DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bru1 and CELF4

DIOPT Version :9

Sequence 1:	NP_001260403.1	Gene:	bru1 / 34648	FlyBaseID:	FBgn0000114	Length:	810	Species:	Drosophila melanogaster
Sequence 2:	NP_001340669.1	Gene:	CELF4 / 56853	HGNCID:	14015	Length:	545	Species:	Homo sapiens

Alignment Length:	586	Identity:	197/586 - (33%)
Similarity:	270/586 - (46%)	Gaps:	168/586 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   271 SNGTSSNNSLNVGNNNSNPSLGGSNSNALVSVGSNGIMSAAGLVNNNNNPCSANRNVVAMVDDDA 335
            :||.:.|.||:.....|:|             ||.|.|:  ||.::..||     :.:.|.|.||
Human     9 ANGQADNASLSTNGLGSSP-------------GSAGHMN--GLSHSPGNP-----STIPMKDHDA 53

  Fly   336 CFRLDTDATVTYGEKEPDPDNIKMFVGQVPKSMDESQLREMFEEYGAVHSINVLRDKATGISKGC 400
                                 ||:|:||:|:::||..|:.:|||:|.::.:.||:|:.||:.|||
Human    54 ---------------------IKLFIGQIPRNLDEKDLKPLFEEFGKIYELTVLKDRFTGMHKGC 97

  Fly   401 CFVTFYTRHAALKAQDALHNVKTLNGMYHPIQMKPADSENR-----------NERKLFVGMLNKK 454
            .|:|:..|.:|||||.|||..|||.||..|||:||||||:|           .:||||||||||:
Human    98 AFLTYCERESALKAQSALHEQKTLPGMNRPIQVKPADSESRGGSSCLRQPPSQDRKLFVGMLNKQ 162

  Fly   455 LNENDVRKLFEVHGAIEECTVLRDQNGQSKGCAFVTFATKHAAISAIKVTLSQNKIMEGCTSPLV 519
            .:|:|||:|||..|.|||||:||..:|.|||||||.::: ||...|....|..::.|.|.:|.||
Human   163 QSEDDVRRLFEAFGNIEECTILRGPDGNSKGCAFVKYSS-HAEAQAAINALHGSQTMPGASSSLV 226

  Fly   520 VKFADTQKEKEQKKIQQIQANLWNLASNINIPLGQTATSVTTPILPNPPQQPSPVLGADAITPAS 584
            ||||||.||:..:::||:              .||..       :.||...|....||.|
Human   227 VKFADTDKERTMRRMQQM--------------AGQMG-------MFNPMAIPFGAYGAYA----- 265

  Fly   585 IQLLQQLQAVGLQHQLLQALTGLGAQQSSSATDTSAVAAAGLLTPMTVQNLAAIAAMTQPSLSNA 649
             |.|.|.||..:                      ::||..|.|.||.....|.:..|...:::..
Human   266 -QALMQQQAALM----------------------ASVAQGGYLNPMAAFAAAQMQQMAALNMNGL 307

  Fly   650 AAAAAAATSPGSAQLTNTAALLWSDPNPMA---------------SAYMSTAAGLPQFGSASALS 699
            |||....||.||.....||..:.|.|:|:.               :|....|.|:..:.:.|..:
Human   308 AAAPMTPTSGGSTPPGITAPAVPSIPSPIGVNGFTGLPPQANGQPAAEAVFANGIHPYPAQSPTA 372

  Fly   700 TSPLASV-------ALSAAAAAAAG---------------KQIEGPEGCNLFIYHLPQEFTDTDL 742
            ..||...       |..||..||.|               :|.|||||||||||||||||.|.:|
Human   373 ADPLQQAYAGVQQYAGPAAYPAAYGQISQAFPQPPPMIPQQQREGPEGCNLFIYHLPQEFGDAEL 437

  Fly   743 ASTFLPFGNVISAKVFIDKQTSLSKCFGFVSFDNPDSAQVAIKAMNGFQV----GTKRLKVQLKK 803
            ...|||||.                        :|..|:....:..|.|.    .|:||: :|::
Human   438 MQMFLPFGR------------------------HPVPARCQAPSCQGGQCPINSSTRRLR-ELRQ 477

  Fly   804 P 804
            |
Human   478 P 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bru1	NP_001260403.1	RRM1_CELF1_2_Bruno	356..437	CDD:241075	42/80 (53%)
		ELAV_HUD_SF	359..808	CDD:273741	176/498 (35%)
		RRM2_Bruno_like	443..524	CDD:241080	45/80 (56%)
		RRM3_Bruno_like	722..800	CDD:241084	30/81 (37%)
CELF4	NP_001340669.1	Sufficient for RNA-binding and MSE-dependent splicing activity	1..298		138/379 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..39		9/35 (26%)
		RRM1_CELF3_4_5_6	49..135	CDD:241076	46/106 (43%)
		PABP-1234	<56..378	CDD:130689	136/371 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..149		13/27 (48%)
		RRM2_CELF3_4_5_6	151..231	CDD:241079	45/80 (56%)
		Necessary for TNNT2 exon 5 inclusion	239..258		6/39 (15%)
		RRM_SF	417..>445	CDD:388407	21/27 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146322
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0144
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1209165at2759
OrthoFinder	1	1.000	-	-		FOG0000286
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X208
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750