Protein Alignment Pkd2 and PKD1L2

DIOPT Version :10

• Sequence 1: NP_609561.2
• Gene: Pkd2 / 34651
• FlyBaseID: FBgn0041195
• Length: 924
• Species: Drosophila melanogaster
• Sequence 2: NP_443124.4
• Gene: PKD1L2 / 114780
• HGNCID: 21715
• Length: 2463
• Species: Homo sapiens
• Alignment Length: 905
• Identity: 197/905 - (21%)
• Similarity: 330/905 - (36%)
• Gaps: 221/905 - (24%)

  Fly    20 PRPPKTP-PGASPRGTPTADSTPGDVTPARGP------PPPPATKRVSIGVGSTRSA---PPPA- 73
            ||..|.. .|...||:|       ::||:..|      .|...||.||..|.|...|   |.||
Human  1617 PRVAKEQNTGKWDRGSP-------NLTPSPQPMEDGLLTPEAVTKDVSRIVSSLFKALKVPSPAL 1674

  Fly    74 -----------------TDPTGPPPTAGKPVRDTGPSTSPRPSLRDP-----GQSTSDKPSTSDK 116
                             .|...|..|:|:...:.....      .||     |.|...:.|...|
Human  1675 GWDSVNLMDINSLLALVEDVIYPQNTSGQVFWEEAKKR------EDPVTLTLGSSEMKEKSQCPK 1733

  Fly   117 PSTSDKPSTSARTTVREPGPSSSPSRPVSTRESGRITFQEAAPSTSAKVVKLAASEPRPAKPPEK 181
            |.       :||         |.|.:..:.|:...:..:....       :|....||....|..
Human  1734 PK-------AAR---------SGPWKDSAYRQCLYLQLEHVEQ-------ELRLVGPRGFSQPHS 1775

  Fly   182 EGFSLFKRKKKSVGSSTPPSPSRGHRAPSIIAASALQNRAKTNRILYTTDEEVREALVEFSVFII 246
            ...:|.:.:....|....|    |..||:  .|||||            ..:..:.|..:.:.:.
Human  1776 HAQALRQLQTLKGGLGVQP----GTWAPA--HASALQ------------VSKPPQGLPWWCILVG 1822

  Fly   247 FLIL--TSLVVLSVRHTYMFYFND--------TMKKLFTNREMVVAPSVTVGFEKLITVPDWWDY 301
            :|::  ||.|.......|..::..        :|...|.....|..|...:||.....:.
Human  1823 WLLVAATSGVAAFFTMLYGLHYGRASSLRWLISMAVSFVESMFVTQPLKVLGFAAFFALV----- 1882

  Fly   302 LKYNFLVTLHGDLTFMDDAQANLTSMPPEGSEQG--------SEQGSEQGSEQSP-----EEVVG 353
                        |..:||.:..:..:|  |...|        :.:.|.:...|.|     |::..
Human  1883 ------------LKRVDDEEDTVAPLP--GHLLGPDPYALFRARRNSSRDVYQPPLTAAIEKMKT 1933

  Fly   354 EAPEEAPEMDRLQEDFKYNG--------------------NPYIDLRGHRRAKRQSGVDGNSEDG 398
            ...:|......::|...|.|                    |.::.   |...:..|||.|..|
Human  1934 THLKEQKAFALIREILAYLGFLWMLLLVAYGQRDPSAYHLNRHLQ---HSFTRGFSGVLGFRE-- 1993

  Fly   399 SEDVSGNYLKDDSDSIQANMSFHHLEGRVFLYENLLLGPPRLRQIRVRKESCYVNDAFIRYFNTC 463
                   :.|..:.::.:|: :.|..|.:....:.|:|..::||:||::.||.:......|.|.|
Human  1994 -------FFKWANTTLVSNL-YGHPPGFITDGNSKLVGSAQIRQVRVQESSCPLAQQPQAYLNGC 2050

  Fly   464 YAAYSSGAED---------RKPMHKGSPF------RTMHDLDSTPIWTVLAFYRTGGYTVNLDYD 513
            .|.||..|||         ...:..||.|      ::.......|||..|..||.|||.|.|..|
Human  2051 RAPYSLDAEDMADYGEGWNATTLSNGSSFPQAWQYQSQDQRQGYPIWGKLTVYRGGGYVVPLGTD 2115

  Fly   514 KDRNVKIINDLKDIHWLDRGSRLCLVEFNLFNENTDIFQSIKLIAEIPPTGGVIPQAHLQTVKMY 578
            :....:|:..|.|..|||..:|...||..::|.|.::|..:.|..|....|.....|.||::::|
Human  2116 RQSTSRILRYLFDNTWLDALTRAVFVESTVYNANVNLFCIVTLTLETSALGTFFTHAALQSLRLY 2180

  Fly   579 SFFTDRSMLMTVIYIFWYIMVIYYTIYEITEIRKS--GIKIYFCSMLNILDCAILLGCYLALVYN 641
            .|.......:....:.:::.::||.:.:...:.|.  |   ||||..|:|:.||:|..:.||...
Human  2181 PFTDGWHPFVVAAELIYFLFLLYYMVVQGKRMSKETWG---YFCSKWNLLELAIILASWSALAVF 2242

  Fly   642 IWHSFKV----------------MSLTARAHSDVTYQSLDVLCFWNIIYVDMMAILAFLVWIKIF 690
            :..:...                .|.||.|.:.:.|               ::|.|..|..:|::
Human  2243 VKRAVLAERDLQRCRNHREEGISFSETAAADAALGY---------------IIAFLVLLSTVKLW 2292

  Fly   691 KFISFNKTLVQFTTTLKRCSKDLAGFSLMFGIVFLAYAQLGLLLFGTKHPDFRNFITSILTMIRM 755
            ..:..|..:...|..|:|...|::||.::...:.|||:....|:||.|...::....:..||:.:
Human  2293 HLLRLNPKMNMITAALRRAWGDISGFMIVILTMLLAYSIASNLIFGWKLRSYKTLFDAAETMVSL 2357

  Fly   756 ILGDFQYNLIEQANRVLGPIYFLTYILLVFFILLNMFLAIIMETYN--------TVKGEI 807
            .||.|.|..:...:.|||.....:.|:.:.|::||:|:::|:..::        :.:|||
Human  2358 QLGIFNYEEVLDYSPVLGSFLIGSCIVFMTFVVLNLFISVILVAFSEEQKYYQLSEEGEI 2417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pkd2	NP_609561.2	DUF5585	<29..272	CDD:465521	55/284 (19%)
		Polycystin_dom	404..578	CDD:466668	54/188 (29%)
		PKD_channel	579..803	CDD:462341	54/249 (22%)
PKD1L2	NP_443124.4	CLECT	28..153	CDD:214480
		Gal_Rha_Lectin_PKD1L2	157..253	CDD:438688
		REJ	<581..898	CDD:366875
		GPS	1277..1316	CDD:470616
		GPS. /evidence=ECO:0000255|PROSITE-ProRule:PRU00098	1279..1326
		PLAT_polycystin	1387..1506	CDD:238850
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1622..1646		7/30 (23%)
		Polycystin_dom	1984..2180	CDD:466668	59/205 (29%)
		PKD_channel	2182..2404	CDD:462341	54/239 (23%)
		Channel pore-region	2344..2366		6/21 (29%)
		Interaction with GNAS and GNAI1. /evidence=ECO:0000269|PubMed:15203210	2383..2463		9/35 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2435..2463