DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31760 and gpr158a

DIOPT Version :9

Sequence 1:	NP_723730.2	Gene:	CG31760 / 34642	FlyBaseID:	FBgn0051760	Length:	1093	Species:	Drosophila melanogaster
Sequence 2:	XP_005162591.1	Gene:	gpr158a / 570001	ZFINID:	ZDB-GENE-060130-18	Length:	1364	Species:	Danio rerio

Alignment Length:	914	Identity:	201/914 - (21%)
Similarity:	342/914 - (37%)	Gaps:	241/914 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   304 WTYPYFSCSQS----RWLVSYSIAIPPIGRHGL--------RGFISIDIDVSTLRVNQCEAEPYP 356
            |:.||..|...    |||::.|     .|.:||        ||.:.:|:.:..:.::||.|:.:
Zfish   247 WSAPYLECENGNFIPRWLLTLS-----AGFYGLKPNRNPDFRGVVRVDVSLQDVDIDQCSADGW- 305

  Fly   357 FGSRRQKMQQLQTHNRLGARRSLFLGSRMGAIDESTINDLQAFHSSHKCHRTSMVCDYRQPSAET 421
                                                      |..:|:|:.|:|.|        .
Zfish   306 ------------------------------------------FAGTHRCNITTMEC--------L 320

  Fly   422 PTVTGGKLLTTLTGSSSWTRGSYQCLCRGGFYSLRHP-----DGF------NGTIMEIAWQEQQD 475
            |....|.:|           ..|:|.|:.|:|   ||     :||      .|| ..::......
Zfish   321 PVPGHGFVL-----------DKYKCHCKSGYY---HPSRVAVNGFKRKAGGKGT-EGLSHNRDVP 370

  Fly   476 NISNYYSEVFKCLPCAPGCDTCTGPEPCLANYHWPFRISLLTISIGCACGTFVLAGYLFRHRRVK 540
            ..|::      ||||..||..|....||:|......|:::|:....|....|:....|:..||.|
Zfish   371 ETSSH------CLPCQEGCSFCKDDTPCVARGDGALRMAVLSFQGLCMLVDFISMVLLYHFRRNK 429

  Fly   541 VFKVASPIFLMITLIGCAIMYLEMVAIFPYLDTTWCIATKWTRHMGFCITYTSLLMKTWRVSLTY 605
            ..:.:..|.|...|.|..::|..:|.::.......||..:|.|.:||...|.::.:|.:||...:
Zfish   430 SIRASGLILLEAILFGALLLYFPVVILYFQPSVFRCILLRWVRLLGFATVYGTVTLKLYRVLKVF 494

  Fly   606 RVKSAHKIK-LNDQQLLQWMVPILLVMLIYLGTWT--ISATPTAEVIL-----DQSQLKFKQCSY 662
            ..::|.:|. :...::|:.:..|||::|.:...||  :...|...:.|     ....|:|..|..
Zfish   495 LSRTAQRIPYMTSWRVLRLLCIILLIVLWFAIAWTSAVCQNPNRHLALISVGFTTDGLQFSMCLL 559

  Fly   663 NWWDHSLAIGEVFFLAWGIRVCYNVRNAESLYNEARLISYAIYNIALVNIAMVVFHVMLF---PN 724
            :.||:.:|:.|..||.||:.:|:.||...|.|:|.|.::.|::|..:::   .:||::.|   |.
Zfish   560 DRWDYMIAVAEFLFLLWGVYLCFAVRTVPSAYHEPRYMAIAVHNELILS---AIFHILRFTLAPE 621

  Fly   725 AGPDYKYMLGFVRTQLSTTTTIALVFGPKILRVFKGQGDKWDQKAKV---------------RSI 774
            ..||:..||.|..|.|:.|.|:.|:..||.|  |.|...:.|...:.               .||
Zfish   622 LHPDWMLMLFFAHTHLTVTVTLGLLLVPKFL--FAGTHLRDDIATEAYEDELDMGRSGSYLNSSI 684

  Fly   775 TASF--------------------SLNGVGLVPEESPDLYQENEELKEQVQKLAHQIEFMKTVHM 819
            |:::                    |:||.|:...:|....:.|||||    ||..|:|..|...|
Zfish   685 TSAWSEHSLDPEDIRTPEEMGQLSSINGCGVRSCDSLWEKRTNEELK----KLYSQLEIYKRKKM 745

  Fly   820 QMNNRHLK----PKPGGYFTITSTSFQAPYSKNTVSTA----QTQTGKDENS------------- 863
            ..||.||:    .|.|...::.....:.|.:.....:.    |.:.|.:.||
Zfish   746 LANNPHLQKKRSSKKGLGRSLMRRITEIPETMGRQCSRDDKDQGEHGSNHNSICVLRKNPFDPSH 810

  Fly   864 --TPTKLKSPKGKVXRGQRSVKDCSIEIDGGQGRTTLVEDAIEFNFHLADTE---------KGLI 917
              .|.|.:|.|.|| ..::|........|..:..::...|.:|    :..||         |.|:
Zfish   811 SVKPAKDESLKSKVFSLKKSHSSYDHVRDHSEDSSSSATDKME----VTTTEGSLLETLMGKKLV 871

  Fly   918 VQEDER--PGSDEEEAALIAQFRRLFAPILDDSLNLYYQLNDLDDTEHVRIHQTVAQMNDLTSSE 980
            .:..|:  ..|:..|:          .|::..|.:.:....|.... |.|.......::.:.|::
Zfish   872 KKSSEKIDVASESTES----------VPLVCKSASAHNLTADKKPI-HPRTSMLQKSLSVIASAK 925

  Fly   981 EETM---------------VTQVNSPSPPPVGVELLLPISSDSSTASSSLYAIHTPSPAHPSGVL 1030
            |:|:               ..|.||........|     ..:.........::.....|..:|:
Zfish   926 EKTLGLTGKAQGVEDSTKKANQKNSEGKTSAEAE-----EKEGYPKMIVSQSVEYKQTAAKTGI- 984

  Fly  1031 LMPQ------NLESPLLSGSDAITITE----QVE-LHNPPH-----HLQLLEDENNTSCSLSSNL 1079
            :.||      ::.|....|.|...::|    :|| |..|..     |:.:..::.||....||..
Zfish   985 MKPQMSGSQPSICSETAKGKDLCDLSEVCPWEVEDLPTPSENKVQKHVSIAPEQTNTVRGGSSKT 1049

  Fly  1080 TDSK 1083
            |.|:
Zfish  1050 TKSQ 1053

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31760	NP_723730.2	FU	486..>508	CDD:214589	10/21 (48%)
CG31760	NP_723730.2	7tm_3	526..754	CDD:278433	67/238 (28%)
gpr158a	XP_005162591.1	7tm_3	412..651	CDD:278433	67/241 (28%)
gpr158a	XP_005162591.1	Neuromodulin	1135..1276	CDD:284117
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	138	1.000	Domainoid score	I4786
eggNOG	1	0.900	-	-		E1_KOG4418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR32546
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910