DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31760 and gpr158

DIOPT Version :9

Sequence 1:	NP_723730.2	Gene:	CG31760 / 34642	FlyBaseID:	FBgn0051760	Length:	1093	Species:	Drosophila melanogaster
Sequence 2:	XP_002933190.2	Gene:	gpr158 / 779597	XenbaseID:	XB-GENE-950420	Length:	1291	Species:	Xenopus tropicalis

Alignment Length:	1095	Identity:	251/1095 - (22%)
Similarity:	413/1095 - (37%)	Gaps:	322/1095 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   173 STLYR----PLQVPINSERYESSRQKTDLAAS-----ILQEVGIIRHGG------LSD------- 215
            |.||:    .|:..:.|:.||.|...   .||     :|:.|.|:.||.      |..
Frog    79 SFLYKGAAGELKAALCSQSYELSSLP---GASPGHPTLLRAVDILLHGTNFLNMMLQSNKSREHN 140

  Fly   216 ---------ALAKGLLTDDFITGARILALNLTNGAVQSYVWWVKGTAAEIQRYDEDGLQIGKKPA 271
                     ||.|.:|..:.......:|.|:...:....| :::.|..|.:.:.:| |.......
Frog   141 WERDVEWYYALIKSILEGEPAIFRSAVAFNVEPSSHVPQV-FLRATREEGKIHLQD-LSASAHGP 203

  Fly   272 GSYPWFDD------ETSSPTLRSPKFAPSPPNNYYKGW--------------WTYPYFSCSQSR- 315
            |:..|..|      ..|.|.|.  |........:..||              |:.||..|...:
Frog   204 GNATWEHDWLHTFKHRSRPHLH--KRLLHGAKTFDDGWKKGNSYVTDRSHVKWSSPYLECENGKY 266

  Fly   316 ---WLVSYSIAI----PPIGRHGLRGFISIDIDVSTLRVNQCEAEPYPFGSRRQKMQQLQTHNRL 373
               ||:|.|.|.    |.:.|. .||.:.:|:::..:.::||..|.:
Frog   267 RPHWLLSLSAAFYGLKPNLVRE-FRGVLKVDVNLQNIDIDQCSNEGW------------------ 312

  Fly   374 GARRSLFLGSRMGAIDESTINDLQAFHSSHKCHRTSMVCDYRQPSAETPTVTGGKLLTTLTGSSS 438
                                     |..:|:|...|..|        .||...|.:|
Frog   313 -------------------------FSGTHRCQHNSSKC--------IPTKGLGFVL-------- 336

  Fly   439 WTRGSYQCLCRGGFYSLRHPDGF---NGTIMEIAWQEQQDNISNYY------SEVFKCLPCAPGC 494
               |:|:|.|:.|||   :|.|.   ||.        |:.|:.|::      .|.:|||||..||
Frog   337 ---GAYKCTCKAGFY---YPHGMFSENGF--------QRPNMVNHFPRGEISEEEYKCLPCREGC 387

  Fly   495 DTCTGPEPCLANYHWPFRISLLTISIGCACGTFVLAGYLFRHRRVKVFKVASPIFLMITLIGCAI 559
            ..||...||.|......||::::....|....|:....::..||.|..:.:..:.|.:.|.|..:
Frog   388 SNCTDDAPCYAQEDKYLRIAIISFQAFCMLLDFISMLVVYSFRRAKSVRASGLVLLEVILFGSLL 452

  Fly   560 MYLEMVAIFPYLDTTWCIATKWTRHMGFCITYTSLLMKTWRVSLTYRVKSAHKIK-LNDQQLLQW 623
            :|..:|.::....|..||..:|.|.:|:...|.::.:|.:||...:..::|.:|. :...::::.
Frog   453 LYFPVVILYFEPSTFRCILLRWVRLLGYATVYGTVTLKLYRVLKVFLSRTAQRIPYMTSGRVIRM 517

  Fly   624 MVPILLVMLIYLGTWTISATPTAE----VILD---QSQLKFKQCSYNWWDHSLAIGEVFFLAWGI 681
            :..|||::|.:|..||.:.....:    :|:.   ...|:||.|..:.||:.:|:.|..||.||:
Frog   518 LSVILLLVLWFLVAWTSAVCQNMDRNIPLIVQGETSDNLQFKMCLIDRWDYMMAVAEFLFLLWGV 582

  Fly   682 RVCYNVRNAESLYNEARLISYAIYNIALVNIAMVVFHVMLFPNAG---PDYKYMLGFVRTQLSTT 743
            .:||.||...|.::|.|.:::|::|..:.:   .:||.:.|..|.   ||:..||.||.|.|:.|
Frog   583 YLCYAVRTVPSAFHEPRYMAFAVHNELIFS---ALFHTIRFVLASKLQPDWMLMLFFVHTHLTVT 644

  Fly   744 TTIALVFGPKILRVFKGQGDKWDQKAKV---------------RSITASFSLNGVGLVPEESPDL 793
            .|:.|:..||..|......|  |..|:.               .|||:::|        |.|.|
Frog   645 VTVGLLLIPKFSRSHNNPRD--DIAAEAYEDELDLGRSGSYLNSSITSAWS--------EHSLD- 698

  Fly   794 YQENEELKEQVQKLAHQIEFMKTVHMQMNNRHLKPKPGG----------YFTITSTSFQAPYSKN 848
               .|:::|:::||..|:|..|...|..||.||:.|...          ..|....|.....||.
Frog   699 ---PEDIREELKKLYTQLEIYKRKKMIANNPHLQKKRCSKKGLGRSIMRRITEIPDSVSRQCSKE 760

  Fly   849 TVSTAQTQTGKDENSTPTKLKSPKGKVXRGQRSVKDCSIEIDGGQGRTTLVEDAIEFNFHL---A 910
            ...|  |..|..:|:..:..|.|:..| ...:|.::.|      :.:...::.:.....||   :
Frog   761 EKDT--TDHGNPKNNVGSSKKHPQESVTHNAKSKEEPS------KHKLYSMKKSHSSYDHLRSES 817

  Fly   911 DTEKGLIVQE-------------DERP---GSDEE--------------EAALIAQFRRLFAPIL 945
            ||..|:..::             .::|   ||:.|              .|..::..::...|.|
Frog   818 DTPNGISTEKVDVCKNSIYSPVNGKKPNKNGSELEAVSADNVPLVCKSASAHNLSVDKKPLHPSL 882

  Fly   946 --------------DDSLNLYYQLNDLDDTEHVRIHQTVAQMNDLTSSEEETMVTQVNSPSPPPV 996
                          |:||.|..:...::||:  :.|:|     |....|.:..|
Frog   883 SVLQKSLSAVANSKDNSLGLRDKTQSVEDTD--KCHRT-----DSAYHEHQPSV----------- 929

  Fly   997 GVELLLPISSDSSTASSSLYAIHTPSP------AHPSGVLLMPQNLESPLLSGSDAITIT----- 1050
                        :|........||.||      .|.||:  |.|...||.|..|:.. ||
Frog   930 ------------ATFDKEERQQHTSSPIEEIQKLHKSGI--MKQQAMSPHLPESEKF-ITAMGYK 979

  Fly  1051 -----EQV---ELHN-PP---------HHLQL--LEDE-NNTSCSLSSNLTDSKT 1084
                 |:|   |::: ||         .|:.:  ||.| |:||.|.|.:...||:
Frog   980 DKFDIEEVCPWEMYDLPPSVPSENKVQKHVSIAPLESEKNHTSRSKSKSHNRSKS 1034

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31760	NP_723730.2	FU	486..>508	CDD:214589	12/21 (57%)
CG31760	NP_723730.2	7tm_3	526..754	CDD:278433	66/238 (28%)
gpr158	XP_002933190.2	EGF_CA	303..348	CDD:214542	17/106 (16%)
		7tmC_GPR158-like	403..660	CDD:320420	71/259 (27%)
		TM helix 1	403..428	CDD:320420	4/24 (17%)
		TM helix 2	440..461	CDD:320420	5/20 (25%)
		TM helix 3	470..494	CDD:320420	6/23 (26%)
		TM helix 4	514..534	CDD:320420	6/19 (32%)
		TM helix 5	563..589	CDD:320420	10/25 (40%)
		TM helix 6	597..620	CDD:320420	6/25 (24%)
		TM helix 7	629..654	CDD:320420	10/24 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	140	1.000	Domainoid score	I4715
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR32546
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.100