DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bru1 and celf3b

DIOPT Version :9

Sequence 1:	NP_001260403.1	Gene:	bru1 / 34648	FlyBaseID:	FBgn0000114	Length:	810	Species:	Drosophila melanogaster
Sequence 2:	XP_021322469.1	Gene:	celf3b / 100333973	ZFINID:	ZDB-GENE-110408-50	Length:	442	Species:	Danio rerio

Alignment Length:	489	Identity:	221/489 - (45%)
Similarity:	290/489 - (59%)	Gaps:	80/489 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   353 DPDNIKMFVGQVPKSMDESQLREMFEEYGAVHSINVLRDKATGISKGCCFVTFYTRHAALKAQDA 417
            :||.||:|:||:|::::|..|:.:||:||.::.:.|::||.||:.|||.|:|:..|.:|:|||.|
Zfish     3 EPDAIKLFIGQIPRNLEEKDLKPIFEQYGKIYELTVIKDKYTGMHKGCAFLTYCARESAVKAQSA 67

  Fly   418 LHNVKTLNGMYHPIQMKPADSENRNE-RKLFVGMLNKKLNENDVRKLFEVHGAIEECTVLRDQNG 481
            ||..|||.||..|||:||||||.|.| ||||||||.|:.::.||||:||..|.|:||||||..:|
Zfish    68 LHEQKTLPGMNRPIQVKPADSEGRGEDRKLFVGMLGKQQSDEDVRKIFEPFGGIDECTVLRGPDG 132

  Fly   482 QSKGCAFVTFATKHAAISAIKVTLSQNKIMEGCTSPLVVKFADTQKEKEQKKIQQIQANLWNLAS 546
            .|||||||.|.:...|.|||. :|..::.:.|.:|.||||||||:||:..:::||:.:.|
Zfish   133 TSKGCAFVKFQSHSEAQSAIN-SLHGSRTLPGASSSLVVKFADTEKERGVRRMQQVTSQL----- 191

  Fly   547 NINIPLGQTATSVTTPILPNPPQQPSPVLGADAITPASIQLLQQLQAVGLQHQLLQALTGLGAQQ 611
                       .|.||:          .|..:|.. |..|.|.|.||:..|.|.|.....:..||
Zfish   192 -----------GVYTPV----------TLNFNAYN-AYTQALVQQQALVAQAQYLSPAASMQIQQ 234

  Fly   612 SSSATDTSAVAA-----AGLLTPMTVQNLAA--IAAMTQPSLSNAAAAAAAATS--PGSAQLTN- 666
            .::...:..:|.     :|..||.|   |||  ::|:.||...|..:.....|:  |.|...||
Zfish   235 MAALNASGIIATPITPPSGANTPPT---LAATPVSALPQPIAVNGYSHLPPTTNGQPASEIYTNG 296

  Fly   667 ---------TAALLWSDPNPMASAYMS-------TAAGL--PQF-GSASALSTSPLASVALSAAA 712
                     .|||   ||...|.|.|.       ||.||  ||| ...:.:|...|
Zfish   297 LHPYQAQSPVAAL---DPLQQAYAGMQHYTAAYPTAYGLVSPQFLQQPTLISQQQL--------- 349

  Fly   713 AAAAGKQIEGPEGCNLFIYHLPQEFTDTDLASTFLPFGNVISAKVFIDKQTSLSKCFGFVSFDNP 777
                  |.|||||||:|||||||||||:::...|||||||||||||:|:.|:.||||||||||||
Zfish   350 ------QREGPEGCNVFIYHLPQEFTDSEMLQMFLPFGNVISAKVFVDRATNQSKCFGFVSFDNP 408

  Fly   778 DSAQVAIKAMNGFQVGTKRLKVQLKKPKD-SKPY 810
            .|||.||:||||||:|.||||||||:||| ::||
Zfish   409 ASAQTAIQAMNGFQIGMKRLKVQLKRPKDANRPY 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bru1	NP_001260403.1	RRM1_CELF1_2_Bruno	356..437	CDD:241075	40/80 (50%)
		ELAV_HUD_SF	359..808	CDD:273741	215/479 (45%)
		RRM2_Bruno_like	443..524	CDD:241080	45/81 (56%)
		RRM3_Bruno_like	722..800	CDD:241084	60/77 (78%)
celf3b	XP_021322469.1	RRM1_CELF3_4_5_6	2..88	CDD:241076	43/84 (51%)
		RRM2_CELF3_4_5_6	94..174	CDD:241079	44/80 (55%)
		EBV-NA3	<226..417	CDD:332796	87/211 (41%)
		RRM3_CELF3_4_5_6	353..431	CDD:241083	60/77 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579915
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0144
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1209165at2759
OrthoFinder	1	1.000	-	-		FOG0000286
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X208
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.750