DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31760 and GPR158

DIOPT Version :9

Sequence 1:	NP_723730.2	Gene:	CG31760 / 34642	FlyBaseID:	FBgn0051760	Length:	1093	Species:	Drosophila melanogaster
Sequence 2:	NP_065803.2	Gene:	GPR158 / 57512	HGNCID:	23689	Length:	1215	Species:	Homo sapiens

Alignment Length:	1237	Identity:	248/1237 - (20%)
Similarity:	432/1237 - (34%)	Gaps:	358/1237 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 LLLLVAFAKHAAAATTIATNPEATTTTVSNYTVTTTALSSSTTTTSSG----SAPALSSAADKFA 125
            |||.:..|:....|...:.:|:...             .|....|..|    ..|..:||:|..|
Human     8 LLLCLLLAQLGLGAVGASRDPQGRP-------------DSPRERTPKGKPHAQQPGRASASDSSA 59

  Fly   126 GNWANLED--------------SFRNIVRIGDGNTVTRTSIE------------QSLVTIHDIAT 164
             .|:...|              ...:.:..||.:.:.|.:..            .:|.:.|....
Human    60 -PWSRSTDGTILAQKLAEEVPMDVASYLYTGDSHQLKRANCSGRYELAGLPGKWPALASAHPSLH 123

  Fly   165 ENLGTLCISTLYRPLQVPINSERYESSRQKTD----LAASILQEVGIIRHGGL---SDALA---- 218
            ..|.||..:|.:..:.:..|..|.::.:...|    |..|:|:....|....:   :|:|:
Human   124 RALDTLTHATNFLNVMLQSNKSREQNLQDDLDWYQALVWSLLEGEPSISRAAITFSTDSLSAPAP 188

  Fly   219 ----------KGLLTDDFITGARILALNLTNGAVQSYVWWVKGTAAEIQRY-DEDGLQIGKKPAG 272
                      ..:|..|..:.|.    :|.|..:::.  |..|...:.:.: ...|...|.:..|
Human   189 QVFLQATREESRILLQDLSSSAP----HLANATLETE--WFHGLRRKWRPHLHRRGPNQGPRGLG 247

  Fly   273 SYPWFDDETSSPTLRSPKFAPSPPNNYYKGWWTYPYFSCSQSR----WLVSYSIAIPPIGRHGL- 332
             :.|           ..|.......:::|  |:.||..|....    |||:.|.||     :||
Human   248 -HSW-----------RRKDGLGGDKSHFK--WSPPYLECENGSYKPGWLVTLSSAI-----YGLQ 293

  Fly   333 -------RGFISIDIDVSTLRVNQCEAEPYPFGSRRQKMQQLQTHNRLGARRSLFLGSRMGAIDE 390
                   ||.:.:||::..:.::||.::.:
Human   294 PNLVPEFRGVMKVDINLQKVDIDQCSSDGW----------------------------------- 323

  Fly   391 STINDLQAFHSSHKCHRTSMVCDYRQPSAETPTVTGGKLLTTLTGSSSWTRGSYQCLCRGGFY-- 453
                    |..:||||..:..|        .|....|.:|           |:|:|:|:.|||
Human   324 --------FSGTHKCHLNNSEC--------MPIKGLGFVL-----------GAYECICKAGFYHP 361

  Fly   454 --------SLRHPD-GFNGTIMEIAWQEQQDNISNYYSEVFKCLPCAPGCDTCTGPEPCLANYHW 509
                    ..|.|| ..:|:..:::            .|.:.||||..||..|....||......
Human   362 GVLPVNNFRRRGPDQHISGSTKDVS------------EEAYVCLPCREGCPFCADDSPCFVQEDK 414

  Fly   510 PFRISLLTISIGCACGTFVLAGYLFRHRRVKVFKVASPIFLMITLIGCAIMYLEMVAIFPYLDTT 574
            ..|:::::....|....||....::..|:.|..:.:..|.|...|.|..::|..:|.::....|.
Human   415 YLRLAIISFQALCMLLDFVSMLVVYHFRKAKSIRASGLILLETILFGSLLLYFPVVILYFEPSTF 479

  Fly   575 WCIATKWTRHMGFCITYTSLLMKTWRVSLTYRVKSAHKIK-LNDQQLLQWMVPILLVMLIYLGTW 638
            .||..:|.|.:||...|.::.:|..||...:..::|.:|. :...::::.:..||||:..:|..|
Human   480 RCILLRWARLLGFATVYGTVTLKLHRVLKVFLSRTAQRIPYMTGGRVMRMLAVILLVVFWFLIGW 544

  Fly   639 TISATPTAE---VILDQSQ----LKFKQCSYNWWDHSLAIGEVFFLAWGIRVCYNVRNAESLYNE 696
            |.|.....|   .::.|.:    |.|..|..:.||:..|:.|..||.||:.:||.||...|.::|
Human   545 TSSVCQNLEKQISLIGQGKTSDHLIFNMCLIDRWDYMTAVAEFLFLLWGVYLCYAVRTVPSAFHE 609

  Fly   697 ARLISYAIYNIALVNIAMVVFHVMLFPNAG---PDYKYMLGFVRTQLSTTTTIALVFGPKILR-- 756
            .|.::.|::|..:::   .:||.:.|..|.   .|:..||.|..|.|:.|.||.|:..||...
Human   610 PRYMAVAVHNELIIS---AIFHTIRFVLASRLQSDWMLMLYFAHTHLTVTVTIGLLLIPKFSHSS 671

  Fly   757 -------VFKGQGDKWDQ-------KAKVRSITASFSLNGVGLVPEESPDLYQENEELKEQVQKL 807
                   ..:...|:.|.       .:.:.|..:..||               :.|:::::::||
Human   672 NNPRDDIATEAYEDELDMGRSGSYLNSSINSAWSEHSL---------------DPEDIRDELKKL 721

  Fly   808 AHQIEFMKTVHMQMNNRHLK----PKPGGYFTITSTSFQAPYSKNTVSTAQTQTGKDE------- 861
            ..|:|..|...|..||.||:    .|.|...:|.....:.|.:.:...:.:.:.|.|.
Human   722 YAQLEIYKRKKMITNNPHLQKKRCSKKGLGRSIMRRITEIPETVSRQCSKEDKEGADHGTAKGTA 786

  Fly   862 -----------NSTPTKLKSPKGKVXRGQRS------VKDCSIEIDG----GQGRTTLVEDAIEF 905
                       |:..:|.::.|.:|...::|      |:|.:.|...    .|...|.....:|.
Human   787 LIRKNPPESSGNTGKSKEETLKNRVFSLKKSHSTYDHVRDQTEESSSLPTESQEEETTENSTLES 851

  Fly   906 NFHLADTEKGLIVQEDERPGSDEEEAALIAQFRRLFAPILDDSLNLYYQLNDLDDTEHVRIHQTV 970
            ......|:|   ::||....|.|.            .|::..|.:. :.|:....|.|.|.....
Human   852 LSGKKLTQK---LKEDSEAESTES------------VPLVCKSASA-HNLSSEKKTGHPRTSMLQ 900

  Fly   971 AQMNDLTSSEEETM----VTQ-------VNSPSPPPVGVELLLPISSDSST-----ASSSLYAIH 1019
            ..::.:.|::|:|:    .||       ..|..|.|...|.....|:..:|     |..:.....
Human   901 KSLSVIASAKEKTLGLAGKTQTAGVEERTKSQKPLPKDKETNRNHSNSDNTETKDPAPQNSNPAE 965

  Fly  1020 TPSPAHPSGVLLMPQNLESPLLSGSDAITITEQV---------------ELHNPP--------HH 1061
            .|.....||:  |.|...:|..:.||....|.|:               :|...|        .|
Human   966 EPRKPQKSGI--MKQQRVNPTTANSDLNPGTTQMKDNFDIGEVCPWEVYDLTPGPVPSESKVQKH 1028

  Fly  1062 LQLL--EDENNTSCSL----------------------------------SSNLTDSKTLDGRTP 1090
            :.::  |.|.|.:.||                                  .|.|.|.|.|..:||
Human  1029 VSIVASEMEKNPTFSLKEKSHHKPKAAEVCQQSNQKRIDKAEVCLWESQGQSILEDEKLLISKTP 1093

  Fly  1091 IV 1092
            ::
Human  1094 VL 1095

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31760	NP_723730.2	FU	486..>508	CDD:214589	9/21 (43%)
CG31760	NP_723730.2	7tm_3	526..754	CDD:278433	68/238 (29%)
GPR158	NP_065803.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..66		10/56 (18%)
		7tm_3	428..667	CDD:278433	68/241 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	757..999		48/259 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1117..1164
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8475
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR32546
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910