DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bru1 and Celf3

DIOPT Version :9

Sequence 1:	NP_001260403.1	Gene:	bru1 / 34648	FlyBaseID:	FBgn0000114	Length:	810	Species:	Drosophila melanogaster
Sequence 2:	NP_001276542.1	Gene:	Celf3 / 78784	MGIID:	1926034	Length:	494	Species:	Mus musculus

Alignment Length:	514	Identity:	219/514 - (42%)
Similarity:	296/514 - (57%)	Gaps:	78/514 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   353 DPDNIKMFVGQVPKSMDESQLREMFEEYGAVHSINVLRDKATGISKGCCFVTFYTRHAALKAQDA 417
            :||.||:||||:|:.::|..|:.:||::|.:..:.|::||.||:.|||.|:|:..|.:|||||.|
Mouse     3 EPDAIKLFVGQIPRHLEEKDLKPIFEQFGRIFELTVIKDKYTGLHKGCAFLTYCARDSALKAQSA 67

  Fly   418 LHNVKTLNGMYHPIQMKPADSENRNE-RKLFVGMLNKKLNENDVRKLFEVHGAIEECTVLRDQNG 481
            ||..|||.||..|||:||||||:|.| ||||||||.|:..:.||||:||..|.|:||||||..:|
Mouse    68 LHEQKTLPGMNRPIQVKPADSESRGEDRKLFVGMLGKQQTDEDVRKMFEPFGTIDECTVLRGPDG 132

  Fly   482 QSKGCAFVTFATKHAAISAIKVTLSQNKIMEGCTSPLVVKFADTQKEKEQKKIQQIQANLWNLAS 546
            .|||||||.|.| ||...|...||..::.:.|.:|.||||||||:||:..:::||:...| .:.|
Mouse   133 TSKGCAFVKFQT-HAEAQAAINTLHSSRTLPGASSSLVVKFADTEKERGLRRMQQVATQL-GMFS 195

  Fly   547 NINIPLGQTATSVTTPILPNPPQQPSPVLGADAITPASIQLLQQLQAVGLQHQLLQALTGLGAQ- 610
            .|.:..|  |.|..|..|   .||.:.::.|.:   |.:..:..:.||.:||....:..||.|.
Mouse   196 PIALQFG--AYSAYTQAL---MQQQAALVAAHS---AYLSPMATMAAVQMQHMAAISANGLIATP 252

  Fly   611 -QSSSATDTSAVAAAGLLTPMTVQNLAAIAAM---------TQPSLSNAA-------------AA 652
             ..||.|.|....||   ||::    |..||:         |||:...|.             .|
Mouse   253 ITPSSGTSTPPAIAA---TPVS----AIPAALGVNGYSPVPTQPTGQPAPDALYPNGVHPYPDEA 310

  Fly   653 AAAATSPGSAQLTNTAALLW-----------SDPNPMASAYMSTAAGLPQFGSASALSTSPLASV 706
            .:|..|.|...:.:.|. .|           :..:|:..||    ||:..:.:|...:.|.:|..
Mouse   311 LSAERSAGGVPIMSQAH-SWLVMLSAAQSPAAPVDPLQQAY----AGMQHYTAAYPAAYSLVAPA 370

  Fly   707 ALSAAAAAA-------------------AGKQIEGPEGCNLFIYHLPQEFTDTDLASTFLPFGNV 752
            .....|..|                   ..:|.|||:|||:|||||||||||:::...|:|||:|
Mouse   371 FPQPPALVAQQPPPPPQQQQQQQQQQQQQQQQREGPDGCNIFIYHLPQEFTDSEILQMFVPFGHV 435

  Fly   753 ISAKVFIDKQTSLSKCFGFVSFDNPDSAQVAIKAMNGFQVGTKRLKVQLKKPKD-SKPY 810
            ||||||:|:.|:.||||||||||||.|||.||:||||||:|.||||||||:||| ::||
Mouse   436 ISAKVFVDRATNQSKCFGFVSFDNPASAQAAIQAMNGFQIGMKRLKVQLKRPKDANRPY 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bru1	NP_001260403.1	RRM1_CELF1_2_Bruno	356..437	CDD:241075	41/80 (51%)
		ELAV_HUD_SF	359..808	CDD:273741	213/504 (42%)
		RRM2_Bruno_like	443..524	CDD:241080	46/81 (57%)
		RRM3_Bruno_like	722..800	CDD:241084	57/77 (74%)
Celf3	NP_001276542.1	RRM1_CELF3_4_5_6	2..88	CDD:410041	44/84 (52%)
		RRM2_CELF3_4_5_6	94..174	CDD:410043	45/80 (56%)
		PRK12323	<214..379	CDD:237057	40/179 (22%)
		RRM3_CELF3_4_5_6	405..483	CDD:241083	57/77 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836403
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0144
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1209165at2759
OrthoFinder	1	1.000	-	-		FOG0000286
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X208
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750