DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bru1 and Spx

DIOPT Version :9

Sequence 1:	NP_001260403.1	Gene:	bru1 / 34648	FlyBaseID:	FBgn0000114	Length:	810	Species:	Drosophila melanogaster
Sequence 2:	NP_511058.1	Gene:	Spx / 31558	FlyBaseID:	FBgn0015818	Length:	347	Species:	Drosophila melanogaster

Alignment Length:	260	Identity:	61/260 - (23%)
Similarity:	119/260 - (45%)	Gaps:	47/260 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   342 DATVTYGEKEPDPDNIKMFVGQVPKSMDESQLREMFEEYGAVHSINVLRDKATGISKGCCFVTFY 406
            |||:              :.|.:...:.|:.|.|:|.:.|.|.::::.:|:.|.:.:|..||.|
  Fly    12 DATI--------------YAGGLDDKVSETLLWELFVQAGPVVNVHMPKDRVTQMHQGYGFVEF- 61

  Fly   407 TRHAALKAQDALHNVKTLN--GMY-HPIQMKPADSENRN---ERKLFVGMLNKKLNENDVRKLFE 465
                 |..:||.:.:|.:|  .:| .||::..|.:..:|   ...:|:|.|:.:::|..:...|.
  Fly    62 -----LSEEDADYGIKIMNMIKLYGKPIRVNKASAHQKNLDVGANIFIGNLDVEVDEKLLYDTFS 121

  Fly   466 VHGAI-EECTVLRD-QNGQSKGCAFVTFATKHAAISAIKVTLSQNKIMEG---CTSPLVVKFA-- 523
            ..|.| :...::|| :.|:||..||:.||:..|:.:|:..       |.|   |..|:.|.:|
  Fly   122 AFGVILQTPKIMRDPETGKSKSFAFINFASFEASDAAMDA-------MNGQYLCNRPISVSYAFK 179

  Fly   524 -DTQKEKEQKKIQQIQANLWNLASNINIPLGQTATSVTTPILPN-----PPQQPSPVLGADAITP 582
             |.:.|:.....:::.| ..|.:::.:.|....|.:....::|.     |.|.|..::....:.|
  Fly   180 KDHKGERHGSAAERLLA-AQNPSTHADRPHQLFADAPVQTMMPQMPGQIPAQMPGQMMPPPMMAP 243

Fly 583 582
Fly 244 243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bru1	NP_001260403.1	RRM1_CELF1_2_Bruno	356..437	CDD:241075	21/83 (25%)
		ELAV_HUD_SF	359..808	CDD:273741	58/243 (24%)
		RRM2_Bruno_like	443..524	CDD:241080	24/88 (27%)
		RRM3_Bruno_like	722..800	CDD:241084
Spx	NP_511058.1	RRM1_SF3B4	15..88	CDD:240780	21/92 (23%)
Spx	NP_511058.1	RRM2_SF3B4	99..181	CDD:240781	24/88 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24012
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010