DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pkd2 and pkd2

DIOPT Version :9

Sequence 1:	NP_609561.2	Gene:	Pkd2 / 34651	FlyBaseID:	FBgn0041195	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	XP_002938673.2	Gene:	pkd2 / 100038156	XenbaseID:	XB-GENE-482111	Length:	947	Species:	Xenopus tropicalis

Alignment Length:	852	Identity:	230/852 - (26%)
Similarity:	372/852 - (43%)	Gaps:	185/852 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 DKPSTSDKPSTSDKPSTSARTTVRE----------PGPSSSPSRPVSTR--------ESGRITFQ 155
            :|.:....||...:......|..|:          |.|.||.||...:|        |.|   .:
Frog    28 EKKAAPGAPSLQPQDMVELETITRQEPPAPPGGATPSPLSSCSRQAWSRDNPGFDAEEDG---ME 89

  Fly   156 EAAPSTSAKVVKLAASEPRPAKPPEKEGFSLF-----------------KRKKKSVGSSTPPSPS 203
            |........||::.. |..|:..|.:...||.                 :|.:|..|.....:..
Frog    90 EEEDGEEGMVVEMDV-EWHPSAGPGRRSSSLVSSSSGGSTGLGGYHHHGQRGRKRRGDPGMGAGR 153

  Fly   204 RGH---RAPSIIAASALQNRAK-------TNRILYTTDEEVREALVEFSVFIIFLILTSLVVLSV 258
            .||   :...:..|..|.:|.:       |...:.|.::.::....|...:|:||::..::..|:
Frog   154 NGHSTEQPQELEGAGKLLHRVRGLWGTRYTEERITTREKYLKIVFRELITYIVFLVIVCVLTYSM 218

  Fly   259 RHTYMFYFNDTMKKLFTNREMVVAPSVTVGFEKLITVPDWWDYLKYNFLVTLHGDLTFMDDAQAN 323
            ..:.|||:...|.:||.:..  |:......|:.|:|:.|:|.:
Frog   219 VTSNMFYYTKGMSQLFLDGP--VSKDERTNFKTLLTMDDFWKF---------------------- 259

  Fly   324 LTSMPPEGSEQGSEQGSEQGSEQSPEEVVGEAPEEAPEMDRLQEDFKYNGNPYIDLRGHRRAKRQ 388
                                             .|.|.||.|..|..||..
Frog   260 ---------------------------------TEGPLMDGLYWDMWYNNR-------------- 277

  Fly   389 SGVDGNSEDGSEDVSGNYLKDDSDSIQANMSFHHLEGRVFLYENLLLGPPRLRQIRVRKESCYVN 453
                                    ::..|.||       ..|||||||.|||||:||:..||.|.
Frog   278 ------------------------TMAENHSF-------IYYENLLLGVPRLRQLRVKNGSCSVP 311

  Fly   454 DAFIRYFNTCYAAYSSGAEDRKP--MHKGS--PFRTMHDLDSTPIWTVLAFYRTGGYTVNLDYDK 514
            :........||.:||...||..|  :..|:  .:....||:.:..|.|::.|...||.::|..::
Frog   312 EDLKDEIKDCYDSYSVRNEDTTPFGLRNGTAWTYTKEKDLNGSSQWGVISVYSGAGYYIDLSRNR 376

  Fly   515 DRNVKIINDLKDIHWLDRGSRLCLVEFNLFNENTDIFQSIKLIAEIPPTGGVIPQAHLQTVKMYS 579
            :.:...|..||:..|||||:|...::|:::|.|.::|..::|:.|.|.|||:|.....||||:..
Frog   377 EESAAQIAMLKNNLWLDRGTRAVFIDFSVYNANLNLFCVVRLLVEFPATGGLITSWQFQTVKLIH 441

  Fly   580 FFTDRSMLMTVIYIFWYIMVIYYTIYEITEIRKSGIKIYFCSMLNILDCAILLGCYLALVYNIWH 644
            :.:.....:....|.:.|.::||.|.|..||....:. ||.|:.|.|| .:::|..|..: .| |
Frog   442 YISSFEFFLAACEIIFCIFILYYIIEEFLEIHVHHLH-YFRSLWNWLD-IVIIGLSLPAI-GI-H 502

  Fly   645 SFKVMSLTARAHSDVT----YQSLDVLCFWNIIYVDMMAILAFLVWIKIFKFISFNKTLVQFTTT 705
            .:|:.|:....:..::    :.:|:.|.:|.|.:..:.|::.|..|:|:|||.:||:|:.|.:||
Frog   503 LYKMSSVEGPLNKQLSDLNVFPNLESLAYWQIQFNSVAAVIVFFAWVKLFKFANFNRTMTQLSTT 567

  Fly   706 LKRCSKDLAGFSLMFGIVFLAYAQLGLLLFGTKHPDFRNFITSILTMIRMILGDFQYNLIEQANR 770
            :.||:||:.||::||.|:||||||...|:|||:..||..|...|.|..|:|||||.:..:|:|||
Frog   568 MSRCAKDILGFAIMFFIIFLAYAQFAYLVFGTQIDDFSTFQHCIFTQFRIILGDFDFTEVEEANR 632

  Fly   771 VLGPIYFLTYILLVFFILLNMFLAIIMETYNTVKGEITQGRSHL-----------GSYIYRKL-- 822
            :||||||.|::..:||||||||||||.:||:.||.::.|.:|.:           .:.:..||
Frog   633 ILGPIYFTTFVFFMFFILLNMFLAIINDTYSEVKTDMAQQKSEMELIDLIKKGCSKAMVKLKLKK 697

  Fly   823 ---SGMLYWITHCGRKRRHHPQASETEDK---DAEHD-VGAAHDETHEIRKNMTPAEQQYFKDIP 880
               ..:...|...|.|........:.:.|   |||.: :.|.:|:..:  :.:|..|.|..:|..
Frog   698 TTVDDISESIRQGGGKLNFDELRQDLKGKGHTDAEIEAIFAKYDQDGD--QELTENEHQQMRDDL 760

  Fly   881 QGENQDM 887
            :.|.:|:
Frog   761 EKEREDL 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pkd2	NP_609561.2	PKD_channel	402..803	CDD:285288	152/408 (37%)
pkd2	XP_002938673.2	PKD_channel	245..665	CDD:369653	165/523 (32%)
		EFh	710..756	CDD:238008	11/47 (23%)
		Fer4_24	815..846	CDD:375558
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	305	1.000	Domainoid score	I1364
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	351	1.000	Inparanoid score	I2222
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D205541at33208
OrthoFinder	1	1.000	-	-		FOG0002518
OrthoInspector	1	1.000	-	-		otm47844
Panther	1	1.100	-	-	O	PTHR10877
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1653
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160