DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bru1 and Celf2

DIOPT Version :9

Sequence 1:	NP_001260403.1	Gene:	bru1 / 34648	FlyBaseID:	FBgn0000114	Length:	810	Species:	Drosophila melanogaster
Sequence 2:	XP_030103179.1	Gene:	Celf2 / 14007	MGIID:	1338822	Length:	536	Species:	Mus musculus

Alignment Length:	516	Identity:	252/516 - (48%)
Similarity:	317/516 - (61%)	Gaps:	87/516 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   351 EPDPDNIKMFVGQVPKSMDESQLREMFEEYGAVHSINVLRDKATG--ISKGCCFVTFYTRHAALK 413
            :||||.|||||||:|:|..|.:|:|:||.||||:.||||||::..  .||||||||||||.|||:
Mouse    52 QPDPDAIKMFVGQIPRSWSEKELKELFEPYGAVYQINVLRDRSQNPPQSKGCCFVTFYTRKAALE 116

  Fly   414 AQDALHNVKTLNGMYHPIQMKPADSENRN---ERKLFVGMLNKKLNENDVRKLFEVHGAIEECTV 475
            ||:||||:|||.||:|||||||||||..|   :||||:||::||.||||:|.:|...|.||||.:
Mouse   117 AQNALHNIKTLPGMHHPIQMKPADSEKSNAVEDRKLFIGMVSKKCNENDIRVMFSPFGQIEECRI 181

  Fly   476 LRDQNGQSKGCAFVTFATKHAAISAIKVTLSQNKIMEGCTSPLVVKFADTQKEKEQKKIQQIQAN 540
            ||..:|.|:|||||||:|:..|.:||| .:.|::.||||:||:|||||||||:|||:::||
Mouse   182 LRGPDGLSRGCAFVTFSTRAMAQNAIK-AMHQSQTMEGCSSPIVVKFADTQKDKEQRRLQQ---- 241

  Fly   541 LWNLASNINIPLGQTATSVTTPILPNPPQQPSPVLGADAITPASIQLLQQL-------------Q 592
                      .|.|....:.|....|       :.|...:||..:.||||.             |
Mouse   242 ----------QLAQQMQQLNTATWGN-------LTGLGGLTPQYLALLQQATSSSNLGAFSGIQQ 289

  Fly   593 AVG---LQHQLLQALTGLGAQQSSSATDTSAVAAAGLLTPMTVQNLAAIAAMTQP---SLSNAAA 651
            ..|   ||.|.|..|....|...:|||.|:|       .|:: ...:|:.|:|.|   |..|:.|
Mouse   290 MAGMNALQLQNLATLAAAAAAAQTSATSTNA-------NPLS-STSSALGALTSPVAASTPNSTA 346

  Fly   652 AAA--AATSPGSAQLTNTAALLWSDPNPMAS----AYMST----------AAGLPQFGSASALS- 699
            .||  :.||.|:.|....|.:..::.|.:|.    |.|.:          |.||.. |:|..:.
Mouse   347 GAAMNSLTSLGTLQGLAGATVGLNNINALAGTINIAQMLSGMAALNGGLGATGLTN-GTAGTMDA 410

  Fly   700 -TSPLASVALSAAAA-------------AAAGKQIEGPEGCNLFIYHLPQEFTDTDLASTFLPFG 750
             |...:.:...||||             :|||.|.|||||.|||||||||||.|.|:...|:|||
Mouse   411 LTQAYSGIQQYAAAALPTLYSQSLLQQQSAAGSQKEGPEGANLFIYHLPQEFGDQDILQMFMPFG 475

  Fly   751 NVISAKVFIDKQTSLSKCFGFVSFDNPDSAQVAIKAMNGFQVGTKRLKVQLKKPK-DSKPY 810
            |||||||||||||:|||||||||:|||.|||.||:||||||:|.||||||||:.| |||||
Mouse   476 NVISAKVFIDKQTNLSKCFGFVSYDNPVSAQAAIQAMNGFQIGMKRLKVQLKRSKNDSKPY 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bru1	NP_001260403.1	RRM1_CELF1_2_Bruno	356..437	CDD:241075	57/82 (70%)
		ELAV_HUD_SF	359..808	CDD:273741	242/504 (48%)
		RRM2_Bruno_like	443..524	CDD:241080	46/80 (58%)
		RRM3_Bruno_like	722..800	CDD:241084	62/77 (81%)
Celf2	XP_030103179.1	RRM1_CELF1_2_Bruno	57..140	CDD:241075	57/82 (70%)
		RRM2_CELF1_2	149..229	CDD:241078	46/80 (58%)
		RRM3_CELF1_2	444..535	CDD:241082	71/90 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836407
Domainoid	1	1.000	97	1.000	Domainoid score	I7221
eggNOG	1	0.900	-	-		E1_KOG0144
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4783
Inparanoid	1	1.050	405	1.000	Inparanoid score	I1883
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000286
OrthoInspector	1	1.000	-	-		otm43470
orthoMCL	1	0.900	-	-		OOG6_106127
Panther	1	1.100	-	-	O	PTHR24012
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2990
SonicParanoid	1	1.000	-	-		X208
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.780