DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkd2 and lov-1

DIOPT Version :9

Sequence 1:	NP_609561.2	Gene:	Pkd2 / 34651	FlyBaseID:	FBgn0041195	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_496184.3	Gene:	lov-1 / 174576	WormBaseID:	WBGene00003058	Length:	3284	Species:	Caenorhabditis elegans

Alignment Length:	845	Identity:	158/845 - (18%)
Similarity:	300/845 - (35%)	Gaps:	242/845 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 VSTRESGRITFQEAAPSTSAKVVKLAASEPRPAKPPEKEGFSLFKRKKKSVGSSTPPSPSRGHRA 208
            :.||:|.:|            :.||..:..| |||.|....:.:.:.:|.:|:          ..
Worm  2612 LKTRKSHKI------------INKLEEALLR-AKPAETFLRNPYGKIEKGLGT----------EI 2653

  Fly   209 PSIIAASALQNRAKTNRILYTTDEEVREALVEFSVFIIFLILTSLVVLSVRHTYMF------YFN 267
            ..:......:||...:..|:.|   :|:.|..|:...|.::||  .....||.|.:      ..|
Worm  2654 ADVTKLRDTENRKMRDEQLFIT---IRDMLCFFASLYIMVMLT--YYCKDRHGYWYQLEMSTILN 2713

  Fly   268 DTMKKLFTNREMVVAPSVTVGFEKLITVPDWWDYLKYNFLVTLHGDLTFMDDAQANLTSMPPEGS 332
            ...|....|.           |..:....|:||:.:.:.             |.|.|.|.
Worm  2714 INQKNYGDNT-----------FMSIQHADDFWDWARESL-------------ATALLASW----- 2749

  Fly   333 EQGSEQGSEQGSEQSPEEVVGEAPEEAPEMDRLQEDFKYNGNPYIDLRGHRRAKRQSGVDGNSED 397
                                                  |:|||...:|.:.
Worm  2750 --------------------------------------YDGNPAYGMRAYM-------------- 2762

  Fly   398 GSEDVSGNYLKDDSDSIQANMSFHHLEGRVFLYENLLLGPPRLRQIRVRKES-CYVNDAFIRYFN 461
                         :|.:..:|                 |...:||:|.:|.: |.:...|..|.|
Worm  2763 -------------NDKVSRSM-----------------GIGTIRQVRTKKSAECTMFKQFQGYIN 2797

  Fly   462 TCYAAYSSGAEDRK-PMHKG---------------SPFRTMHDLDSTPIWTVLAFYRTGGYTVNL 510
            .|....:|..|::. .|..|               ..::|..:|.:..:..:|..|..||||:::
Worm  2798 DCGEELTSKNEEKTLYMQAGWTELESENGTDASDEYTYKTSEELSTETVSGLLYSYSGGGYTISM 2862

  Fly   511 DYDKDRNVKIINDLKDIHWLDRGSRLCLVEFNLFNENTDIFQSIKLIAEIPPTGGVIPQAHLQTV 575
            ...:...:.:.|.|....|:|..:|..::||:.:|...:.|..::|:.|||.:|..:|.:.:::|
Worm  2863 SGTQAEIITLFNKLDSERWIDDHTRAVIIEFSAYNAQINYFSVVQLLVEIPKSGIYLPNSWVESV 2927

  Fly   576 KMY-SFFTDRSML--MTVIYIFWYIMV----IYYTIY----EITEIR--KSGIKIYF------CS 621
            ::. |..:|.:::  ..::|||:.:::    |.:.:|    .||.::  ::..||.:      .|
Worm  2928 RLIKSEGSDGTVVKYYEMLYIFFSVLIFVKEIVFYLYGRYKVITTMKPTRNPFKIVYQLALGNFS 2992

  Fly   622 MLNILDCAI-LLGCYLALVYNIWHSFKVMSLTARAHSDV------TYQSLDVLCFWNIIYVDMMA 679
            ..|.:|..: .|.....|.|.|     ....|.||..|.      :|.:|.....|.|::...:|
Worm  2993 PWNFMDLIVGALAVASVLAYTI-----RQRTTNRAMEDFNANNGNSYINLTEQRNWEIVFSYCLA 3052

  Fly   680 ILAFLVWIKIFKFISFNKTLVQFTTTLKRCSKDLAGFSLMFGIVFLAYAQ-LGLLLF---GTKHP 740
            ...|....|:.:.:.||:.:.....||    .:..|..:.|||.||.::. ...:|:   |.|..
Worm  3053 GAVFFTSCKMIRILRFNRRIGVLAATL----DNALGAIVSFGIAFLFFSMTFNSVLYAVLGNKMG 3113

  Fly   741 DFRNFITSILTMIRMILGDFQYNLIEQANRVLGPIYFLTYILLVFF------ILLNMFLAIIMET 799
            .:|:.:.:..|.:..:||......|:       ||....:::::.:      ::|.:::.|||..
Worm  3114 GYRSLMATFQTALAGMLGKLDVTSIQ-------PISQFAFVVIMLYMIAGSKLVLQLYVTIIMFE 3171

  Fly   800 YNTVKGEITQGRS------HLGSYIYRKLSGMLYWITHCGRKRRHHPQASETEDKDAE--HDVGA 856
            :..::.:..:..:      |: .|..::..|:|       ..:...|.:.....||..  |...|
Worm  3172 FEEIRNDSEKQTNDYEIIDHI-KYKTKRRLGLL-------EPKDFAPVSIADTQKDFRLFHSAVA 3228

  Fly   857 AHDETHEIRKNMTPAEQQYFKDIPQGENQDMVRLN---NRVGLLEEILEKLINNMDDILKRVEKD 918
            ..:..|.....|...:.||       :||.::...   :.|..:.|...|......  |..||||
Worm  3229 KVNLLHHRATRMLQTQGQY-------QNQTVINYTLSYDPVSAIHETGPKRFQKWR--LNDVEKD 3284

Fly 919 918
Worm 3285 3284

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkd2	NP_609561.2	PKD_channel	402..803	CDD:285288	93/453 (21%)
lov-1	NP_496184.3	GPS	2177..2226	CDD:197639
		PLAT_polycystin	2288..2413	CDD:238850
		PKD_channel	2723..3175	CDD:285288	106/578 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770