DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bru1 and FCA

DIOPT Version :9

Sequence 1:	NP_001260403.1	Gene:	bru1 / 34648	FlyBaseID:	FBgn0000114	Length:	810	Species:	Drosophila melanogaster
Sequence 2:	NP_001319956.1	Gene:	FCA / 827323	AraportID:	AT4G16280	Length:	747	Species:	Arabidopsis thaliana

Alignment Length:	541	Identity:	146/541 - (26%)
Similarity:	227/541 - (41%)	Gaps:	127/541 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   357 IKMFVGQVPKSMDESQLREMFEEYGAVHSINVLRDKATGISKGCCFVTFYTRHAALKAQDALHNV 421
            :|:|||.||::..|.::|..||::|.|..:.:::||.||..:|||||.:.|...|.:|..||||.
plant   120 VKLFVGSVPRTATEEEIRPYFEQHGNVLEVALIKDKRTGQQQGCCFVKYATSKDADRAIRALHNQ 184

  Fly   422 KTLNGMYHPIQMKPADSENRN----ERKLFVGMLNKKLNENDVRKLFEVHGAIEECTVLRDQNGQ 482
            .||.|...|:|::.||.|...    |.|||||.|||:..|.:|.::|...|.:|:..::||:..|
plant   185 ITLPGGTGPVQVRYADGERERIGTLEFKLFVGSLNKQATEKEVEEIFLQFGHVEDVYLMRDEYRQ 249

  Fly   483 SKGCAFVTFATKHAAISAIKVTLSQNKIMEGCTSPLVVKFADTQKEK--EQKKI---------QQ 536
            |:||.||.:::|..|::||. .|:....|.||..||:|:||:.::.|  |.:::         .:
plant   250 SRGCGFVKYSSKETAMAAID-GLNGTYTMRGCNQPLIVRFAEPKRPKPGESREMAPPVGLGSGPR 313

  Fly   537 IQA-------------------NLWNLASNINI-PLGQT----ATSVTTP-----ILPN------ 566
            .||                   |.|..|::.|: |...|    |.|..:|     .||:
plant   314 FQASGPRPTSNFGDSSGDVSHTNPWRPATSRNVGPPSNTGIRGAGSDFSPKPGQATLPSNQGGPL 378

  Fly   567 -----PPQQPSPVLGADAITPASIQLLQQLQAVGLQH-----QLLQALTGL-----------GAQ 610
                 ||..|.||.|..    :|..|.||.:|.| ||     :.|.:..||           |||
plant   379 GGYGVPPLNPLPVPGVS----SSATLQQQNRAAG-QHITPLKKPLHSPQGLPLPLRPQTNFPGAQ 438

  Fly   611 QS-------SSATDTSAVAAAGLLTPMTVQNLAAIAAMTQP---SLSNAAAAAAAATSPGSAQL- 664
            ..       ||...||.      |.|.  ||::...|...|   :|.....::|....|..:|.
plant   439 APLQNPYAYSSQLPTSQ------LPPQ--QNISRATAPQTPLNINLRPTTVSSATVQFPPRSQQQ 495

  Fly   665 ---------TNTAALLWSDPNPMASAYMSTAAGLPQFGSASALSTSPLASVALSAAAAAAAGKQI 720
                     :..|.||......:.:.:.|:...:.|..........|..::.||  ....||||.
plant   496 PLQKMQHPPSELAQLLSQQTQSLQATFQSSQQAISQLQQQVQSMQQPNQNLPLS--QNGRAGKQQ 558

  Fly   721 EGPEGCNLFIYHLPQEFTDTDLASTFLPFGNVISAKVFIDKQTSLSKCFGFVSFDNPDSAQVAIK 785
            .....       :|:..:.|  .||  |...|.:|...:.:.....|| .:....:||..:....
plant   559 WAGSA-------IPRVASTT--GST--PVSYVQTAAPAVSQSVGSVKC-TWTEHTSPDGFKYYYN 611

  Fly   786 AMNGFQVGTKRLKVQLKKPKD 806
            .:.|        :.:.:||::
plant   612 GLTG--------ESKWEKPEE 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bru1	NP_001260403.1	RRM1_CELF1_2_Bruno	356..437	CDD:241075	33/79 (42%)
		ELAV_HUD_SF	359..808	CDD:273741	145/539 (27%)
		RRM2_Bruno_like	443..524	CDD:241080	34/80 (43%)
		RRM3_Bruno_like	722..800	CDD:241084	12/77 (16%)
FCA	NP_001319956.1	LSM_int_assoc	<121..497	CDD:330438	120/389 (31%)
		RRM1_FCA	121..200	CDD:241077	33/78 (42%)
		RRM2_FCA	212..291	CDD:241081	34/79 (43%)
		WW	597..624	CDD:238122	5/34 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	62	1.000	Domainoid score	I3741
eggNOG	1	0.900	-	-		E1_KOG0144
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1209165at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24012
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920