DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pkd2 and LOXHD1

DIOPT Version :9

Sequence 1:	NP_609561.2	Gene:	Pkd2 / 34651	FlyBaseID:	FBgn0041195	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_001371403.1	Gene:	LOXHD1 / 125336	HGNCID:	26521	Length:	2273	Species:	Homo sapiens

Alignment Length:	158	Identity:	34/158 - (21%)
Similarity:	55/158 - (34%)	Gaps:	46/158 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   296 PDWW-DYLKYNFLVTLHGDLTFMDDA------------------QANL---------TSMPPEGS 332
            |.|: |.:....||....|||..::|                  :|.|         :....||.
Human   889 PSWFVDTVWLRHLVVREVDLTPEEEARKKKEKDKLRQLLKKERLKAKLQRKKKKRKGSDEEDEGE 953

  Fly   333 EQGSEQGSEQGSEQSPEEVVGEAPEEAPEMDRLQEDFKYNGNPYIDLRGHRRAKRQS-------- 389
            |:.|....|..||:...|...|..|..|.|..:.|..|:..:.::     .|.|..:
Human   954 EEESSSSEESSSEEEEMEEEEEEEEFGPGMQEVIEQHKFEAHRWL-----ARGKEDNELVVELVP 1013

  Fly   390 ----GVDGNSEDGSEDVSGNYLKDDSDS 413
                |.:.|:.: .:.|:||..|..:|:
Human  1014 AGKPGPERNTYE-VQVVTGNVPKAGTDA 1040

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkd2	NP_609561.2	PKD_channel	402..803	CDD:285288	5/12 (42%)
LOXHD1	NP_001371403.1	PLAT_repeat	44..162	CDD:238854
		PLAT_repeat	172..289	CDD:238854
		PLAT_repeat	296..414	CDD:238854
		PLAT_repeat	425..542	CDD:238854
		PLAT_repeat	554..675	CDD:238854
		PLAT_repeat	684..805	CDD:238854
		PLAT	816..>896	CDD:412108	3/6 (50%)
		PLAT_repeat	1022..1142	CDD:238854	6/20 (30%)
		PLAT_repeat	1175..1295	CDD:238854
		PLAT_repeat	1306..1432	CDD:238854
		PLAT_repeat	1460..1580	CDD:238854
		PLAT	1629..1744	CDD:412108
		PLAT_repeat	1758..1875	CDD:238854
		PLAT_repeat	1885..2005	CDD:238854
		PLAT	2018..2119	CDD:412108
		PLAT_repeat	2154..2272	CDD:238854
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900