DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bru1 and CELF3

DIOPT Version :9

Sequence 1:	NP_001260403.1	Gene:	bru1 / 34648	FlyBaseID:	FBgn0000114	Length:	810	Species:	Drosophila melanogaster
Sequence 2:	NP_009116.3	Gene:	CELF3 / 11189	HGNCID:	11967	Length:	465	Species:	Homo sapiens

Alignment Length:	500	Identity:	213/500 - (42%)
Similarity:	289/500 - (57%)	Gaps:	79/500 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   353 DPDNIKMFVGQVPKSMDESQLREMFEEYGAVHSINVLRDKATGISKGCCFVTFYTRHAALKAQDA 417
            :||.||:||||:|:.::|..|:.:||::|.:..:.|::||.||:.|||.|:|:..|.:|||||.|
Human     3 EPDAIKLFVGQIPRHLEEKDLKPIFEQFGRIFELTVIKDKYTGLHKGCAFLTYCARDSALKAQSA 67

  Fly   418 LHNVKTLNGMYHPIQMKPADSENRNE-RKLFVGMLNKKLNENDVRKLFEVHGAIEECTVLRDQNG 481
            ||..|||.||..|||:||||||:|.| ||||||||.|:..:.||||:||..|.|:||||||..:|
Human    68 LHEQKTLPGMNRPIQVKPADSESRGEDRKLFVGMLGKQQTDEDVRKMFEPFGTIDECTVLRGPDG 132

  Fly   482 QSKGCAFVTFATKHAAISAIKVTLSQNKIMEGCTSPLVVKFADTQKEKEQKKIQQIQANLWNLAS 546
            .|||||||.|.| ||...|...||..::.:.|.:|.||||||||:||:..:::||:...| .:.|
Human   133 TSKGCAFVKFQT-HAEAQAAINTLHSSRTLPGASSSLVVKFADTEKERGLRRMQQVATQL-GMFS 195

  Fly   547 NINIPLGQTATSVTTPILPNPPQQPSPVLGADAITPASIQLLQQLQAVGLQHQLLQALTGLGAQQ 611
            .|.:..|  |.|..|..|   .||.:.::.|.:   |.:..:..:.||.:||.
Human   196 PIALQFG--AYSAYTQAL---MQQQAALVAAHS---AYLSPMATMAAVQMQHM------------ 240

  Fly   612 SSSATDTSAVAAAGLL-TPMTVQNLAAIAAMTQPSLSNAAAAAAAAT------SPGSAQLTNTAA 669
                   :|:.|.||: ||:|..:    ...|.|:::....:|..|.      ||...|.|...|
Human   241 -------AAINANGLIATPITPSS----GTSTPPAIAATPVSAIPAALGVNGYSPVPTQPTGQPA 294

  Fly   670 LLWSDPN---------------PMASAYMSTAAGLPQFGSASALSTSPLASVALSAAAAAA---- 715
            .....||               |:..||    ||:..:.:|...:.|.:|.......|..|
Human   295 PDALYPNGVHPYPAQSPAAPVDPLQQAY----AGMQHYTAAYPAAYSLVAPAFPQPPALVAQQPP 355

  Fly   716 --------------AGKQIEGPEGCNLFIYHLPQEFTDTDLASTFLPFGNVISAKVFIDKQTSLS 766
                          ..:|.|||:|||:|||||||||||:::...|:|||:|||||||:|:.|:.|
Human   356 PPPQQQQQQQQQQQQQQQREGPDGCNIFIYHLPQEFTDSEILQMFVPFGHVISAKVFVDRATNQS 420

  Fly   767 KCFGFVSFDNPDSAQVAIKAMNGFQVGTKRLKVQLKKPKD-SKPY 810
            |||||||||||.|||.||:||||||:|.||||||||:||| ::||
Human   421 KCFGFVSFDNPASAQAAIQAMNGFQIGMKRLKVQLKRPKDANRPY 465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bru1	NP_001260403.1	RRM1_CELF1_2_Bruno	356..437	CDD:241075	41/80 (51%)
		ELAV_HUD_SF	359..808	CDD:273741	207/490 (42%)
		RRM2_Bruno_like	443..524	CDD:241080	46/81 (57%)
		RRM3_Bruno_like	722..800	CDD:241084	57/77 (74%)
CELF3	NP_009116.3	RRM1_CELF3_4_5_6	2..88	CDD:410041	44/84 (52%)
		RRM2_CELF3_4_5_6	94..174	CDD:410043	45/80 (56%)
		PRK12323	<214..>351	CDD:237057	34/166 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	346..379		6/32 (19%)
		RRM3_CELF3_4_5_6	376..454	CDD:241083	57/77 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146320
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0144
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1209165at2759
OrthoFinder	1	1.000	-	-		FOG0000286
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X208
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750