DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkd2 and pkd-2

DIOPT Version :9

Sequence 1:	NP_609561.2	Gene:	Pkd2 / 34651	FlyBaseID:	FBgn0041195	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_502838.3	Gene:	pkd-2 / 178424	WormBaseID:	WBGene00004035	Length:	716	Species:	Caenorhabditis elegans

Alignment Length:	838	Identity:	205/838 - (24%)
Similarity:	334/838 - (39%)	Gaps:	233/838 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 SSPSRPVSTRESGRITFQEAAPSTSAKVVKLAASEPRPAKPPEKEGFSLFKRKKKSVGSSTPPSP 202
            ::|.:||:..|.|        ||....:|.......:...|.:|||.|..:....|
Worm    11 ANPPQPVAAAEHG--------PSFDHSMVSEEYEHDKKKNPAQKEGISFSQALLAS--------- 58

  Fly   203 SRGHRAPSIIAASALQNRAKTNRILYTTDEEVR---EALVEFSVFIIFLILTSLVVLSVRHTYMF 264
              ||.                     .:|.:::   .:.:|...:.:|||:...|..:......:
Worm    59 --GHE---------------------KSDGKIKLTARSFMEVGGYAVFLIVLVYVAFAQNSIQSY 100

  Fly   265 YFNDTMKKLFTNREMVVAPSVTVG---FEKLITVPDWWDYLKYNFLVTLHGDLTFMDDAQANLTS 326
            |::..|..||      ||.:...|   |....::.:.||:|
Worm   101 YYSKVMSDLF------VASTGASGAPAFGSCTSMDNIWDWL------------------------ 135

  Fly   327 MPPEGSEQGSEQGSEQGSEQSPEEVVGEAPEEAPEMDRLQEDFKYNGNPYIDLRGHRRAKRQSGV 391
                                  .:|:
Worm   136 ----------------------SQVL--------------------------------------- 139

  Fly   392 DGNSEDGSEDVSGNYLKDDSDSI-QANMSFHHLEGRVFLYENLLLGPPRLRQIRVRKESCYVNDA 455
                      :.|.|..:.|:|. ..||.:         |||.|||.||:|.::|..:||.|..:
Worm   140 ----------IPGIYWTETSNSTDNENMIY---------YENRLLGEPRIRMLKVTNDSCTVMKS 185

  Fly   456 FIRYFNTCYAAYSSGAEDRKPMHKGSP----FRTMHDLDSTPIWTVLAFYRTGGYTVNLDYDKDR 516
            |.|....|:|.|....||:..:..||.    :.|..:|::......:|.|..||:...|......
Worm   186 FQREIKECFANYEEKLEDKTMVGDGSVDAFIYATAKELENLKTVGTIASYGGGGFVQRLPVAGST 250

  Fly   517 NVK-IINDLKDIHWLDRGSRLCLVEFNLFNENTDIFQSIKLIAEIPPTGGVIPQAHLQTVKMYSF 580
            ..: .|..||...|:|||||..:|:|.|:|.|.::|..:||:.|:|.:||||....|.|..:.::
Worm   251 EAQSAIATLKANRWIDRGSRAIIVDFALYNANINLFCVVKLLFELPASGGVITTPKLMTYDLLTY 315

  Fly   581 FTDRSMLMTVIYIFWYIMVIYYTIYEITEIRKSGIKIYFCSMLNILDCAILLGCYLALV------ 639
            .|.....|.:....:...::|:...|:..|.:..:. |.....|::| .:|||..:|.:
Worm   316 QTSGGTRMMIFEGIFCGFILYFIFEELFAIGRHRLH-YLTQFWNLVD-VVLLGFSVATIILSVNR 378

  Fly   640 ----YNIWHSFKVMSLTARAHSDVTYQSLDVLCFWNIIYVDMMAILAFLVWIKIFKFISFNKTLV 700
                .|..:|.....||.....|||.....        |:::.|.:.|:.|:|:|||||.|||:.
Worm   379 TKTGVNRVNSVIENGLTNAPFDDVTSSENS--------YLNIKACVVFVAWVKVFKFISVNKTMS 435

  Fly   701 QFTTTLKRCSKDLAGFSLMFGIVFLAYAQLGLLLFGTKHPDFRNFITSILTMIRMILGDFQYNLI 765
            |.::||.|.:||:.||::||.:.|.|:||.|.|.|||:..|:.|...|...::|:|||||.::.:
Worm   436 QLSSTLTRSAKDIGGFAVMFAVFFFAFAQFGYLCFGTQIADYSNLYNSAFALLRLILGDFNFSAL 500

  Fly   766 EQANRVLGPIYFLTYILLVFFILLNMFLAIIMETYNTVKGEITQGRSHLGSYIYRKLSGMLYWIT 830
            |..||..||.:|:.|:..|.|||||||||||.::|..||.|:.:.:..         .|:|.|..
Worm   501 ESCNRFFGPAFFIAYVFFVSFILLNMFLAIINDSYVEVKAELARKKDG---------EGILDWFM 556

  Fly   831 HCGR---KRRHHPQA----SETEDKD--------AEHDVG------------------AAHDETH 862
            :..|   ||...|.|    :..||..        ||.|:.                  .|.|...
Worm   557 NKVRGLTKRGKRPDAPGEDATYEDYKLMLYRAGYAEKDINEAFTRFNVTSMTEHVPEKVAEDIAD 621

  Fly   863 EIRKNMTPAEQQYFKDIPQGENQDMVRLNNRVGLLEEILEKLINNMDDI---LKRVEK 917
            |:.: ||..::.|.::     ::|...||.||..::|.:..:::.::.:   |:.:||
Worm   622 EVAR-MTEQKRNYMEN-----HRDYANLNRRVDQMQESVFSIVDRIEGVNATLQTIEK 673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkd2	NP_609561.2	PKD_channel	402..803	CDD:285288	140/416 (34%)
pkd-2	NP_502838.3	PKD_channel	119..538	CDD:285288	145/532 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161928
Domainoid	1	1.000	231	1.000	Domainoid score	I1383
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	240	1.000	Inparanoid score	I2105
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D205541at33208
OrthoFinder	1	1.000	-	-		FOG0002518
OrthoInspector	1	1.000	-	-		oto19419
orthoMCL	1	0.900	-	-		OOG6_103020
Panther	1	1.100	-	-	LDO	PTHR10877
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2725
SonicParanoid	1	1.000	-	-		X1653
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790