DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bru1 and Sxl

DIOPT Version :9

Sequence 1:	NP_001260403.1	Gene:	bru1 / 34648	FlyBaseID:	FBgn0000114	Length:	810	Species:	Drosophila melanogaster
Sequence 2:	NP_001259303.1	Gene:	Sxl / 3772180	FlyBaseID:	FBgn0264270	Length:	722	Species:	Drosophila melanogaster

Alignment Length:	502	Identity:	111/502 - (22%)
Similarity:	184/502 - (36%)	Gaps:	125/502 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   258 NNNPSLLNNN--------NNNSNG----------------------TSSNNSLN--------VGN 284
            ||||...|||        ||.|:|                      :||....|        .||
  Fly     4 NNNPGSNNNNGGYPPYGYNNKSSGGRGFGMSHSLPSGMDTEFSFPSSSSRRGYNDFPGCGGSGGN 68

  Fly   285 NNSNPSLGGSNSNALVSVGSNGIMSAAGLVNNNNNPCSANRNVVAMVDDDACFRLDTDATVTYGE 349
            ..|..:|||.|...|..:.||         |:.||.|..  ::.:...||..
  Fly    69 GGSANNLGGGNMCHLPPMASN---------NSLNNLCGL--SLGSGGSDDLM------------- 109

  Fly   350 KEPDPDNIKMFVGQVPKSMDESQLREMFEEYGAVHSINVLRDKATGISKGCCFVTFYTRHAALKA 414
            .:|...|..:.|..:|:.|.:.:|..:|...|.:::..::||..||.|.|..||.|.:...:.:|
  Fly   110 NDPRASNTNLIVNYLPQDMTDRELYALFRAIGPINTCRIMRDYKTGYSFGYAFVDFTSEMDSQRA 174

  Fly   415 QDALHNVKTLNGMYHPIQMKPADSENRNERKLFVGMLNKKLNENDVRKLFEVHGAIEECTVLRDQ 479
            ...|:.:...|........:|. .|:..:..|:|..|.:.:.::.:..:|..:|:|.:..:|||:
  Fly   175 IKVLNGITVRNKRLKVSYARPG-GESIKDTNLYVTNLPRTITDDQLDTIFGKYGSIVQKNILRDK 238

  Fly   480 -NGQSKGCAFVTFATKHAAISAIKVTLSQNKIMEGCTSPLVVKFADTQKEKEQKKIQQIQANLWN 543
             .|:.:|.|||.:..:..|..||...  .|.|.||.:.||.|:.|:   |..:.|.....:.:..
  Fly   239 LTGRPRGVAFVRYNKREEAQEAISAL--NNVIPEGGSQPLSVRLAE---EHGKAKAAHFMSQMGV 298

  Fly   544 LASNINIPLGQTATSVTTPILPNPPQQPSPVLGADAITPASIQLLQQLQAV----GLQHQLLQAL 604
            :.:|:                |.||.||      .|...|:..::.:..|:    .|...:..|:
  Fly   299 VPANV----------------PPPPPQP------PAHMAAAFNMMHRDGAMEKLRSLFDAICDAI 341

  Fly   605 TGLGAQQSSSATDTSAVAAAGL-----------LTPMTVQNLAAIAAMTQPSLSNAAAAAAAATS 658
            .||.::..:...|       ||           |||...|.|      .|.........:::..|
  Fly   342 FGLDSENFADLLD-------GLYRRKYHYPYLXLTPQQQQQL------LQHQQQALGFTSSSNNS 393

  Fly   659 PGSAQLTNTAALLWSDPNPMASAYMSTAAGLPQFGSASALSTSPLAS 705
            .|:....:...||:.      ..|........:.|:.:|.:.||..|
  Fly   394 IGNGNGNDNNMLLYH------QQYHQQQTQQQRLGNVAAHNISPNGS 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bru1	NP_001260403.1	RRM1_CELF1_2_Bruno	356..437	CDD:241075	20/80 (25%)
		ELAV_HUD_SF	359..808	CDD:273741	79/363 (22%)
		RRM2_Bruno_like	443..524	CDD:241080	24/81 (30%)
		RRM3_Bruno_like	722..800	CDD:241084
Sxl	NP_001259303.1	RRM1_SXL	117..197	CDD:241093	19/80 (24%)
Sxl	NP_001259303.1	RRM2_Hu_like	203..281	CDD:240822	24/79 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24012
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010