DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkd2 and PKDREJ

DIOPT Version :9

Sequence 1:	NP_609561.2	Gene:	Pkd2 / 34651	FlyBaseID:	FBgn0041195	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_006062.1	Gene:	PKDREJ / 10343	HGNCID:	9015	Length:	2253	Species:	Homo sapiens

Alignment Length:	799	Identity:	171/799 - (21%)
Similarity:	300/799 - (37%)	Gaps:	238/799 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 SDKPSTSDKPSTSAR---TTVREPGPSSSPSRPVSTRESGRITFQEAAPSTSAKVVKLAASEPRP 175
            ::||......|.|.:   |.:|..|....|      .|..||..|         :|::..:  |.
Human  1638 TNKPKYCKNLSWSTKYKYTEIRLDGMRMHP------EEMQRIHDQ---------IVRIRGT--RM 1685

  Fly   176 AKPPEKEGFSLFKRKKKSVGSSTPPSPSRGHRAPSIIAASALQNRAKTNRILYTTDEEVREALVE 240
            .:|..::...:|||||                            |.|...:|:     :...|..
Human  1686 YQPLTEDEIRIFKRKK----------------------------RIKRRALLF-----LSYILTH 1717

  Fly   241 FSVFIIFLILTSLVVLSVRHTYMFYFNDTMKKLFTNREMVVAPSVTVGFEKLITVPDWWDYLKYN 305
            |    |||.|..::::.:|||..||:|..::..|:   |.:| :||    ||..:..|   |...
Human  1718 F----IFLALLLILIVLLRHTDCFYYNQFIRDRFS---MDLA-TVT----KLEDIYRW---LNSV 1767

  Fly   306 FLVTLHGDL--TFMDDAQANLTSMPPEGSEQGSEQGSEQGSEQSPEEVVGEAPEEAPEMDRLQED 368
            .|..||.||  ||:.::.:.:..:|.          ..|...:|.|::...|           |.
Human  1768 LLPLLHNDLNPTFLPESSSKILGLPL----------MRQVRAKSSEKMCLPA-----------EK 1811

  Fly   369 FKYNGNPYIDLRGHRRAKRQSGVDGNSEDGSEDVSGNYLKDDSDSI--QANMSFHHLEGRVFLYE 431
            |..|     .:|.......:.|:|  .|| :::.||.:.:.|..:|  ..|...:..:|..:||
Human  1812 FVQN-----SIRREIHCHPKYGID--PED-TKNYSGFWNEVDKQAIDESTNGFTYKPQGTQWLY- 1867

  Fly   432 NLLLGPPRLRQIRVRKESCYVNDAFIRYFNTCYAAYSSGAEDRKPMHKGSPFRTMHDLDSTPIWT 496
                                               ||.|
Human  1868 -----------------------------------YSYG-------------------------- 1871

  Fly   497 VLAFYRTGGYTVNLDYDKDR--NVKIINDLKDIHWLDRGSRLCLVEFNLFNENTDIFQSIKLIAE 559
            :|..|.:|||.:....::.|  :...:.:|::.:|||..:...::|...||.:.::|.||.:|.|
Human  1872 LLHTYGSGGYALYFFPEQQRFNSTLRLKELQESNWLDEKTWAVVLELTTFNPDINLFCSISVIFE 1936

  Fly   560 IPPTGGVIPQAHLQTVKMYSFFTDRSMLMTVIYIFWYIMVIY--YTIYE---ITEIRKSGIKIYF 619
            :...|.|.....|.:..:..|  ||. ....||::..|::.:  |.:.|   |.:.|.|    |.
Human  1937 VSQLGVVNTSISLHSFSLADF--DRK-ASAEIYLYVAILIFFLAYVVDEGCIIMQERAS----YV 1994

  Fly   620 CSMLNILDCAILLGCYLALVYNIWHSFKVMSLTARAHSDVT-----YQS--LDVLCFWNIIYVD- 676
            .|:.|:|:.|      |..::.:     ::.|..|.|...|     |.|  .|.:.|..:..||
Human  1995 RSVYNLLNFA------LKCIFTV-----LIVLFLRKHFLATGIIRFYLSNPEDFIPFHAVSQVDH 2048

  Fly   677 -MMAILAFLVWIKIFKFISFNKTLVQFTTTLKRCSKDLAG---FSLMFGIVFLAYAQLGLLLFGT 737
             |..||.||:::.|.|.:.:::.........:.....|.|   .:.:..:.|..|...|.|:||.
Human  2049 IMRIILGFLLFLTILKTLRYSRFFYDVRLAQRAIQAALPGICHMAFVVSVYFFVYMAFGYLVFGQ 2113

  Fly   738 KHPDFRNFITSILTMIRMILGDFQYNLIEQANRVLGPIYFLTYILLVFFILLNMFLAIIMETYNT 802
            ...::.|.|.|..|:....:..|| |.....||:||.::..:::|::..:|:|:|.|:|:..|..
Human  2114 HEWNYSNLIHSTQTVFSYCVSAFQ-NTEFSNNRILGVLFLSSFMLVMICVLINLFQAVILSAYEE 2177

  Fly   803 VKGEITQGRS---HLGSYIYRKLSGMLYWITHCGRKRRHHPQASETEDKDAEHDVGAAHDETHEI 864
            :|..:.:..|   ...:|:.|||..|..::|            |:::.||
Human  2178 MKQPVYEEPSDEVEAMTYLCRKLRTMFSFLT------------SQSKAKD--------------- 2215

  Fly   865 RKNMTPAEQQYFKDIPQGE 883
                   |.::|.|:..|:
Human  2216 -------EPEFFIDMLYGQ 2227

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkd2	NP_609561.2	PKD_channel	402..803	CDD:285288	92/421 (22%)
PKDREJ	NP_006062.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	154..177
		REJ	243..711	CDD:280229
		GPS	1100..1166	CDD:295363
		PLAT_polycystin	1231..1346	CDD:238850
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1494..1562
		PKD_channel	1748..2178	CDD:285288	120/550 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151826
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740