DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkd2 and pkd1a

DIOPT Version :9

Sequence 1:	NP_609561.2	Gene:	Pkd2 / 34651	FlyBaseID:	FBgn0041195	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	XP_021333081.1	Gene:	pkd1a / 100149562	ZFINID:	ZDB-GENE-100707-1	Length:	4625	Species:	Danio rerio

Alignment Length:	898	Identity:	177/898 - (19%)
Similarity:	298/898 - (33%)	Gaps:	302/898 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 PPPATKRVSIGVGSTRSAPPPATDPT---GP--PP--TAGKPVRDTGPSTSPRP----------S 99
            |.|:||.:..........|...|||:   ||  ||  ..|:..|..|...:..|          |
Zfish  3494 PTPSTKSLQRWSMPDCDWPDVLTDPSVEMGPVFPPRLKRGQGSRHLGVDITFSPDHEDDTVCQNS 3558

  Fly   100 LRDPGQSTSDK--------------PSTSDKPSTS----DKPSTSARTTVREPGPSSSPSRPVST 146
            .|:...|:||:              .:.||....|    ||........:.||.|.:
Zfish  3559 HRNKYFSSSDEDLIKRILADGQLLSQTDSDVGDLSSIFGDKTEVILLQKMNEPVPCA-------- 3615

  Fly   147 RESGRITFQEAAPST--SAKVVKLAASEPRPAKP------------------------------- 178
                  ||:...|.|  :::.|.....:|||..|
Zfish  3616 ------TFRRDPPKTAFTSRTVVADVCKPRPLPPLCGLAALWASWAGLILSSSLSMWLGRGFSEG 3674

  Fly   179 ---------------------PEK---EG--FSLFKRK----KKSVGSSTPPSPSRGHRAPSI-- 211
                                 |.|   ||  |||..|:    ::.|....|.......|.|.:
Zfish  3675 VALMWLISCIVSFLSSFLLLEPLKVLLEGVYFSLVVRRLRPEEQDVLVECPRVERVVQRIPRVRP 3739

  Fly   212 ---IAASALQNRAKTNRILYTTDEEVREALVEFSVFIIFLILTSLVVLSVRHTYMFYFNDTMK-- 271
               .|.|..:..|:..|:|:|       .|..|.::::||    :|||      :..::|:.|
Zfish  3740 PQGFALSQAREEARKVRLLHT-------MLKGFLLYMLFL----MVVL------LLNYSDSEKDA 3787

  Fly   272 -KLFTNREMVVAPSVTVGFEKLITVPDWWDYLKYNFLVTLHGDLTFMDDAQANLTSMPPEGSEQG 335
             :|..|.:: ....:|..|..:.:..|.|.:|..:.|..|      :|
Zfish  3788 HRLRLNAQL-QDHFLTKHFNNISSREDVWAWLSNSLLPRL------LD----------------- 3828

  Fly   336 SEQGSEQGSEQSPEEVVGEAPEEAPEMDRLQEDFKYNGNPYIDLRGHRRAKRQSGVDGNSEDGSE 400
                         |:|:.|                                         :.||
Zfish  3829 -------------EQVLME-----------------------------------------KTGS- 3838

  Fly   401 DVSGNYLKDDSDSIQANMSFHHLEGRVFLYENLLLGPPRLRQIRVRKESCYVNDAF--IRYFNTC 463
                                            ||:|..||||.|.:.| |.|:..|  ..:|...
Zfish  3839 --------------------------------LLIGRARLRQTRAQPE-CPVSGYFPASSWFGCV 3870

  Fly   464 YAAY---SSGAEDRKPMHKGSPFRTMHDLDSTPIWTVLAFYRTGGYTVNLDYDKDRNVKIINDLK 525
            .|.:   :||......:.........|       |..::.|.:.|:..:|......:..:||.|.
Zfish  3871 QAGWAESASGLVQNWSVSTAQSSGVWH-------WGQVSVYSSSGFVQDLSRKMQDSKNLINQLN 3928

  Fly   526 DIHWLDRGSRLCLVEFNLFNENTDIFQSIKLIAEIPPTGGVIPQAHLQ-TVKMYSFFT-----DR 584
            ...|||..:|...:||:|:|.|||:......:.|.|    |..:|.|. .:|.:|..|     |.
Zfish  3929 THQWLDPLTRALFLEFSLYNINTDLLSVFSFLLEFP----VSERAQLSLDLKTFSLHTLSHGMDL 3989

  Fly   585 SMLMTVIYIFWYIMVIYYTIYEITEIRKSGIKIYFCSMLNILD-CAILLGCYLALVY-------- 640
            .:.:|:|.:   :::||:::.|...:.|.| :.||..:.|:.. |::||...:|.::
Zfish  3990 PLFLTLILL---VLLIYFSVREGLLVWKQG-RCYFLRVWNLASVCSLLLAVCVASLHLSRSVVSA 4050

  Fly   641 NIWHSFKVMSLTARAHSDVTYQSLDVLCFWNIIYVDMMAILAFLVWIKIFKFISFNKTLVQFTTT 705
            ..|.:|       ..|.| .:.....|...|.:...|.|.|.||:.:|....:.|.:....|..|
Zfish  4051 QQWRAF-------LQHRD-AFTDFFPLAQQNQLLTQMSATLLFLLVLKASHQLRFLREWGVFGRT 4107

  Fly   706 LKRCSKDLAGFSLMFGIVFLAYAQLGLLLFGTKHPDFRNFITSILTMIRMILGDFQYNLIEQANR 770
            |::...:|...::...:..|||:..|.|||   |.....:.|...|..::|....:..|..:.:.
Zfish  4108 LRKSFWELLMVAVTLLVFLLAYSHTGHLLF---HSVMEGYGTVSSTCFKLIGSSGRGLLSWRPDS 4169

  Fly   771 VLGP------IYFLTYILLVFFILLNMFLAIIMETYNTVKGEITQGRSHLGSY 817
            ...|      |:::::.|| ..:||.:.::.::..|...:.|:.:....|..|
Zfish  4170 GSFPCSGSCFIFYISFTLL-RLVLLWILMSALLRNYRRARAELYRPAVDLQDY 4221

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkd2	NP_609561.2	PKD_channel	402..803	CDD:285288	94/426 (22%)
pkd1a	XP_021333081.1	LRR	<68..>167	CDD:227223
		leucine-rich repeat	88..110	CDD:275378
		leucine-rich repeat	111..133	CDD:275378
		leucine-rich repeat	134..157	CDD:275378
		PCC	138..2795	CDD:188093
		leucine-rich repeat	158..170	CDD:275378
		GPS	3106..3155	CDD:197639
		PLAT	3213..3326	CDD:320707
		PKD_channel	3802..4155	CDD:332708	98/489 (20%)
		Atrophin-1	4496..>4606	CDD:331285
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586380
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3599
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740