DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkd2 and pkd1

DIOPT Version :9

Sequence 1:	NP_609561.2	Gene:	Pkd2 / 34651	FlyBaseID:	FBgn0041195	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	XP_017952982.2	Gene:	pkd1 / 100494429	XenbaseID:	XB-GENE-483409	Length:	4354	Species:	Xenopus tropicalis

Alignment Length:	531	Identity:	121/531 - (22%)
Similarity:	225/531 - (42%)	Gaps:	80/531 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   434 LLGPPRLRQIRVRK--------------ESC--YVNDAFIR-----YFNTCYAAYSSGAEDRKPM 477
            :||..||||||:::              .||  ..:||..:     ..|..|:         .|.
Frog  3733 MLGVARLRQIRLKEALPTSCSLQLFSAGRSCPELFDDAIFKSATLPSLNWSYS---------PPD 3788

  Fly   478 HKGSPFRTMHDLDSTPIWTVLAFYRTGGYTVNLDYDKDRNVKIINDLKDIHWLDRGSRLCLVEFN 542
            |.|:.:           |..|:||.|.||...|...:..|.:::.:|:..:|:|..:|...|||:
Frog  3789 HTGAWY-----------WGFLSFYDTSGYVQLLQGSQKDNEELLEELQQSYWIDNLTRALFVEFS 3842

  Fly   543 LFNENTDIFQSIKLIAEIPPTGGVIPQAHLQTVKMYSFFTDRSMLMTVIYIFWYIMVIYYTIYEI 607
            |::...:::.|:.|:.|.|..|..:|..:::...:.. .|..:.|:.|:.:|..:.|:|:.:.|.
Frog  3843 LYSPGVELYASVTLLLEFPLAGRALPSVNIRAFPLLR-LTSGTHLLLVMMVFLMMFVVYFVLSEC 3906

  Fly   608 TEIRKSGIKIYFCSMLNILD--------CAILLGCYL---ALVYNIWHSFKVMSLTARAHSDVTY 661
            ..|||.|:: ||....|.:.        |.:::  ||   :|....|..:        ......:
Frog  3907 LIIRKEGLQ-YFTRFWNYVQWLLTVLAVCTVVV--YLSKASLADRQWDRY--------LKDKEAF 3960

  Fly   662 QSLDVLCFWNIIYVDMMAILAFLVWIKIFKFISFNKTLVQFTTTLKRCSKDL-AGFSLMFGIVFL 725
            .||..:.|....:..:.|.:.|::.:|..:.:.|.:....|..||...:::| |....:||:| |
Frog  3961 VSLYQVGFLGNTFHSLSASILFVLTVKAAQQMRFIREWSAFGKTLSLAARELCAASGAVFGLV-L 4024

  Fly   726 AYAQLGLLLFGTKHPDFRNFITSILTMIRMILGDFQYNLIEQANRVLGPIYFLTYILLVFFILLN 790
            .|||||.|||.:....|.:|.:||||:..:..|:.........:..:..:||.:|::|..:|||.
Frog  4025 VYAQLGFLLFSSSWEKFHSFGSSILTLFAVARGNVSLKAPFPYSSTISHLYFASYLVLEVWILLR 4089

  Fly   791 MFLAIIMETYNTVKGEITQGRSHLGSY--IYRKLSGMLYWITHCGRKRRHH----------PQAS 843
            :|.|:::.:|..|:.|:.:.......|  :...|..:..|:.....|...|          |..|
Frog  4090 LFAAVLINSYRQVRLEMFRPAFEPQDYEMVELFLRRLRIWMGVSKVKEFRHKVRFEGMEPLPSRS 4154

  Fly   844 ETEDKDAEHDVGAAHDETHEIRKNMTPAEQQYFKDIPQGENQDMVRLNNRVGLLEEILEKLINNM 908
            .::.|.......:|..:|.......|.:.|  ...:.....::...::..|..|..:|:.|::..
Frog  4155 SSDSKSIRGLTPSAASDTSSSSSFSTISSQ--LDSLSAISARERAEIDANVQRLVPVLDALLSQF 4217

  Fly   909 DDILKRVEKDY 919
            |.:.:..|..|
Frog  4218 DQVNQATEDVY 4228

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkd2	NP_609561.2	PKD_channel	402..803	CDD:285288	100/401 (25%)
pkd1	XP_017952982.2	LRR_8	<83..114	CDD:404697
		leucine-rich repeat	83..103	CDD:275378
		leucine-rich repeat	104..127	CDD:275378
		PCC	108..2722	CDD:188093
		leucine-rich repeat	128..140	CDD:275378
		GPS	2996..3045	CDD:413374
		PLAT_polycystin	3103..3222	CDD:238850
		PKD_channel	3699..4102	CDD:400395	100/401 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000