Protein Alignment Pkd2 and PKD1L1

DIOPT Version :9

• Sequence 1: NP_609561.2
• Gene: Pkd2 / 34651
• FlyBaseID: FBgn0041195
• Length: 924
• Species: Drosophila melanogaster
• Sequence 2: XP_016867287.1
• Gene: PKD1L1 / 168507
• HGNCID: 18053
• Length: 2920
• Species: Homo sapiens
• Alignment Length: 852
• Identity: 156/852 - (18%)
• Similarity: 270/852 - (31%)
• Gaps: 324/852 - (38%)

  Fly   144 VSTRESGRITFQEAA--PSTSAKVVKLAASEP-----RPAKPPEKEGFSLFKRKKKSVGSSTPPS 201
            ::.|...|:.|..:.  |..:.:|.|:.|:..     |.|.||.|                   :
Human  2279 LAERSWTRLPFSSSCSIPDCAGEVEKVLAARQQARHLRWAHPPSK-------------------A 2324

  Fly   202 PSRGHRAPSIIAASALQNRAKTNRILYTTDEEVREALVEFSVFIIFLILTSLVVLSVRHTYMFYF 266
            ..||.|          |...:.:|        .|.||.:.|:.|:.|:|...|:........:..
Human  2325 QLRGTR----------QRMRRESR--------TRAALRDISMDILMLLLLLCVIYGRFSQDEYSL 2371

  Fly   267 NDTMKKLFTNREMVVAPSVTVGFEKLITVPDWWDYLKYNFLVTLHGDLTFMDDAQANLTSMPPEG 331
            |..::|.||..    |.:...|   |..:.||||:    .|.||             |..:.|.|
Human  2372 NQAIRKEFTRN----ARNCLGG---LRNIADWWDW----SLTTL-------------LDGLYPGG 2412

  Fly   332 SEQGSEQGSEQGSEQSPEEVVGEAPEEAPEMDRLQEDFKYNGNPYIDLRGHRRAKRQSGVDGNSE 396
            :......|::.|:
Human  2413 TPSARVPGAQPGA---------------------------------------------------- 2425

  Fly   397 DGSEDVSGNYLKDDSDSIQANMSFHHLEGRVFLYENLLLGPPRLRQIRVRKESCYVNDAFIRYFN 461
                                      |.|:.:     |:|...:||::|          |.|:.
Human  2426 --------------------------LGGKCY-----LIGSSVIRQLKV----------FPRHL- 2448

  Fly   462 TCYAAYSSGAEDRKPMHKGSPFRTMHDLDSTPIWTVLAFYRTGG----YTVNLDYDKDRNVKI-- 520
             |           ||..   ||..:.: ||.|..:.    ..||    |.::   .:::||.:
Human  2449 -C-----------KPPR---PFSALIE-DSIPTCSP----EVGGPENPYLID---PENQNVTLNG 2490

  Fly   521 ------------------------INDLKDIHWLDRGSRLCLVEFNLFNENTDIFQSIKLIAEIP 561
                                    ::.|:...|:||.:|...|.|.|:|..|.:|.|:.|..||.
Human  2491 PGGCGTREDCVLSLGRTRTEAHTALSRLRASMWIDRSTRAVSVHFTLYNPPTQLFTSVSLRVEIL 2555

  Fly   562 PTGGVIPQAHLQTVKMYSFFTDRSM----LMTVIYIFWYIMVIYYTIYEITEIRKSGIKIYFCSM 622
            |||.::|.:   .|:.:|.|...|.    ||....:|..:.:|:..: ::..:...|:..|:...
Human  2556 PTGSLVPSS---LVESFSIFRSDSALQYHLMLPQLVFLALSLIHLCV-QLYRMMDKGVLSYWRKP 2616

  Fly   623 LNILDCAILLGCYLALVYNIWHSFKVMSLTARAHSDVT----------YQSLDVLCFWNIIYVDM 677
            .|.|:.:::   .::|.|     :.|.........|||          :..|.::..||.....:
Human  2617 RNWLELSVV---GVSLTY-----YAVSGHLVTLAGDVTNQFHRGLCRAFMDLTLMASWNQRARWL 2673

  Fly   678 MAILAFLVWIKIFKFISFNKTLVQFTTTLKRCSKDLAGFSLMFGIVFLAYAQLGLLLF------- 735
            ..||.||..:|.........|:...::.::.....:....|:..::..|.:.|...|.
Human  2674 RGILLFLFTLKCVYLPGIQNTMASCSSMMRHSLPSIFVAGLVGALMLAALSHLHRFLLSMWVLPP 2738

  Fly   736 GTKHPDFRNFITSILTMIRMILGDFQYNLIEQANRVLG---------PIYFLTYILLVF-----F 786
            ||    |.:....:|         |.:....|.:.:||         ..||  .|||:.     |
Human  2739 GT----FTDAFPGLL---------FHFPRRSQKDCLLGLSKSDQRAMACYF--GILLIVSATLCF 2788

  Fly   787 ILLNMFLAIIMETYNTVKGEITQGRSHLGSYIYRKLSGMLYWITHCGRKRRHHPQASETEDKDAE 851
            .:|..||..:.:...:.:.:.......:.:|::.|:...|         |...|:..|.|
Human  2789 GMLRGFLMTLPQKRKSFQSKSFVRLKDVTAYMWEKVLTFL---------RLETPKLEEAE----- 2839

  Fly   852 HDVGAAHDETHEIRKNMTPAEQQYFKDIPQGENQDMVRLNNRVGLLEEILEKLINNMDDILK--R 914
                  ..|.|           .|:             |:....||:|:|.| ||.:.|.|:  .
Human  2840 ------MVENH-----------NYY-------------LDEFANLLDELLMK-INGLSDSLQLPL 2873

  Fly   915 VEKDYHN 921
            :||..:|
Human  2874 LEKTSNN 2880

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkd2	NP_609561.2	PKD_channel	402..803	CDD:285288	89/465 (19%)
PKD1L1	XP_016867287.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151824
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740