DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment rho-6 and RHBDL3

DIOPT Version :9

Sequence 1:	NP_788038.1	Gene:	rho-6 / 34640	FlyBaseID:	FBgn0032415	Length:	263	Species:	Drosophila melanogaster
Sequence 2:	NP_001350764.1	Gene:	RHBDL3 / 162494	HGNCID:	16502	Length:	428	Species:	Homo sapiens

Alignment Length:	258	Identity:	60/258 - (23%)
Similarity:	93/258 - (36%)	Gaps:	82/258 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 DDLTRTIDVGHVRRKRLWRV--------PWFILLMSFVQIS-------------LHWIASECMQK 95
            :.|.|.||       |.|..        |||::.::.::::             |.......::.
Human   142 ETLPREID-------RKWYYDSYTCCPPPWFMITVTLLEVAFFLYNGVSLGQFVLQVTHPRYLKN 199

  Fly    96 VLIFKPEWNVEYWRLLTYMLLHSDYWHLSLNICFQCFIGICLEVEQGHWRLAVVYMVGGVAG--- 157
            .|::.|:...:.||.|||:.:|:...||.||:..|..:|:.||:..|..|:.:||:.|.||.
Human   200 SLVYHPQLRAQVWRYLTYIFMHAGIEHLGLNVVLQLLVGVPLEMVHGATRIGLVYVAGVVAELVR 264

  Fly   158 -----SLANAWLQPHLHLMGASAGVYAMLGSHVPHLVLNFSQLSHRFARIASLLILLLSDVGFTT 217
                 ..|.....|:|:..|..||                        |:|.|..:.||.|  .:
Human   265 HEVPVQAAADGCGPYLYEHGVWAG------------------------RVAPLPPVGLSPV--PS 303

  Fly   218 YHFC---------HNHNRNPRTSLEAHIGGGVAGI-LCGFIVYRR----------LQPANQKA 260
            ...|         |:..|.....|.|...|.|..: .||.:...|          |.||..||
Human   304 PKLCGALGWRGRGHHPGRGGPEELRAEAPGPVTVVDFCGHVHRLRAVRCLLEHLCLHPAGLKA 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rho-6	NP_788038.1	Rhomboid	106..251	CDD:279958	42/162 (26%)
RHBDL3	NP_001350764.1	EF-hand_7	36..100	CDD:316058
		EF-hand motif	38..67	CDD:320054
		Rhomboid	205..>260	CDD:328780	20/54 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144495
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0705
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1253228at2759
OrthoFinder	1	1.000	-	-		FOG0000995
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45840
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.810