:.:...|
Mouse  2089 -QSNFFVDMLYGQPEKNTR 2106

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkd2	NP_609561.2	PKD_channel	402..803	CDD:285288	105/450 (23%)
Pkdrej	NP_035235.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..71
		REJ	130..598	CDD:280229
		PLAT_polycystin	1115..1230	CDD:238850
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1379..1431
		PKD_channel	1621..2051	CDD:285288	115/566 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841949
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740