DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31760 and Gpr158

DIOPT Version :9

Sequence 1:	NP_723730.2	Gene:	CG31760 / 34642	FlyBaseID:	FBgn0051760	Length:	1093	Species:	Drosophila melanogaster
Sequence 2:	NP_001163797.1	Gene:	Gpr158 / 291352	RGDID:	1305841	Length:	1206	Species:	Rattus norvegicus

Alignment Length:	1073	Identity:	225/1073 - (20%)
Similarity:	389/1073 - (36%)	Gaps:	319/1073 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 SGSAPALSSAADKF--AGNWANL------------EDS---FRNIVR-IGDGNTVTRTSIEQSLV 157
            :.|.|:|..|.|..  |.|:.|:            :|.   ::.:|| :.:|    ..||.::.:
  Rat   116 ASSHPSLHGALDTLTHATNFLNMMLQSNKSREQTVQDDLQWYQALVRSLLEG----EPSISRAAI 176

  Fly   158 TIHDIATENLGTLCISTLYRPL-QVPINSERYESSRQKTDLAASILQEVGIIRHGGLSDALAKGL 221
            |   .:||:|.|        |. ||.:.:.|.||.....||::|
  Rat   177 T---FSTESLST--------PAPQVFLQATREESRILLQDLSSS--------------------- 209

  Fly   222 LTDDFITGARILALNLTNGAVQSYVWWVKGTAAEIQRY-DEDGLQIGKKPAGSYPWFDDETSSPT 285
                        |.:|.|..:::.  |..|...:.:.: ...|...|.:..| :.|
  Rat   210 ------------AHHLANATLETE--WFHGLRRKWRPHLHRRGSNQGPRGLG-HSW--------- 250

  Fly   286 LRSPKFAPSPPNNYYKGWWTYPYFSCSQSR----WLVSYSIAIPPIGRHGL--------RGFISI 338
              ..:.......::.|  |:.|:..|....    |||:.|.|.     :||        ||.:.:
  Rat   251 --RRRDGLGGDRSHVK--WSPPFLECENGSYKPGWLVTLSAAF-----YGLQPNLVPEFRGVMKV 306

  Fly   339 DIDVSTLRVNQCEAEPYPFGSRRQKMQQLQTHNRLGARRSLFLGSRMGAIDESTINDLQAFHSSH 403
            ||::..:.::||.::.:                                           |..:|
  Rat   307 DINLQKVDIDQCSSDGW-------------------------------------------FSGTH 328

  Fly   404 KCHRTSMVCDYRQPSAETPTVTGGKLLTTLTGSSSWTRGSYQCLCRGGFY----------SLRHP 458
            |||..:..|        .|....|.:|           |:|||:|:.|||          ..|.|
  Rat   329 KCHLNNSEC--------MPIKGLGFVL-----------GAYQCVCKAGFYHPRVFSVNNFQRRGP 374

  Fly   459 D-GFNGTIMEIAWQEQQDNISNYYSEVFKCLPCAPGCDTCTGPEPCLANYHWPFRISLLTISIGC 522
            | .|:|:..:::            .|...||||..||..|....||........|:::::....|
  Rat   375 DHHFSGSTKDVS------------EEAHVCLPCREGCPFCADDRPCFVQEDKYLRLAIISFQALC 427

  Fly   523 ACGTFVLAGYLFRHRRVKVFKVASPIFLMITLIGCAIMYLEMVAIFPYLDTTWCIATKWTRHMGF 587
            ....||....::..|:.|..:.:..|.|...|.|..::|..:|.::....|..||..:|.|.:||
  Rat   428 MLLDFVSMLVVYHFRKAKSIRASGLILLETILFGSLLLYFPVVILYFEPSTFRCILLRWVRLLGF 492

  Fly   588 CITYTSLLMKTWRVSLTYRVKSAHKIK-LNDQQLLQWMVPILLVMLIYLGTWTISATPTAE---V 648
            ...|.::.:|..||...:..::|.:|. :...::::.:..|:||:..:|..||.|.....|   :
  Rat   493 ATVYGTVTLKLHRVLKVFLSRTAQRIPYMTGGRVMRMLAVIVLVVFWFLVGWTSSMCQNLERDIL 557

  Fly   649 ILDQSQ----LKFKQCSYNWWDHSLAIGEVFFLAWGIRVCYNVRNAESLYNEARLISYAIYNIAL 709
            ::.|.|    |.|..|..:.||:..|:.|..||.|||.:||.||...|.::|.|.::.|::|..:
  Rat   558 LVGQGQTSDNLTFNMCLIDRWDYMTAVAEFLFLLWGIYLCYAVRTVPSAFHEPRYMAVAVHNELI 622

  Fly   710 VNIAMVVFHVMLFPNAG---PDYKYMLGFVRTQLSTTTTIALVFGPKILR---------VFKGQG 762
            :.   .:||.:.|..|.   ||:..||.|..|.|:.|.||.|:..||...         ..:...
  Rat   623 IT---AIFHTIRFVLASRLQPDWMLMLYFAHTHLTVTVTIGLLLIPKFSHSSNNPRDDIATEAYE 684

  Fly   763 DKWDQ-------KAKVRSITASFSLNGVGLVPEESPDLYQENEELKEQVQKLAHQIEFMKTVHMQ 820
            |:.|.       .:.:.|..:..||               :.|:::::::||..|:|..|...|.
  Rat   685 DELDMGRSGSYLNSSINSAWSEHSL---------------DPEDIRDELKKLYAQLEIYKRKKMI 734

  Fly   821 MNNRHLK----PKPGGYFTITSTSFQAPYSKNTVSTAQTQTGKDENSTPTKLKSPKGKVXRGQRS 881
            .||.||:    .|.|...:|.....:.|.:.:...:.:.:.|.|.::            .:|...
  Rat   735 TNNPHLQKKRCSKKGLGRSIMRRITEIPETVSRQCSKEDKEGTDHSA------------AKGTGL 787

  Fly   882 VKDCSIEIDGGQGRTTLVEDAIE---FNF--------HLADTEKGLIVQEDERPG----SDEEEA 931
            |:....|..|..||..  |::::   |:.        |:.|       |.||...    |.|||.
  Rat   788 VRKNPTESSGNTGRPK--EESLKNRVFSLKKSHSTYDHVRD-------QTDESSSLPTESQEEEV 843

  Fly   932 ALIAQF-----RRLFAPILDDSLNLYYQLNDLDDTE---------------------HVRIHQTV 970
            ...:..     ::|...:.:||        :.:.||                     |.|.....
  Rat   844 TENSTLESLSSKKLTQKVKEDS--------EAESTESVPLVCKSASAHNLSSEKKPGHPRTSMLQ 900

  Fly   971 AQMNDLTSSEEET-----------MVTQVNSPSPPPVGVELLLPISSDSSTA---SSSLYAIHTP 1021
            ..::.:.|::|:|           |..:..|..|.|...|.....|:..:|.   |....:.||.
  Rat   901 KSLSVIASAKEKTLGLAGKTQTLVMEDRAKSQKPQPKDRETNRKYSNSDNTETKDSGCPNSNHTE 965

  Fly  1022 SPAHPSGVLLMPQNLESPLLSGSDAITITEQVE 1054
            ....|....:|.|...:...:..||.:.|.|::
  Rat   966 ELRKPQKSGIMKQQRVNLPTANPDASSSTTQIK 998

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31760	NP_723730.2	FU	486..>508	CDD:214589	9/21 (43%)
CG31760	NP_723730.2	7tm_3	526..754	CDD:278433	70/238 (29%)
Gpr158	NP_001163797.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..62
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	234..253		4/30 (13%)
		7tmC_GPR158-like	415..672	CDD:320420	73/259 (28%)
		TM helix 1	416..440	CDD:320420	4/23 (17%)
		TM helix 2	452..473	CDD:320420	6/20 (30%)
		TM helix 3	482..504	CDD:320420	7/21 (33%)
		TM helix 4	528..544	CDD:320420	4/15 (27%)
		TM helix 5	575..598	CDD:320420	9/22 (41%)
		TM helix 6	610..632	CDD:320420	5/24 (21%)
		TM helix 7	641..666	CDD:320420	10/24 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	757..899		27/170 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1136..1166
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	135	1.000	Domainoid score	I4838
eggNOG	1	0.900	-	-		E1_KOG4418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR32546
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910