Protein Alignment bru1 and CELF1

DIOPT Version :10

• Sequence 1: NP_723737.1
• Gene: bru1 / 34648
• FlyBaseID: FBgn0000114
• Length: 810
• Species: Drosophila melanogaster
• Sequence 2: NP_001317201.1
• Gene: CELF1 / 10658
• HGNCID: 2549
• Length: 514
• Species: Homo sapiens
• Alignment Length: 562
• Identity: 256/562 - (45%)
• Similarity: 321/562 - (57%)
• Gaps: 136/562 - (24%)

  Fly   321 CSANRNVVAMVDDDACFRLDTDATVTYGEKEPDPDNIKMFVGQVPKSMDESQLREMFEEYGAVHS 385
            ||.|.:.|:.         ..:.|:.:.: :||.|.|||||||||::..|..|||:||:||||:.
Human    17 CSLNSSPVSK---------KMNGTLDHPD-QPDLDAIKMFVGQVPRTWSEKDLRELFEQYGAVYE 71

  Fly   386 INVLRDKATG--ISKGCCFVTFYTRHAALKAQDALHNVKTLNGMYHPIQMKPADSENRN---ERK 445
            ||||||::..  .||||||||||||.|||:||:||||:|.|.||:|||||||||||..|   :||
Human    72 INVLRDRSQNPPQSKGCCFVTFYTRKAALEAQNALHNMKVLPGMHHPIQMKPADSEKNNAVEDRK 136

  Fly   446 LFVGMLNKKLNENDVRKLFEVHGAIEECTVLRDQNGQSKGCAFVTFATKHAAISAIKVTLSQNKI 510
            ||:||::||..|||:|.:|...|.||||.:||..:|.|:|||||||.|:..|.:||| .:.|.:.
Human   137 LFIGMISKKCTENDIRVMFSSFGQIEECRILRGPDGLSRGCAFVTFTTRAMAQTAIK-AMHQAQT 200

  Fly   511 MEGCTSPLVVKFADTQKEKEQKKI-QQIQ--------ANLW-NLASNINIPLGQTATSVTTPILP 565
            ||||:||:|||||||||:||||:: ||:|        |::| |||
Human   201 MEGCSSPMVVKFADTQKDKEQKRMAQQLQQQMQQISAASVWGNLA-------------------- 245

  Fly   566 NPPQQPSPVLGADAITPASIQLLQQLQAVGLQHQLLQALTGLGAQQSSSATDTSAVAAAGLLTPM 630
                      |.:.:.|         |.:.|..||||.     ...|.:....|::...|.|..|
Human   246 ----------GLNTLGP---------QYLALYLQLLQQ-----TASSGNLNTLSSLHPMGGLNAM 286

  Fly   631 TVQNLAAIAAMTQPSLSNAAAAAAAATSPGSAQLTNTAALL-------WSDP--------NPMAS 680
            .:|||||:|         |||:||..|..|:..||.:::.|       .|.|        ||:||
Human   287 QLQNLAALA---------AAASAAQNTPSGTNALTTSSSPLSVLTSSAGSSPSSSSSNSVNPIAS 342

  Fly   681 -AYMSTAAGLP---QFGS------------ASALS----------TSPLASVALSAAAA------ 713
             ..:.|.||..   ..||            :|.||          |...:.:...||||
Human   343 LGALQTLAGATAGLNVGSLAGMAALNGGLGSSGLSNGTGSTMEALTQAYSGIQQYAAAALPTLYN 407

  Fly   714 ---------AAAGKQIEGPEGCNLFIYHLPQEFTDTDLASTFLPFGNVISAKVFIDKQTSLSKCF 769
                     .|||.|.|||||.|||||||||||.|.||...|:|||||:||||||||||:|||||
Human   408 QNLLTQQSIGAAGSQKEGPEGANLFIYHLPQEFGDQDLLQMFMPFGNVVSAKVFIDKQTNLSKCF 472

  Fly   770 GFVSFDNPDSAQVAIKAMNGFQVGTKRLKVQLKKPK-DSKPY 810
            ||||:|||.|||.||::|||||:|.||||||||:.| |||||
Human   473 GFVSYDNPVSAQAAIQSMNGFQIGMKRLKVQLKRSKNDSKPY 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bru1	NP_723737.1	RRM1_CELF1_2_Bruno	356..437	CDD:410040	57/82 (70%)
		SF-CC1	<435..789	CDD:273721	173/422 (41%)
		RRM_SF	443..524	CDD:473069	45/80 (56%)
		RRM3_Bruno_like	722..800	CDD:241084	61/77 (79%)
CELF1	NP_001317201.1	RRM1_CELF1_2_Bruno	42..125	CDD:410040	57/82 (70%)
		RRM2_CELF1_2	134..214	CDD:410042	45/80 (56%)
		RRM3_CELF1_2	422..513	CDD:241082	70/90 (78%)