DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31760 and gpr179

DIOPT Version :9

Sequence 1:	NP_723730.2	Gene:	CG31760 / 34642	FlyBaseID:	FBgn0051760	Length:	1093	Species:	Drosophila melanogaster
Sequence 2:	XP_031750226.1	Gene:	gpr179 / 100496332	XenbaseID:	XB-GENE-994077	Length:	1546	Species:	Xenopus tropicalis

Alignment Length:	934	Identity:	221/934 - (23%)
Similarity:	375/934 - (40%)	Gaps:	225/934 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 CQRQQQV----DTYTW---------------LTTQAVPLLWLHLLLLVAFAKHAAAATTIATNPE 86
            |...||:    :::.|               |:|.:..|........|:....:|.|.|.:::||
Frog    11 CHHAQQIVHANESFPWTTNAKEWMPAPTPTPLSTTSPGLPSTSFPSAVSSLAVSAPADTASSSPE 75

  Fly    87 AT-------TTTVSNYTVTTTALSSST-TTTSSGSAPALS--SAADKFAGNWANLEDSFRNIVRI 141
            :|       :|:.::::|||.|.|... .....||..||:  .:.|....:.||...||......
Frog    76 STSSLPFSPSTSSTSFSVTTLAPSPDVDKADEEGSKAALNFLHSGDHLLLSEANCSKSFELTDLQ 140

  Fly   142 GDGNTVTRTSI---EQSLVTIHDIATENLGTLCISTLYRPLQVPINSERYESSRQKTDLAASILQ 203
            |.......:.|   :.||  :|  ||..|..:..::..|...:..:.|.|.:      |..|:..
Frog   141 GPPPETLLSHIRGPQDSL--LH--ATNFLNMIFQASDMRESSIKEDMEWYHA------LVRSLAG 195

  Fly   204 EVGIIRHGGLSDALAKGLLTDDFITGARILALNLTNGAVQSYVWWVKGTAAEIQRYDEDGLQIGK 268
            ....||...||       ||...::...:|.|..|.          ||....:|....| ...|:
Frog   196 GQPNIRRALLS-------LTAHPMSSKPLLLLRATK----------KGHEILLQDLSSD-FYHGR 242

  Fly   269 KPAGSYPWFDDETSSP-----------TLRSPKFAPSPPNNYYKGW----WTYPYFSCSQSR--- 315
            .......|.:...||.           :|.:||:  |..::|....    |:.|:..|....
Frog   243 HKGNWGSWDNFHASSSLTKAILLNDLRSLDTPKW--SRGDSYIVDLSHVRWSKPFLECEGGHFLQ 305

  Fly   316 -WLVSYSIAIPPIGRHGL--------RGFISIDIDVSTLRVNQCEAEPYPFGSRRQKMQQLQTHN 371
             |::|.|.|.     :||        :|.:.:|:.:..|.::||...|
Frog   306 GWMISLSTAF-----YGLKPDLSPEFKGTLRVDVQLLNLGIDQCAKGP----------------- 348

  Fly   372 RLGARRSLFLGSRMGAIDESTINDLQAFHSSHKCHRTSMVC--DYRQPSAETPTVTGGKLLTTLT 434
                                     ..|.:||.|...|..|  |.:.          |.:|
Frog   349 -------------------------GWFANSHSCDENSTQCISDEKD----------GSIL---- 374

  Fly   435 GSSSWTRGSYQCLCRGGFYSLRHPDGFNGTIMEIAWQEQQDNISNYYSEVFKCLPCAPGCDTCTG 499
                   |.|:|:|:.|:|..||               :...|||     ..|.||:.||.||..
Frog   375 -------GRYRCVCQPGYYRTRH---------------EGSEISN-----VACRPCSEGCATCVD 412

  Fly   500 PEPCLANYHWPFRISLLTISIGCACGTF--VLAGYLFR-HRRVKVFKVASPIFLMIT-LIGCAIM 560
            ..|||.:..|..|:::|::........|  :|..|.|| .:|::    ||.:.|:.| |.|..::
Frog   413 GSPCLVDEDWALRVTVLSVQATGMLAVFLSMLVSYSFRDSKRIR----ASGLILLETILFGSLLL 473

  Fly   561 YLEMVAIFPYLDTTWCIATKWTRHMGFCITYTSLLMKTWRVSLTYRVKSAHKIK-LNDQQLLQWM 624
            |..:..::.......|:|.:|.|.:||||.|.::::|.:||...:..::|.::. |...:||:.:
Frog   474 YFPVFILYFKPSVFRCVALRWVRLLGFCIVYGTIVLKLYRVMKVFLSRTAQRVPYLTSMRLLRML 538

  Fly   625 VPILLVMLIYLGTWTISATPTAE-----VILDQSQ--LKFKQCSYNWWDHSLAIGEVFFLAWGIR 682
            ...||..:.:|..||:.|....:     ||..|::  |.|..|.::.||:.::|.||.||.||..
Frog   539 FVFLLFCIWFLVGWTVGALENLQRGVPVVIRTQTREGLVFYTCDHDRWDYMMSIAEVLFLCWGSF 603

  Fly   683 VCYNVRNAESLYNEARLISYAIYNIALVNIAMVVFHVMLFPNAGPDYKYMLGFVRTQLSTTTTIA 747
            :||..|:..|.::|.|.:..||:|..:|:.|..|...::.|:..||:..:|.|:.|..:.|.|:.
Frog   604 LCYGARSIPSAFHEPRYMGIAIHNEMIVSAAFHVLRFLIVPSLHPDWTLLLFFIHTHGTVTMTLT 668

  Fly   748 LVFGPKIL------------RVFKGQGDKWDQKAKVR-SITASFSLNGVGLVPEESPDLYQENEE 799
            |:|.||.|            .|::.:.|....::.:. |||:::|        |.|.|    .::
Frog   669 LLFIPKFLHAGVPPREEIATEVYEDELDMRRSRSNLNSSITSAWS--------EHSLD----PDD 721

  Fly   800 LKEQVQKLAHQIEFMKTVHMQMNNRHLKPK----PGGYFTITSTSFQAPYSKNTVSTAQTQTGKD 860
            ::::::||..|:|..||..|.:||.||:.|    .|...:|.....:.|.|.|..||.:.:.|..
Frog   722 IRDELKKLYAQLEVHKTKKMTINNPHLQKKRSSRRGLGRSIMRRITETPDSANRQSTREDKEGSP 786

  Fly   861 ENSTPTKLK-SPKGKVXRGQRSVK 883
            .:|...:.| ...|.|.:.:.|::
Frog   787 GSSGGQRRKQQDSGSVKQREESLR 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31760	NP_723730.2	FU	486..>508	CDD:214589	10/21 (48%)
CG31760	NP_723730.2	7tm_3	526..754	CDD:278433	73/239 (31%)
gpr179	XP_031750226.1	TM helix 4	536..552	CDD:320420	3/15 (20%)
		TM helix 5	583..606	CDD:320420	9/22 (41%)
		TM helix 6	618..640	CDD:320420	7/21 (33%)
		TM helix 7	649..674	CDD:320420	8/24 (33%)
		PTZ00214	<368..>415	CDD:173479	20/87 (23%)
		7tmC_GPR158-like	423..679	CDD:320420	77/259 (30%)
		TM helix 1	424..448	CDD:320420	4/23 (17%)
		TM helix 2	460..481	CDD:320420	5/20 (25%)
		TM helix 3	490..512	CDD:320420	9/21 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	140	1.000	Domainoid score	I4715
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR32546
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010