DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bru1 and CELF2

DIOPT Version :9

Sequence 1:	NP_001260403.1	Gene:	bru1 / 34648	FlyBaseID:	FBgn0000114	Length:	810	Species:	Drosophila melanogaster
Sequence 2:	XP_024303540.1	Gene:	CELF2 / 10659	HGNCID:	2550	Length:	549	Species:	Homo sapiens

Alignment Length:	516	Identity:	252/516 - (48%)
Similarity:	318/516 - (61%)	Gaps:	87/516 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   351 EPDPDNIKMFVGQVPKSMDESQLREMFEEYGAVHSINVLRDKATG--ISKGCCFVTFYTRHAALK 413
            :||||.|||||||:|:|..|.:|:|:||.||||:.||||||::..  .||||||||||||.|||:
Human    65 QPDPDAIKMFVGQIPRSWSEKELKELFEPYGAVYQINVLRDRSQNPPQSKGCCFVTFYTRKAALE 129

  Fly   414 AQDALHNVKTLNGMYHPIQMKPADSENRN---ERKLFVGMLNKKLNENDVRKLFEVHGAIEECTV 475
            ||:||||:|||.||:|||||||||||..|   :||||:||::||.||||:|.:|...|.||||.:
Human   130 AQNALHNIKTLPGMHHPIQMKPADSEKSNAVEDRKLFIGMVSKKCNENDIRVMFSPFGQIEECRI 194

  Fly   476 LRDQNGQSKGCAFVTFATKHAAISAIKVTLSQNKIMEGCTSPLVVKFADTQKEKEQKKIQQIQAN 540
            ||..:|.|:|||||||:|:..|.:||| .:.|::.||||:||:|||||||||:|||:::||
Human   195 LRGPDGLSRGCAFVTFSTRAMAQNAIK-AMHQSQTMEGCSSPIVVKFADTQKDKEQRRLQQ---- 254

  Fly   541 LWNLASNINIPLGQTATSVTTPILPNPPQQPSPVLGADAITPASIQLLQQL-------------Q 592
                      .|.|....:.|....|       :.|...:||..:.||||.             |
Human   255 ----------QLAQQMQQLNTATWGN-------LTGLGGLTPQYLALLQQATSSSNLGAFSGIQQ 302

  Fly   593 AVG---LQHQLLQALTGLGAQQSSSATDTSAVAAAGLLTPMTVQNLAAIAAMTQP---SLSNAAA 651
            ..|   ||.|.|..|....|...:|||.|:|       .|::..: :|:.|:|.|   |..|:.|
Human   303 MAGMNALQLQNLATLAAAAAAAQTSATSTNA-------NPLSTTS-SALGALTSPVAASTPNSTA 359

  Fly   652 AAA--AATSPGSAQLTNTAALLWSDPNPMAS----AYMST----------AAGLPQFGSASALS- 699
            .||  :.||.|:.|....|.:..::.|.:|.    |.|.:          |.||.. |:|..:.
Human   360 GAAMNSLTSLGTLQGLAGATVGLNNINALAGTINIAQMLSGMAALNGGLGATGLTN-GTAGTMDA 423

  Fly   700 -TSPLASVALSAAAA-------------AAAGKQIEGPEGCNLFIYHLPQEFTDTDLASTFLPFG 750
             |...:.:...||||             :|||.|.|||||.|||||||||||.|.|:...|:|||
Human   424 LTQAYSGIQQYAAAALPTLYSQSLLQQQSAAGSQKEGPEGANLFIYHLPQEFGDQDILQMFMPFG 488

  Fly   751 NVISAKVFIDKQTSLSKCFGFVSFDNPDSAQVAIKAMNGFQVGTKRLKVQLKKPK-DSKPY 810
            |||||||||||||:|||||||||:|||.|||.||:||||||:|.||||||||:.| |||||
Human   489 NVISAKVFIDKQTNLSKCFGFVSYDNPVSAQAAIQAMNGFQIGMKRLKVQLKRSKNDSKPY 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bru1	NP_001260403.1	RRM1_CELF1_2_Bruno	356..437	CDD:241075	57/82 (70%)
		ELAV_HUD_SF	359..808	CDD:273741	242/504 (48%)
		RRM2_Bruno_like	443..524	CDD:241080	46/80 (58%)
		RRM3_Bruno_like	722..800	CDD:241084	62/77 (81%)
CELF2	XP_024303540.1	RRM1_CELF1_2_Bruno	70..153	CDD:241075	57/82 (70%)
		RRM2_CELF1_2	162..242	CDD:241078	46/80 (58%)
		RRM3_CELF1_2	457..548	CDD:241082	71/90 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146324
Domainoid	1	1.000	97	1.000	Domainoid score	I7253
eggNOG	1	0.900	-	-		E1_KOG0144
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4783
Inparanoid	1	1.050	405	1.000	Inparanoid score	I1906
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1209165at2759
OrthoFinder	1	1.000	-	-		FOG0000286
OrthoInspector	1	1.000	-	-		otm41419
orthoMCL	1	0.900	-	-		OOG6_106127
Panther	1	1.100	-	-	O	PTHR24012
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2990
SonicParanoid	1	1.000	-	-		X208
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.830