Protein Alignment bru1 and CELF6

DIOPT Version :10

• Sequence 1: NP_723737.1
• Gene: bru1 / 34648
• FlyBaseID: FBgn0000114
• Length: 810
• Species: Drosophila melanogaster
• Sequence 2: NP_443072.3
• Gene: CELF6 / 60677
• HGNCID: 14059
• Length: 481
• Species: Homo sapiens
• Alignment Length: 534
• Identity: 230/534 - (43%)
• Similarity: 302/534 - (56%)
• Gaps: 80/534 - (14%)

  Fly   289 PSLGGSNSNALVSVGSNGIMSAAGLVNNNNNPCSANRNVVAMVDDDACFRLDTDATVTYGEKEPD 353
            |.||.|.:::  .||.:|:           ||..|    |.|.|.||
Human    16 PRLGFSTADS--GVGMSGL-----------NPGPA----VPMKDHDA------------------ 45

  Fly   354 PDNIKMFVGQVPKSMDESQLREMFEEYGAVHSINVLRDKATGISKGCCFVTFYTRHAALKAQDAL 418
               ||:||||:|:.:||..|:.:|||:|.::.:.||:|:.||:.|||.|:|:..|.:|||||.||
Human    46 ---IKLFVGQIPRGLDEQDLKPLFEEFGRIYELTVLKDRLTGLHKGCAFLTYCARDSALKAQSAL 107

  Fly   419 HNVKTLNGMYHPIQMKPADSENRNE-RKLFVGMLNKKLNENDVRKLFEVHGAIEECTVLRDQNGQ 482
            |..|||.||..|||:|||.||.|.| ||||||||.|:..|.|||:||:..|.||||||||..:|.
Human   108 HEQKTLPGMNRPIQVKPAASEGRGEDRKLFVGMLGKQQGEEDVRRLFQPFGHIEECTVLRSPDGT 172

  Fly   483 SKGCAFVTFATKHAAISAIKVTLSQNKIMEGCTSPLVVKFADTQKEKEQKKIQQIQANLWNLASN 547
            |||||||.|.::..|.:||: .|..::.|.|.:|.||||.|||.:|:..:::||:..:| .....
Human   173 SKGCAFVKFGSQGEAQAAIR-GLHGSRTMAGASSSLVVKLADTDRERALRRMQQMAGHL-GAFHP 235

  Fly   548 INIPLGQTATSVTTPILPNPPQQPSPVLGADAITPASIQLLQQLQAVGLQHQLLQALTGLGAQQS 612
            ..:||| ...:.||.||     |....|.|.|..|.    |..:.||..|.|.:.|.:.:.|...
Human   236 APLPLG-ACGAYTTAIL-----QHQAALLAAAQGPG----LGPVAAVAAQMQHVAAFSLVAAPLL 290

  Fly   613 SSATDTSAVAAA-----GLLTPMTVQNLAAIAAMT--QP---SLSNAAAAAAAATSPGSAQLTNT 667
            .:|...|...:.     ||..|:.|.....:...|  ||   :|.|...:...|.|||.|
Human   291 PAAAANSPPGSGPGTLPGLPAPIGVNGFGPLTPQTNGQPGSDTLYNNGLSPYPAQSPGVA----- 350

  Fly   668 AALLWSDPNPMASAYMSTAAGLPQFGSASALSTSPLASVALSAAAAAAAGKQIEGPEGCNLFIYH 732
                    :|:..||    ||:..:.:|...:.:|: |.|.....:|...:|.||||||||||||
Human   351 --------DPLQQAY----AGMHHYAAAYPSAYAPV-STAFPQQPSALPQQQREGPEGCNLFIYH 402

  Fly   733 LPQEFTDTDLASTFLPFGNVISAKVFIDKQTSLSKCFGFVSFDNPDSAQVAIKAMNGFQVGTKRL 797
            |||||.|.:|..||||||.|:|||||:|:.|:.||||||||||||.|||.||:||||||:|.|||
Human   403 LPQEFGDAELIQTFLPFGAVVSAKVFVDRATNQSKCFGFVSFDNPTSAQTAIQAMNGFQIGMKRL 467

  Fly   798 KVQLKKPKD-SKPY 810
            |||||:||| ::||
Human   468 KVQLKRPKDANRPY 481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bru1	NP_723737.1	RRM1_CELF1_2_Bruno	356..437	CDD:410040	43/80 (54%)
		SF-CC1	<435..789	CDD:273721	155/364 (43%)
		RRM_SF	443..524	CDD:473069	45/81 (56%)
		RRM3_Bruno_like	722..800	CDD:241084	60/77 (78%)
CELF6	NP_443072.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..34		7/30 (23%)
		RRM1_CELF3_4_5_6	41..127	CDD:410041	47/106 (44%)
		PABP-1234	<48..390	CDD:130689	142/371 (38%)
		RRM2_CELF3_4_5_6	133..213	CDD:410043	44/80 (55%)
		RRM3_CELF3_4_5_6	392..470	CDD:241083	60/77 (78%)