Protein Alignment Pkd2 and Pkd1l1

DIOPT Version :9

• Sequence 1: NP_609561.2
• Gene: Pkd2 / 34651
• FlyBaseID: FBgn0041195
• Length: 924
• Species: Drosophila melanogaster
• Sequence 2: XP_036013024.1
• Gene: Pkd1l1 / 171395
• MGIID: 2156538
• Length: 2551
• Species: Mus musculus
• Alignment Length: 644
• Identity: 116/644 - (18%)
• Similarity: 222/644 - (34%)
• Gaps: 201/644 - (31%)

  Fly   201 SPSRGHRAPSIIAA---------SALQNRAKTNRILYTTDEEVRE------ALVEFSVFIIFLIL 250
            ||.....|..::|.         :...::||    |..|.|.:|.      ||.:.:...|.|:|
Mouse  1932 SPDTAEEAERVLATRQRERHLRWAQTPSKAK----LRVTGERLRRESIMQAALRDMTTHSIMLLL 1992

  Fly   251 TSLVV--------LSVRHTYMFYFNDTMKKLFTNREMVVAPSVTVGFEKLITVPDWWDYLKYNFL 307
            ...:.        :|:.|        .::|.||.:     .:.::|  .|.:..||||:
Mouse  1993 LLFIAYGRFCPGEISLNH--------AIRKAFTRK-----ANHSLG--DLSSTEDWWDW------ 2036

  Fly   308 VTLHGDLTFMDDAQANLTSMPPEGSEQGSEQGSEQGSEQSPEEVVGEAPEEAPEMDRLQEDFKYN 372
             ||.   |.:|:.....||....|::.|:
Mouse  2037 -TLS---TLLDELYPERTSARAWGAQPGA------------------------------------ 2061

  Fly   373 GNPYIDLRGHRRAKRQSGVDGNSEDGSEDVSGNYLKDDSDSIQANMSFHHLEGRVFLYENLLLGP 437
                                                              |.|:..     |:||
Mouse  2062 --------------------------------------------------LGGQCH-----LIGP 2071

  Fly   438 PRLRQIRVRK-ESCYVNDAFIRYFNTCYAAYSSGAEDRKPMHKGSPFRTMHDLD-----STPIWT 496
            |.::.:::.. .:|           |....:|...||..|||.       :|||     .:|...
Mouse  2072 PVVKLLKISAGTAC-----------TPPRPFSELVEDVLPMHS-------NDLDLENQNVSPGGP 2118

  Fly   497 VLAFYRTGGYTVNLDYDKDRNVKIINDLKDIHWLDRGSRLCLVEFNLFNENTDIFQSIKLIAEIP 561
            .....:...|..:|...:......:..|:...|:|..:|...|.|.|:|..|.:|.|:.|..|..
Mouse  2119 ETCGVKKESYMHSLGKTRHEAHAALTALRASKWIDHSTRAMSVHFTLYNPPTQLFTSVILGTECL 2183

  Fly   562 PTGGVIPQAHLQTVKMYSFFTDRSM--LMTVIYIFWYIMVIYYTIYEITEIRKSGIKIYFCSMLN 624
            |:||::|...:::.::  |::|.::  |:.:..:.:.::.:.:..:::..:...||..|:....:
Mouse  2184 PSGGLVPSFLVESFRI--FYSDSALKYLLMLSELLFLVLNVIHLCFQLWGMTTKGILSYWRKPRH 2246

  Fly   625 ILDCAILLGCYLALVYNIWH-SFKVMSLTARAHSDVTYQSLDV--LCFWNIIYVDMMAILAFLVW 686
            .|:.: ::|..:|......| :...:::|.:.|..:..:.:|:  :..|:.....:..||.||..
Mouse  2247 WLELS-MVGVAIAYYAASGHLTTLAVNITDQFHKGLYQRLVDIGLMVSWHQRARCLQGILLFLWM 2310

  Fly   687 IKIFKFISFNKTLVQFTTT----LKRCSKDLAGFSLMFGIVFLA--YAQLGLLLF------GTKH 739
            :|....:|...|:..|:..    |.|.        |:.|.:.||  |.....|||      ||..
Mouse  2311 LKYVHLLSSLSTMTPFSAVTCFPLFRV--------LLVGALLLAAHYHSRWFLLFTGTLSHGTSA 2367

  Fly   740 PDFRNFITSILTMIRMILGDFQYNLIEQANRVLGPIYFLTYILLV---FFILLNMFLAI 795
            ..|...:.......:.   |..:|.::..:.|:...|...::||.   |.:|...||.:
Mouse  2368 EAFPGLLLQFPGRSKK---DSWHNCLKSDHGVMRCYYGTLFLLLATLGFRMLRATFLTV 2423

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkd2	NP_609561.2	PKD_channel	402..803	CDD:285288	82/420 (20%)
Pkd1l1	XP_036013024.1	PCC	<167..622	CDD:188093
		REJ	<835..976	CDD:366875
		GPS	1387..1425	CDD:413374
		PLAT	1493..1611	CDD:412108
		PKD_channel	2023..>2331	CDD:400395	73/431 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841947
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740