DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31760 and GPR179

DIOPT Version :9

Sequence 1:	NP_723730.2	Gene:	CG31760 / 34642	FlyBaseID:	FBgn0051760	Length:	1093	Species:	Drosophila melanogaster
Sequence 2:	NP_001004334.3	Gene:	GPR179 / 440435	HGNCID:	31371	Length:	2367	Species:	Homo sapiens

Alignment Length:	1064	Identity:	217/1064 - (20%)
Similarity:	360/1064 - (33%)	Gaps:	333/1064 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 GSAPALSSAADKF--AGNWANLEDSFRNIVRIGDGNTVTRTSIEQSL----VTIHDIATENLGTL 170
            |..|:|..||...  |.|:.|:         :...|.:..:|:|:.:    ..:..:|..:....
Human    90 GLPPSLQGAAGTLAQAANFLNM---------LLQANDIRESSVEEDVEWYQALVRSVAEGDPRVY 145

  Fly   171 CISTLYRP------LQVPINSERYESSRQKTDLAASILQEVGIIRHGGL-SDALAKGLLTDDFIT 228
            .....:.|      ||:.:.:.|........||:.:.:||..  ..|.| :.||.|.:||:|.
Human   146 RALLTFNPPPGASHLQLALQATRTGEETILQDLSGNWVQEEN--PPGDLDTPALKKRVLTNDL-- 206

  Fly   229 GARILALNLTNGAVQSYVWWVKGTAAEIQRYDEDGLQIGKKPAGSYPWFDDETSSPTLRSPKFAP 293
                       |::.|..|      .:...|..|..|:...|
Human   207 -----------GSLGSPKW------PQADGYVGDTQQVRLSP----------------------- 231

  Fly   294 SPPNNYYKGWWTYPYFSCSQSR----WLVSYSIAIPPIGRHGL--------RGFISIDIDVSTLR 346
                         |:..|.:.|    ||::.|...     :||        ||.:.:|:|:.::.
Human   232 -------------PFLECQEGRLRPGWLITLSATF-----YGLKPDLSPEVRGQVQMDVDLQSVD 278

  Fly   347 VNQCEAEPYPFGSRRQKMQQLQTHNRLGARRSLFLGSRMGAIDESTINDLQAFHSSHKCHRTSMV 411
            :|||.:.|                                          ..:.::|.|...|..
Human   279 INQCASGP------------------------------------------GWYSNTHLCDLNSTQ 301

  Fly   412 CDYRQPSAETPTVTGGKLLTTLTGSSSWTRGSYQCLCRGGFY-----------------SLRHPD 459
            |        .|..:.|.:|           |.|.|.||.|||                 ....|:
Human   302 C--------VPLESQGFVL-----------GRYLCRCRPGFYGASPSGGLEESDFQTTGQFGFPE 347

  Fly   460 GFNGTIMEIAWQEQQDNISNYYSEVFKCLPCAPGCDTCTGPEPCLANYHWPFRISLLTISIGCAC 524
            |.:|.:::                   ||||..||.:|....|||.......|.::|.....|..
Human   348 GRSGRLLQ-------------------CLPCPEGCTSCMDATPCLVEEAAVLRAAVLACQACCML 393

  Fly   525 GTFVLAGYLFRHRRVKVFKVASPIFLMITLIGCAIMYLEMVAIFPYLDTTWCIATKWTRHMGFCI 589
            ..|:.....:|.||.|....:..:.|...|.|..::|..:..::.......|||.:|.|.:||.|
Human   394 AIFLSMLVSYRCRRNKRIWASGVVLLETVLFGFLLLYFPVFILYFKPSVFRCIALRWVRLLGFAI 458

  Fly   590 TYTSLLMKTWRVSLTYRVKSAHK-IKLNDQQLLQWMVPILLVMLIYLGTWTISA----------- 642
            .|.::::|.:||...:..::|.: ..|:..:||:.:..:||.:|.:|..||:.|
Human   459 VYGTIILKLYRVLQLFLSRTAQRSALLSSGRLLRHLGLLLLPVLGFLAVWTVGALERGIQHAPLV 523

  Fly   643 ----TPTAEVILDQSQLKFKQCSYNWWDHSLAIGEVFFLAWGIRVCYNVRNAESLYNEARLISYA 703
                ||:..        .|..|.::.||:.:.:.|:..|.||..:||..|...|.::|.|.:..|
Human   524 IRGHTPSGR--------HFYLCHHDRWDYIMVVAELLLLCWGSFLCYATRAVLSAFHEPRYMGIA 580

  Fly   704 IYNIALVNIAMVVFHVMLFPNAGPDYKYMLGFVRTQLSTTTTIALVFGPKILRVFKGQGDKWDQK 768
            ::|..|::.|......:|.|:..||:..:|.|..|..:.|||:||:|.||.          |...
Human   581 LHNELLLSAAFHTARFVLVPSLHPDWTLLLFFFHTHSTVTTTLALIFIPKF----------WKLG 635

  Fly   769 AKVRSITASFSLNGVGLVPEESPDLYQENE------------------ELKEQVQKLAHQIEFMK 815
            |..|.       ..|..|.|:..||.....                  :::::::||..|:|..|
Human   636 APPRE-------EMVDEVCEDELDLQHSGSYLGSSIASAWSEHSLDPGDIRDELKKLYAQLEVHK 693

  Fly   816 TVHMQMNNRHLKPKPGGYFTITSTSFQAPYSKNTVSTAQTQTGKDENS--------------TPT 866
            |..|..||.||..|.|........||.. |..........|..:|..|              ..:
Human   694 TKEMAANNPHLPKKRGSSCQGLGRSFMR-YLAEFPEALARQHSRDSGSPGHGSLPGSSRRRLLSS 757

  Fly   867 KLKSPKG-KVXRGQRSVKDCSIEID------------GGQGRTTLVEDAIE----FNFHLADTEK 914
            .|:.|:| ......||..|...|.|            ..:...|...:::|    ..|..|....
Human   758 SLQEPEGTPALHKSRSTYDQRREQDPPLLDSLLRRKLAKKASRTESRESVEGPPALGFRSASAHN 822

  Fly   915 GLI-----------VQEDERPGSDEEEAALIAQFRRLFAPILDDSLNLYYQLNDLDDTEHVRIHQ 968
            ..:           :|:.....|..|:|.|:|.     ...|:::   |.|..:.::.:..:
Human   823 LTVGERLPRARPASLQKSLSVASSREKALLMAS-----QAYLEET---YRQAKEREERKKAK--- 876

  Fly   969 TVAQMNDLTSSEEETMVTQVNSPS----PPPVGVELLLPISSDSSTA-SSSLYAIHTPSPAHPSG 1028
                         ..|.:.|..||    ..|.|.    |:|:..|.| |||:.:.||....|...
Human   877 -------------AAMASLVRRPSARRLERPRGA----PLSAPPSPAKSSSVDSSHTSGRLHEEA 924

  Fly  1029 VLLMP-----QNLESPLLSGSDAI 1047
            ...:|     ..:.:|:|:.|..:
Human   925 RRRLPHPPIRHQVSTPILALSGGL 948

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31760	NP_723730.2	FU	486..>508	CDD:214589	10/21 (48%)
CG31760	NP_723730.2	7tm_3	526..754	CDD:278433	66/243 (27%)
GPR179	NP_001004334.3	EGF_CA	278..327	CDD:238011	19/109 (17%)
		7tm_3	392..632	CDD:278433	67/257 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	731..818		14/86 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	869..932		17/82 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1039..1083
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1098..1198
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1247..1431
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1537..1557
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1577..1672
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1723..1757
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1823..1852
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1886..2108
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2133..2212
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2308..2367
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8475
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR32546
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910