DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bru1 and celf5

DIOPT Version :9

Sequence 1:	NP_001260403.1	Gene:	bru1 / 34648	FlyBaseID:	FBgn0000114	Length:	810	Species:	Drosophila melanogaster
Sequence 2:	NP_001090639.1	Gene:	celf5 / 100036604	XenbaseID:	XB-GENE-494002	Length:	486	Species:	Xenopus tropicalis

Alignment Length:	497	Identity:	208/497 - (41%)
Similarity:	283/497 - (56%)	Gaps:	56/497 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   335 ACFRLDTDATVTYGEKEPDPDNIKMFVGQVPKSMDESQLREMFEEYGAVHSINVLRDKATGISKG 399
            ||.....:......:...|.|.||:||||:|::::|..|:.:||::|.::.:.||:|:.||:.||
Frog    25 ACPMSGPEPPAQQSDSMKDLDAIKLFVGQIPRNLEEKDLKPLFEQFGKIYELTVLKDRYTGMHKG 89

  Fly   400 CCFVTFYTRHAALKAQDALHNVKTLNGMYHPIQMKPADSENR-NERKLFVGMLNKKLNENDVRKL 463
            |.|:|:..|.:|:|||.|||..|||.||..|||:||||||:| .:||||||||:|:.:|.:|..:
Frog    90 CAFLTYCARDSAIKAQTALHEQKTLPGMARPIQVKPADSESRGGDRKLFVGMLSKQQSEEEVTSM 154

  Fly   464 FEVHGAIEECTVLRDQNGQSKGCAFVTFATKHAAISAIKVTLSQNKIMEGCTSPLVVKFADTQKE 528
            |:..|:||||:|||..:|.|||||||.|:: ||...|....|..::.|.|.:|.||||||||.||
Frog   155 FQAFGSIEECSVLRGPDGSSKGCAFVKFSS-HAEAQAAIQALHGSQTMPGASSSLVVKFADTDKE 218

  Fly   529 KEQKKIQQIQANLWNLASNINIPLGQTATSVTTPILPNPP------QQPSPVLG---ADAITPAS 584
            :..:::||:...           ||....|:..||.|...      ||.:.||.   ...::| |
Frog   219 RTLRRMQQMVGQ-----------LGIFTPSLALPISPYSAYAQALMQQQTTVLSTSHGSYLSP-S 271

  Fly   585 IQL----LQQLQAVGLQHQLLQALTGLGAQQSSSATDTSAVAAAGLLTPMT--VQNLAAIAAMTQ 643
            :..    :||:.||.|.......:|......|.....|:||  .||:.|:|  ...|....: :.
Frog   272 VAFPSCHIQQIGAVNLNGLPAAPITPASGLHSPPVIGTAAV--PGLVAPLTNGFPGLVPFPS-SH 333

  Fly   644 PSLSNAAAAAAAATSPGSAQLTNTAALLWSDPNPMASAYMSTAAGLPQFGSASALS----TSPLA 704
            |:|...              .||:..     |.|..|..::..:..|.|......|    |:.|.
Frog   334 PALDTI--------------YTNSIV-----PYPAQSPALTVESLHPSFTGVQQYSAIYPTAALT 379

  Fly   705 SVALSAAAAAAAGKQIEGPEGCNLFIYHLPQEFTDTDLASTFLPFGNVISAKVFIDKQTSLSKCF 769
            .|..|........:|.|||||||||||||||||.|.:|...||||||:||:|||:|:.|:.||||
Frog   380 PVTHSTPQPPPILQQREGPEGCNLFIYHLPQEFGDNELTQMFLPFGNIISSKVFMDRATNQSKCF 444

  Fly   770 GFVSFDNPDSAQVAIKAMNGFQVGTKRLKVQLKKPKD-SKPY 810
            ||||||||.|||.||:||||||:|.||||||||:||| ::||
Frog   445 GFVSFDNPSSAQTAIQAMNGFQIGMKRLKVQLKRPKDTTQPY 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bru1	NP_001260403.1	RRM1_CELF1_2_Bruno	356..437	CDD:241075	40/80 (50%)
		ELAV_HUD_SF	359..808	CDD:273741	200/469 (43%)
		RRM2_Bruno_like	443..524	CDD:241080	41/80 (51%)
		RRM3_Bruno_like	722..800	CDD:241084	59/77 (77%)
celf5	NP_001090639.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..39		2/13 (15%)
		RRM1_CELF3_4_5_6	42..128	CDD:241076	43/85 (51%)
		PABP-1234	<49..374	CDD:130689	128/359 (36%)
		RRM2_CELF3_4_5_6	134..214	CDD:241079	41/80 (51%)
		RRM3_CELF3_4_5_6	397..475	CDD:241083	59/77 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1209165at2759
OrthoFinder	1	1.000	-	-		FOG0000286
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X208
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920