DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bru1 and Celf4

DIOPT Version :9

Sequence 1:	NP_001260403.1	Gene:	bru1 / 34648	FlyBaseID:	FBgn0000114	Length:	810	Species:	Drosophila melanogaster
Sequence 2:	NP_001349204.1	Gene:	Celf4 / 108013	MGIID:	1932407	Length:	554	Species:	Mus musculus

Alignment Length:	584	Identity:	209/584 - (35%)
Similarity:	287/584 - (49%)	Gaps:	146/584 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   271 SNGTSSNNSLNVGNNNSNPSLGGSNSNALVSVGSNGIMSAAGLVNNNNNPCSANRNVVAMVDDDA 335
            :||.:.|.||:.....|:|             ||.|.|:  ||.::..||     :.:.|.|.||
Mouse     9 ANGQADNASLSTNGLGSSP-------------GSAGHMN--GLSHSPGNP-----STIPMKDHDA 53

  Fly   336 CFRLDTDATVTYGEKEPDPDNIKMFVGQVPKSMDESQLREMFEEYGAVHSINVLRDKATGISKGC 400
                                 ||:|:||:|:::||..|:.:|||:|.::.:.||:|:.||:.|||
Mouse    54 ---------------------IKLFIGQIPRNLDEKDLKPLFEEFGKIYELTVLKDRFTGMHKGC 97

  Fly   401 CFVTFYTRHAALKAQDALHNVKTLNGMYHPIQMKPADSENR----------NERKLFVGMLNKKL 455
            .|:|:..|.:|||||.|||..|||.||..|||:||||||:|          :.||||||||||:.
Mouse    98 AFLTYCERESALKAQSALHEQKTLPGMNRPIQVKPADSESRGGSSCLRQPPSHRKLFVGMLNKQQ 162

  Fly   456 NENDVRKLFEVHGAIEECTVLRDQNGQSKGCAFVTFATKHAAISAIKVTLSQNKIMEGCTSPLVV 520
            :|:|||:|||..|.|||||:||..:|.|||||||.::: ||...|....|..::.|.|.:|.|||
Mouse   163 SEDDVRRLFEAFGNIEECTILRGPDGNSKGCAFVKYSS-HAEAQAAINALHGSQTMPGASSSLVV 226

  Fly   521 KFADTQKEKEQKKIQQIQANLWNLASNINIPLGQTATSVTTPILPNPPQQPSPVLGADAITPASI 585
            |||||.||:..:::||:              .||..       :.||...|....||.|
Mouse   227 KFADTDKERTMRRMQQM--------------AGQMG-------MFNPMAIPFGAYGAYA------ 264

  Fly   586 QLLQQLQAVGLQHQLLQALTGLGAQQSSSATDTSAVAAAGLLTPMTVQNLAAIAAMTQPSLSNAA 650
            |.|.|.||..:                      ::||..|.|.||.....|.:..|...:::..|
Mouse   265 QALMQQQAALM----------------------ASVAQGGYLNPMAAFAAAQMQQMAALNMNGLA 307

  Fly   651 AAAAAATSPGSAQLTNTAALLWSDPNPMA---------------SAYMSTAAGLPQFGSASALST 700
            ||....||.||.....||..:.|.|:|:.               :|....|.|:..:.:.|..:.
Mouse   308 AAPMTPTSGGSTPPGITAPAVPSIPSPIGVNGFTGLPPQANGQPAAEAVFANGIHPYPAQSPTAA 372

  Fly   701 SPL----ASVALSAAAA--AAAG---------------KQIEGPEGCNLFIYHLPQEFTDTDLAS 744
            .||    |.|...|..|  ||.|               :|.||||||||.||||||||.|.:|..
Mouse   373 DPLQQAYAGVQQYAGPAYPAAYGQISQAFPQPPPMIPQQQREGPEGCNLLIYHLPQEFGDAELMQ 437

  Fly   745 TFLPFGNVISAKVFIDKQTSLSKCFGFVSFDNPDSAQVAIKAMNGFQV----GTKRLKVQLKKP 804
            .|||||||||:|||:|:.|:.|||||    .:|..::....:..|.|.    ..:||: :|::|
Mouse   438 MFLPFGNVISSKVFVDRATNQSKCFG----RHPVPSRCQAPSCQGGQCAISSSARRLR-ELRQP 496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bru1	NP_001260403.1	RRM1_CELF1_2_Bruno	356..437	CDD:241075	42/80 (53%)
		ELAV_HUD_SF	359..808	CDD:273741	188/496 (38%)
		RRM2_Bruno_like	443..524	CDD:241080	45/80 (56%)
		RRM3_Bruno_like	722..800	CDD:241084	41/81 (51%)
Celf4	NP_001349204.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..39		9/35 (26%)
		RRM1_CELF3_4_5_6	49..135	CDD:241076	46/106 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..149		13/27 (48%)
		RRM2_CELF3_4_5_6	150..230	CDD:241079	45/80 (56%)
		Necessary for TNNT2 exon 5 inclusion. /evidence=ECO:0000250	238..257		6/39 (15%)
		RRM_SF	415..>463	CDD:388407	34/47 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836405
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0144
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1209165at2759
OrthoFinder	1	1.000	-	-		FOG0000286
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X208
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.750