DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bru1 and Celf4

DIOPT Version :9

Sequence 1:	NP_001260403.1	Gene:	bru1 / 34648	FlyBaseID:	FBgn0000114	Length:	810	Species:	Drosophila melanogaster
Sequence 2:	XP_038952808.1	Gene:	Celf4 / 307540	RGDID:	1307630	Length:	583	Species:	Rattus norvegicus

Alignment Length:	548	Identity:	201/548 - (36%)
Similarity:	270/548 - (49%)	Gaps:	139/548 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   271 SNGTSSNNSLNVGNNNSNPSLGGSNSNALVSVGSNGIMSAAGLVNNNNNPCSANRNVVAMVDDDA 335
            :||.:.|.||:.....|:|             ||.|.|:  ||.::..||     :.:.|.|.||
  Rat     9 ANGQADNASLSTNGLGSSP-------------GSAGHMN--GLSHSPGNP-----STIPMKDHDA 53

  Fly   336 CFRLDTDATVTYGEKEPDPDNIKMFVGQVPKSMDESQLREMFEEYGAVHSINVLRDKATGISKGC 400
                                 ||:|:||:|:::||..|:.:|||:|.::.:.||:|:.||:.|||
  Rat    54 ---------------------IKLFIGQIPRNLDEKDLKPLFEEFGKIYELTVLKDRFTGMHKGC 97

  Fly   401 CFVTFYTRHAALKAQDALHNVKTLNGMYHPIQMKPADSENR-----------NERKLFVGMLNKK 454
            .|:|:..|.:|||||.|||..|||.||..|||:||||||:|           .:||||||||||:
  Rat    98 AFLTYCERESALKAQSALHEQKTLPGMNRPIQVKPADSESRGGSSCLRQPPSQDRKLFVGMLNKQ 162

  Fly   455 LNENDVRKLFEVHGAIEECTVLRDQNGQSKGCAFVTFATKHAAISAIKVTLSQNKIMEGCTSPLV 519
            .:|:|||:|||..|.|||||:||..:|.|||||||.::: ||...|....|..::.|.|.:|.||
  Rat   163 QSEDDVRRLFEAFGNIEECTILRGPDGNSKGCAFVKYSS-HAEAQAAINALHGSQTMPGASSSLV 226

  Fly   520 VKFADTQKEKEQKKIQQIQANLWNLASNINIPLGQTATSVTTPILPNPPQQPSPVLGADAITPAS 584
            ||||||.||:..:::||:              .||..       :.||...|....||.|
  Rat   227 VKFADTDKERTMRRMQQM--------------AGQMG-------MFNPMAIPFGAYGAYA----- 265

  Fly   585 IQLLQQLQAVGLQHQLLQALTGLGAQQSSSATDTSAVAAAGLLTPMTVQNLAAIAAMTQPSLSNA 649
             |.|.|.||..:                      ::||..|.|.||.....|.:..|...:::..
  Rat   266 -QALMQQQAALM----------------------ASVAQGGYLNPMAAFAAAQMQQMAALNMNGL 307

  Fly   650 AAAAAAATSPGSAQLTNTAALLWSDPNPMA---------------SAYMSTAAGLPQFGSASALS 699
            |||....||.||.....||..:.|.|:|:.               :|....|.|:..:.:.|..:
  Rat   308 AAAPMTPTSGGSTPPGITAPAVPSIPSPIGVNGFTGLPPQANGQPAAEAVFANGIHPYPAQSPTA 372

  Fly   700 TSPLASV-------ALSAAAAAAAG---------------KQIEGPEGCNLFIYHLPQEFTDTDL 742
            ..||...       |..||..||.|               :|.||||||||.||||||||.|.:|
  Rat   373 ADPLQQAYAGVQQYAGPAAYPAAYGQISQAFPQPPPMIPQQQREGPEGCNLLIYHLPQEFGDAEL 437

  Fly   743 ASTFLPFGNVISAKVFIDKQTSLSKCFG 770
            ...|||||||||:|||:|:.|:.|||||
  Rat   438 MQMFLPFGNVISSKVFVDRATNQSKCFG 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bru1	NP_001260403.1	RRM1_CELF1_2_Bruno	356..437	CDD:241075	42/80 (53%)
		ELAV_HUD_SF	359..808	CDD:273741	180/460 (39%)
		RRM2_Bruno_like	443..524	CDD:241080	45/80 (56%)
		RRM3_Bruno_like	722..800	CDD:241084	36/49 (73%)
Celf4	XP_038952808.1	RRM1_CELF3_4_5_6	49..135	CDD:410041	46/106 (43%)
		PABP-1234	<56..378	CDD:130689	136/371 (37%)
		RRM2_CELF3_4_5_6	151..231	CDD:410043	45/80 (56%)
		RRM_SF	417..>465	CDD:418427	34/47 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340077
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0144
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1209165at2759
OrthoFinder	1	1.000	-	-		FOG0000286
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X208
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750