DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bru1 and celf5a

DIOPT Version :9

Sequence 1:	NP_001260403.1	Gene:	bru1 / 34648	FlyBaseID:	FBgn0000114	Length:	810	Species:	Drosophila melanogaster
Sequence 2:	XP_021325030.1	Gene:	celf5a / 568052	ZFINID:	ZDB-GENE-050208-746	Length:	552	Species:	Danio rerio

Alignment Length:	521	Identity:	216/521 - (41%)
Similarity:	284/521 - (54%)	Gaps:	105/521 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   353 DPDNIKMFVGQVPKSMDESQLREMFEEYGAVHSINVLRDKATGISKGCCFVTFYTRHAALKAQDA 417
            |.|.||:|:||:|::::|..|:.:||::|.:|.:.||:|:.||:.|||.|:|:..|.:|:|||:|
Zfish    74 DQDAIKLFIGQIPRNLEEKDLKPLFEQFGKIHELTVLKDRYTGMHKGCAFLTYCARESAIKAQNA 138

  Fly   418 LHNVKTLNGMYHPIQMKPADSENRNE-RKLFVGMLNKKLNENDVRKLFEVHGAIEECTVLRDQNG 481
            ||..|||.||..|||:||||||:|.| ||||||||||:..|.||.:|||.:|.||||||||..:|
Zfish   139 LHEQKTLPGMTRPIQVKPADSESRGEDRKLFVGMLNKQQTEEDVYRLFEPYGVIEECTVLRGPDG 203

  Fly   482 QSKGCAFVTFATKHAAISAIKV--------TLSQNKIMEGCTSPLVVKFADTQKEKEQKKIQQI- 537
            .|||||||.|:|...|.|||..        |.|.:.:.:|.:|.||||||||.||:..:::||:
Zfish   204 NSKGCAFVKFSTHAEAQSAISALHGSQTMPTGSDSLLPQGASSSLVVKFADTDKERTIRRMQQMV 268

  Fly   538 -QANLWNLASNINIPL-----------------------GQTATSVTTP-----------ILPNP 567
             |..::|.|  |.:|.                       |..|.||..|           |...|
Zfish   269 GQFGIFNPA--IALPFSTYSTYAHALMQQQAALMAASHGGYLAPSVAFPTTQIHQMGALNINSLP 331

  Fly   568 PQQPSPVLGADAITPASIQLLQQLQAVGLQHQLLQALTGLGAQQSSSATDTSAVAAAGLLTPMTV 632
            |...:||.|                      :..|.|.||    ||...:.:..|...::||: |
Zfish   332 PTPMTPVSG----------------------EFHQTLAGL----SSPPANITTSAVPSIVTPI-V 369

  Fly   633 QNLAAIAAMTQPSLSNAAAAAAAATSPGSAQLTNTAALLWSDPNPMASAYMSTA-AGLPQFGSAS 696
            ....:|     |...|...|..|..:.|...        :|..:|.|:..:..| .|:.|:...|
Zfish   370 NGFTSI-----PHQPNGHPAVEAVYTNGLPP--------YSTQSPTAADTLQQAFTGVQQYTDLS 421

  Fly   697 ALSTSPLASVAL-SAAAAAAAGKQI---------------EGPEGCNLFIYHLPQEFTDTDLAST 745
            .:...||....: .|......|:.:               |||||||||||||||||.|.:|...
Zfish   422 DIREHPLYLYTIYPATTLTPIGQSLPQPPQVIQQQQQREGEGPEGCNLFIYHLPQEFGDNELMQM 486

  Fly   746 FLPFGNVISAKVFIDKQTSLSKCFGFVSFDNPDSAQVAIKAMNGFQVGTKRLKVQLKKPKD-SKP 809
            |||||.|||:|||:|:.|:.||||||||||||.|||.||:||||||:|.||||||||:||| |:|
Zfish   487 FLPFGTVISSKVFMDRATNQSKCFGFVSFDNPASAQAAIQAMNGFQIGMKRLKVQLKRPKDASRP 551

  Fly   810 Y 810
            |
Zfish   552 Y 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bru1	NP_001260403.1	RRM1_CELF1_2_Bruno	356..437	CDD:241075	40/80 (50%)
		ELAV_HUD_SF	359..808	CDD:273741	209/511 (41%)
		RRM2_Bruno_like	443..524	CDD:241080	49/89 (55%)
		RRM3_Bruno_like	722..800	CDD:241084	59/77 (77%)
celf5a	XP_021325030.1	RRM1_CELF3_4_5_6	73..159	CDD:241076	43/84 (51%)
		RRM	<80..436	CDD:330708	140/397 (35%)
		RRM2_CELF3_4_5_6	165..254	CDD:241079	48/88 (55%)
		RRM3_CELF3_4_5_6	463..541	CDD:241083	59/77 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0144
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1209165at2759
OrthoFinder	1	1.000	-	-		FOG0000286
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X208
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820