DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31760 and Gpr179

DIOPT Version :9

Sequence 1:	NP_723730.2	Gene:	CG31760 / 34642	FlyBaseID:	FBgn0051760	Length:	1093	Species:	Drosophila melanogaster
Sequence 2:	NP_001074689.1	Gene:	Gpr179 / 217143	MGIID:	2443409	Length:	2293	Species:	Mus musculus

Alignment Length:	1098	Identity:	224/1098 - (20%)
Similarity:	374/1098 - (34%)	Gaps:	360/1098 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 SGSAPALSSAADKF--AGNWANLEDSFRNIVRIGDGNTVTRTSIEQSL----VTIHDIATENLGT 169
            :|..|.|..||...  |.|:.|:         :...|.:..:|:|:.:    ..:..:|..:...
Mouse    89 AGVPPVLQRAAGTLAQAANFLNM---------LLQANDIRESSVEEDVEWYQALVRSVAEGDPKA 144

  Fly   170 LCISTLYRP------LQVPINSERYESSRQKTDLAASILQEVGIIRHGGLSD--ALAKGLLTDDF 226
            ......:.|      ||:.:.:.|........||:.:.:||.   ..|...|  .|.|.:||:|
Mouse   145 YRALLTFNPAPGASHLQLALQATRMGDETVLQDLSGNKVQEE---TPGEDLDRPVLQKRVLTND- 205

  Fly   227 ITGARILALNLTNGAVQSYVWWVKGTAAEIQRYDEDGLQIGKKPAGSYPWFDDETSSPTLRSPKF 291
                 :.:|:...        |.:|          || .:|                 .::..|.
Mouse   206 -----LRSLDSPK--------WPRG----------DG-YVG-----------------DIQQVKL 229

  Fly   292 APSPPNNYYKGWWTYPYFSCSQSR----WLVSYSIAIPPIGRHGL--------RGFISIDIDVST 344
            :|             |:..|.:.:    |||:.|...     :||        ||.:.:|||:.:
Mouse   230 SP-------------PFLECHEGQLRPGWLVTVSATF-----YGLKPDLTPEVRGQVQMDIDLQS 276

  Fly   345 LRVNQCEAEPYPFGSRRQKMQQLQTHNRLGARRSLFLGSRMGAIDESTINDLQAFHSSHKCHRTS 409
            :.:|||.:.|                                          ..:.::|.|...|
Mouse   277 VDINQCASGP------------------------------------------GWYSNTHLCDLNS 299

  Fly   410 MVCDYRQPSAETPTVTGGKLLTTLTGSSSWTRGSYQCLCRGGFYSLRHPDGFNGTIMEIAWQ--E 472
            ..|        .|..:.|.:|           |.|.|.||.|||......|...:..:.|.|  .
Mouse   300 TQC--------VPLESQGFVL-----------GRYLCRCRPGFYGASGSGGLEESATQAAGQFGS 345

  Fly   473 QQDNISNYYSEVFKCLPCAPGCDTCTGPEPCLANYHWPFRISLLTISIGCACGTFVLAGYLFRHR 537
            .||::    .::.:|.||..||.:|....|||.......|.::|.....|....|:.....:|.|
Mouse   346 PQDSL----GKLLRCQPCPEGCTSCLDATPCLVEEALALRTAVLACQACCMLAVFLSMLVAYRCR 406

  Fly   538 RVKVFKVASPIFLMITLIGCAIMYLEMVAIFPYLDTTWCIATKWTRHMGFCITYTSLLMKTWRVS 602
            ..|..:.:..:.|...|.|..::|..:..::.......|:|.:|.|.:||.:.|.::::|.:||.
Mouse   407 GSKRIRASGIVLLETILFGSLLLYFPVFILYFKPSVFRCVALRWVRLLGFAVVYGTIILKLYRVL 471

  Fly   603 LTYRVKSAHKI-KLNDQQLLQWMVPILLVMLIYLGTWTISA---------------TPTAEVILD 651
            ..:..::|.:: ..:..|||:.:..:||::|.:|..||..|               |||..
Mouse   472 QLFLSRTAQRVPHPSSGQLLRRLGQLLLLVLGFLVVWTAGALEPGTQHTALVTRGHTPTGR---- 532

  Fly   652 QSQLKFKQCSYNWWDHSLAIGEVFFLAWGIRVCYNVRNAESLYNEARLISYAIYNIALVNIAMVV 716
                .|..|.::.||:.:.:.|:..|.||..:||..|...|.::|.|.:|.|::|..|::.|...
Mouse   533 ----HFYLCHHDHWDYIMVVAEMLLLCWGSFLCYATRAVPSAFHEPRYMSIALHNELLLSTAFHT 593

  Fly   717 FHVMLFPNAGPDYKYMLGFVRTQLSTTTTIALVFGPKILRVFKGQGDKWDQKAKVRSITASFSLN 781
            ...:|.|:..||:..:|.|:.|..:.|.|:||:|.||.          |...|..|.       .
Mouse   594 ARFVLVPSLHPDWTLLLFFLHTHSTVTATLALIFIPKF----------WKPGAPPRE-------E 641

  Fly   782 GVGLVPEESPDLYQ------------------ENEELKEQVQKLAHQIEFMKTVHMQMNNRHLKP 828
            .:..|.|:..||.:                  |..:::::::||..|:|..||..|..||.||..
Mouse   642 ILDEVYEDELDLQRSGSYLNSSIASAWSERSLEPGDIRDELKKLYAQLEIRKTKEMAANNPHLPK 706

  Fly   829 KPGGYFTITSTSFQAPYSKNTVSTAQTQTGKDENS---------------TPTKLKSPKGKVXRG 878
            |.|........||.. |..........|..:|..|               :.:..::.|... |.
Mouse   707 KRGSSHQGLGRSFMR-YLAEFPEALARQHSRDSGSLGLGSLPGSSRRRLLSSSLQETEKPPALRK 770

  Fly   879 QRSVKD-----------------CSIEIDGGQGRTTLVEDAIEFNFHLADT-------------- 912
            .||..|                 .|.:.....||.:|.:......|..|..
Mouse   771 TRSTYDHHREHNTLPFDSTLRRTLSKKASPTDGRESLADGPPALGFRSASAHNLTVGERLPRARP 835

  Fly   913 --------------EKGLIV-----------QEDERPGSDEEEAALIAQFRR---------LFAP 943
                          ||.|:|           |..||....:.|||:::..||         |.||
Mouse   836 ISLQKSLSVAAGSREKALLVASQAYLEETYRQAKEREERKKAEAAMVSPVRRPSTRRLEWPLRAP 900

  Fly   944 I-----------LDDSLNLYYQLNDLDDTEHVRIHQTVAQMNDLTSSEEETMVTQVNSPSP-PPV 996
            :           :|.|                   ||.|:.::           :.....| ||:
Mouse   901 LSAPPSPGKSSSMDSS-------------------QTTARPHE-----------EAGRRLPHPPI 935

  Fly   997 GVELLLPISSDSS-----------TASSSLYAIHTPSPAHPSGVLLMPQNL--ESPLL 1041
            ..::..|:.:.|.           |.:|:|..|..|:||.....:|.|.:.  :||.|
Mouse   936 RHQVSTPVLALSGICLGEPRMLSPTPASTLAPILLPAPAPAPAPVLAPVSKPPQSPTL 993

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31760	NP_723730.2	FU	486..>508	CDD:214589	9/21 (43%)
CG31760	NP_723730.2	7tm_3	526..754	CDD:278433	64/243 (26%)
Gpr179	NP_001074689.1	EGF_CA	278..327	CDD:238011	19/109 (17%)
Gpr179	NP_001074689.1	7tm_3	392..632	CDD:278433	65/257 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	134	1.000	Domainoid score	I4981
eggNOG	1	0.900	-	-		E1_KOG4418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR32546
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910