DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkd2 and pkd2l1

DIOPT Version :9

Sequence 1:	NP_609561.2	Gene:	Pkd2 / 34651	FlyBaseID:	FBgn0041195	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	XP_002936910.2	Gene:	pkd2l1 / 100495064	XenbaseID:	XB-GENE-954499	Length:	832	Species:	Xenopus tropicalis

Alignment Length:	842	Identity:	241/842 - (28%)
Similarity:	374/842 - (44%)	Gaps:	193/842 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 GQSTSDKPSTSDKPSTSDKPSTSARTTVREPGPSSSPSRPVSTRESGRITFQEAAPSTSAKVVKL 168
            |:...|.|:....||...|...:.:|.:..|..:..
Frog    24 GKRAWDNPAFDGSPSLKIKAIYNPKTVLENPYDNLE----------------------------- 59

  Fly   169 AASEPRPAKPPEKEGFSLFKRKKKSVGSSTPPSPSRGHRAPSIIAASALQNRAKTNRILYTTDEE 233
            ...:|    ||.:|.    |:.|::..|.......:|.|.   :..:.|......||.||
Frog    60 QLGDP----PPYQEE----KKHKRNPCSQCCMYIVKGIRG---LWGTTLTENTAENRELY----- 108

  Fly   234 VREALVEFSVFIIFLILTSLVVLSVRHTYMFYFNDTMKKLFTNREMVVAPSVTVGFEKLITVPDW 298
            ::..|.|..|:|:||:...|:...:..|..:|:.:.|.|||.:.:    ....|.|:.:..:.|:
Frog   109 IKTTLRELLVYIVFLVDICLLTYGMTSTNTYYYTNVMSKLFLDTQ----SDSGVTFKAISNMDDF 169

  Fly   299 WDYLKYNFLVTLHGDLTFMDDAQANLTSMPPEGSEQGSEQGSEQGSEQSPEEVVGEAPEEAPEMD 363
            |.||                                                       :.|.:|
Frog   170 WSYL-------------------------------------------------------QGPMLD 179

  Fly   364 RLQEDFKYNGNPYIDLRGHRRAKRQSGVDGNSEDGSEDVSGNYLKDDSDSIQANMSFHHLEGRVF 428
            .|.....||                            :||   |.|:::|:             .
Frog   180 GLYWTKWYN----------------------------NVS---LTDNTNSL-------------I 200

  Fly   429 LYENLLLGPPRLRQIRVRKESCYVNDAFIRYFNTCYAAYSSGAEDRKP--MHKGS--PFRTMHDL 489
            .|||||||.||:||::|:..||.|...|......|:..||...||...  :..|:  .:.|..:|
Frog   201 YYENLLLGVPRMRQLKVKNNSCMVYKDFKDEIVGCFDVYSKDKEDTSQFGLINGTAWTYYTEEEL 265

  Fly   490 DSTPIWTVLAFYRTGGYTVNLDYDKDRNVKIINDLKDIHWLDRGSRLCLVEFNLFNENTDIFQSI 554
            ..:..|..:..|..|||.::|:..|..:::.:..||...|||||:|...|:|:::|.|.::|..:
Frog   266 GGSSYWGKITTYSGGGYYIDLELTKRDSLRQLQTLKSNLWLDRGTRAVFVDFSVYNANINLFCVL 330

  Fly   555 KLIAEIPPTGGVIPQAHLQTVKMYSFFTDRSMLMTVIYIFWYIMVIYYTIYEITEIRKSGIKIYF 619
            :|:.|.|.|||.||...::|||:..:.:.....:....|.:.|.:.||.:.||.|:|....: ||
Frog   331 RLVVEFPATGGAIPSWQIRTVKLIRYVSGWDYFIIGCEIVFCIFIFYYVVEEILELRIHKFR-YF 394

  Fly   620 CSMLNILDCAILLGCYLALVYNIWHSFKVMSLTARAHSDVT-YQSLDVLCFWNIIYVDMMAILAF 683
            .|:.||||..::|...:|:.::|:.:.:|..|......:.| |...:.|.||...|.:|.|:..|
Frog   395 TSIWNILDVIVILLSLVAIGFHIFRTMEVNRLMGTLLKNPTIYADFEFLAFWQTQYNNMNAVNLF 459

  Fly   684 LVWIKIFKFISFNKTLVQFTTTLKRCSKDLAGFSLMFGIVFLAYAQLGLLLFGTKHPDFRNFITS 748
            ..||||||:||||||:.|.::||.||:||:.||::||.|||.||||||.|||||:..:|..|:..
Frog   460 FAWIKIFKYISFNKTMTQLSSTLARCAKDILGFAIMFFIVFFAYAQLGYLLFGTQVENFSTFVKC 524

  Fly   749 ILTMIRMILGDFQYNLIEQANRVLGPIYFLTYILLVFFILLNMFLAIIMETYNTVKGEITQGRSH 813
            |.|..|:|||||.|:.|:.||||||||||:||:..|||:|||||||||.:||:.||.|::..::.
Frog   525 IFTQFRIILGDFDYDAIDNANRVLGPIYFVTYVFFVFFVLLNMFLAIINDTYSEVKEELSNQKNE 589

  Fly   814 LGSYIYRKLSGML---YWITHCGRK-------------RRHHPQASETEDKDAEHDVGAAHDETH 862
            |      :.|.:|   |..|....|             :..:.:....|.|::..::|  ||: |
Frog   590 L------QFSDILKQGYKKTLLKLKLKKERISDVQKALQNGNKELKFEEFKNSLREMG--HDD-H 645

  Fly   863 EIRKNMTPAEQQYFKDIPQGENQDMVRL--NNRVGLLEEI-----------LEKLINNMDDI 911
            ||....:..:|...:.:.:.|...|.::  ..||.|..||           ||:.: |:|||
Frog   646 EISAAFSNFDQDGNRILDEEEQMRMKQILEERRVALNAEIENLGRSYRNKRLEEEV-NLDDI 706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkd2	NP_609561.2	PKD_channel	402..803	CDD:285288	164/405 (40%)
pkd2l1	XP_002936910.2	PKD_channel	160..579	CDD:369653	174/518 (34%)
		SCP-1	<573..809	CDD:114219	33/144 (23%)
		Fer4_24	717..751	CDD:375558
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	305	1.000	Domainoid score	I1364
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	351	1.000	Inparanoid score	I2222
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D205541at33208
OrthoFinder	1	1.000	-	-		FOG0002518
OrthoInspector	1	1.000	-	-		otm47844
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1653
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060