Protein Alignment Pkd2 and lov-1

DIOPT Version :10

• Sequence 1: NP_609561.2
• Gene: Pkd2 / 34651
• FlyBaseID: FBgn0041195
• Length: 924
• Species: Drosophila melanogaster
• Sequence 2: NP_496184.3
• Gene: lov-1 / 174576
• WormBaseID: WBGene00003058
• Length: 3284
• Species: Caenorhabditis elegans
• Alignment Length: 845
• Identity: 158/845 - (18%)
• Similarity: 300/845 - (35%)
• Gaps: 242/845 - (28%)

  Fly   144 VSTRESGRITFQEAAPSTSAKVVKLAASEPRPAKPPEKEGFSLFKRKKKSVGSSTPPSPSRGHRA 208
            :.||:|.:|            :.||..:..| |||.|....:.:.:.:|.:|:          ..
 Worm  2612 LKTRKSHKI------------INKLEEALLR-AKPAETFLRNPYGKIEKGLGT----------EI 2653

  Fly   209 PSIIAASALQNRAKTNRILYTTDEEVREALVEFSVFIIFLILTSLVVLSVRHTYMF------YFN 267
            ..:......:||...:..|:.|   :|:.|..|:...|.::||  .....||.|.:      ..|
 Worm  2654 ADVTKLRDTENRKMRDEQLFIT---IRDMLCFFASLYIMVMLT--YYCKDRHGYWYQLEMSTILN 2713

  Fly   268 DTMKKLFTNREMVVAPSVTVGFEKLITVPDWWDYLKYNFLVTLHGDLTFMDDAQANLTSMPPEGS 332
            ...|....|.           |..:....|:||:.:.:.             |.|.|.|.
 Worm  2714 INQKNYGDNT-----------FMSIQHADDFWDWARESL-------------ATALLASW----- 2749

  Fly   333 EQGSEQGSEQGSEQSPEEVVGEAPEEAPEMDRLQEDFKYNGNPYIDLRGHRRAKRQSGVDGNSED 397
                                                  |:|||...:|.:.
 Worm  2750 --------------------------------------YDGNPAYGMRAYM-------------- 2762

  Fly   398 GSEDVSGNYLKDDSDSIQANMSFHHLEGRVFLYENLLLGPPRLRQIRVRKES-CYVNDAFIRYFN 461
                         :|.:..:|                 |...:||:|.:|.: |.:...|..|.|
 Worm  2763 -------------NDKVSRSM-----------------GIGTIRQVRTKKSAECTMFKQFQGYIN 2797

  Fly   462 TCYAAYSSGAEDRK-PMHKG---------------SPFRTMHDLDSTPIWTVLAFYRTGGYTVNL 510
            .|....:|..|::. .|..|               ..::|..:|.:..:..:|..|..||||:::
 Worm  2798 DCGEELTSKNEEKTLYMQAGWTELESENGTDASDEYTYKTSEELSTETVSGLLYSYSGGGYTISM 2862

  Fly   511 DYDKDRNVKIINDLKDIHWLDRGSRLCLVEFNLFNENTDIFQSIKLIAEIPPTGGVIPQAHLQTV 575
            ...:...:.:.|.|....|:|..:|..::||:.:|...:.|..::|:.|||.:|..:|.:.:::|
 Worm  2863 SGTQAEIITLFNKLDSERWIDDHTRAVIIEFSAYNAQINYFSVVQLLVEIPKSGIYLPNSWVESV 2927

  Fly   576 KMY-SFFTDRSML--MTVIYIFWYIMV----IYYTIY----EITEIR--KSGIKIYF------CS 621
            ::. |..:|.:::  ..::|||:.:::    |.:.:|    .||.::  ::..||.:      .|
 Worm  2928 RLIKSEGSDGTVVKYYEMLYIFFSVLIFVKEIVFYLYGRYKVITTMKPTRNPFKIVYQLALGNFS 2992

  Fly   622 MLNILDCAI-LLGCYLALVYNIWHSFKVMSLTARAHSDV------TYQSLDVLCFWNIIYVDMMA 679
            ..|.:|..: .|.....|.|.|     ....|.||..|.      :|.:|.....|.|::...:|
 Worm  2993 PWNFMDLIVGALAVASVLAYTI-----RQRTTNRAMEDFNANNGNSYINLTEQRNWEIVFSYCLA 3052

  Fly   680 ILAFLVWIKIFKFISFNKTLVQFTTTLKRCSKDLAGFSLMFGIVFLAYAQ-LGLLLF---GTKHP 740
            ...|....|:.:.:.||:.:.....||    .:..|..:.|||.||.::. ...:|:   |.|..
 Worm  3053 GAVFFTSCKMIRILRFNRRIGVLAATL----DNALGAIVSFGIAFLFFSMTFNSVLYAVLGNKMG 3113

  Fly   741 DFRNFITSILTMIRMILGDFQYNLIEQANRVLGPIYFLTYILLVFF------ILLNMFLAIIMET 799
            .:|:.:.:..|.:..:||......|:       ||....:::::.:      ::|.:::.|||..
 Worm  3114 GYRSLMATFQTALAGMLGKLDVTSIQ-------PISQFAFVVIMLYMIAGSKLVLQLYVTIIMFE 3171

  Fly   800 YNTVKGEITQGRS------HLGSYIYRKLSGMLYWITHCGRKRRHHPQASETEDKDAE--HDVGA 856
            :..::.:..:..:      |: .|..::..|:|       ..:...|.:.....||..  |...|
 Worm  3172 FEEIRNDSEKQTNDYEIIDHI-KYKTKRRLGLL-------EPKDFAPVSIADTQKDFRLFHSAVA 3228

  Fly   857 AHDETHEIRKNMTPAEQQYFKDIPQGENQDMVRLN---NRVGLLEEILEKLINNMDDILKRVEKD 918
            ..:..|.....|...:.||       :||.::...   :.|..:.|...|......  |..||||
 Worm  3229 KVNLLHHRATRMLQTQGQY-------QNQTVINYTLSYDPVSAIHETGPKRFQKWR--LNDVEKD 3284

  Fly   919  918
             Worm  3285  3284

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkd2	NP_609561.2	DUF5585	<29..272	CDD:465521	27/133 (20%)
		Polycystin_dom	404..578	CDD:466668	40/190 (21%)
		PKD_channel	579..803	CDD:462341	53/258 (21%)
lov-1	NP_496184.3	GPS	2177..2226	CDD:197639
		PLAT_polycystin	2288..2413	CDD:238850
		Polycystin_dom	2724..2930	CDD:466668	53/305 (17%)
		PKD_channel	2992..3175	CDD:462341	42/198 (21%)