DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment bru1 and celf5b

DIOPT Version :9

Sequence 1:	NP_001260403.1	Gene:	bru1 / 34648	FlyBaseID:	FBgn0000114	Length:	810	Species:	Drosophila melanogaster
Sequence 2:	XP_021322092.1	Gene:	celf5b / 101884815	ZFINID:	ZDB-GENE-070912-150	Length:	334	Species:	Danio rerio

Alignment Length:	378	Identity:	160/378 - (42%)
Similarity:	215/378 - (56%)	Gaps:	58/378 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   443 ERKLFVGMLNKKLNENDVRKLFEVHGAIEECTVLRDQNGQSKGCAFVTFATKHAAISAIKVTLSQ 507
            :||||||||||:..|.||.:|||.:|.||||||||..:|.|||||||.|:|...|.|||. .|..
Zfish     5 DRKLFVGMLNKQQTEEDVYRLFEPYGVIEECTVLRGPDGNSKGCAFVKFSTHTEAQSAIG-GLHG 68

  Fly   508 NKIMEGCTSPLVVKFADTQKEKEQKKIQQIQANLWNLASNINIPLGQTATSVTTPILPNPPQQPS 572
            ::.|.|.:|.||||||||.||:..:::||:.........::.:|....:::.:|
Zfish    69 SQTMPGASSSLVVKFADTDKERTIRRMQQMVGQFGIFNPSVALPFSTYSSTYST----------- 122

  Fly   573 PVLGADAITPASIQLLQQLQAVGLQHQLLQALTGLGAQQSSSATDTSAVAAAGLL-------TPM 630
                   .|.|   |:||..|:       .|.:..|....|.|...:.:...|.|       |||
Zfish   123 -------YTHA---LMQQQAAI-------MAASHGGYLAPSVAFPATQIHQVGALNMNGLPPTPM 170

  Fly   631 TVQNLAAIAAMTQPSLSNAAAAAAAATSPGSAQLTNTAALLWSDPN--PMASAYMSTAAGLPQFG 693
            |     .::.::.|..:.|::|..:..:|    :.|..:.:...||  |:.:.|.:   |||.:.
Zfish   171 T-----PVSGLSSPPANLASSAVPSIVTP----IVNGFSGIPHQPNGHPVEAVYTN---GLPPYS 223

  Fly   694 SASALSTSPLASVALSAAAAAAAGKQIEGPEGCNLFIYHLPQEFTDTDLASTFLPFGNVISAKVF 758
                 :.||.|:..|..|....  :|..||||||||||||||||.|.:|...|||||:|||:|||
Zfish   224 -----TQSPTAADTLQQAFTGV--QQYTGPEGCNLFIYHLPQEFGDNELMQMFLPFGSVISSKVF 281

  Fly   759 IDKQTSLSKCFGFVSFDNPDSAQVAIKAMNGFQVGTKRLKVQLKKPKD-SKPY 810
            :|:.|:.||||||||||||.|||.||:||||||:|.||||||||:||| |:||
Zfish   282 MDRATNQSKCFGFVSFDNPASAQAAIQAMNGFQIGMKRLKVQLKRPKDASRPY 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bru1	NP_001260403.1	RRM1_CELF1_2_Bruno	356..437	CDD:241075
		ELAV_HUD_SF	359..808	CDD:273741	157/374 (42%)
		RRM2_Bruno_like	443..524	CDD:241080	48/80 (60%)
		RRM3_Bruno_like	722..800	CDD:241084	59/77 (77%)
celf5b	XP_021322092.1	RRM	<2..330	CDD:330708	156/372 (42%)
		RRM2_CELF3_4_5_6	5..85	CDD:241079	48/80 (60%)
		RRM3_CELF3_4_5_6	245..323	CDD:241083	59/77 (77%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1209165at2759
OrthoFinder	1	1.000	-	-		FOG0000286
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X208
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920