DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phae2 and ST14

DIOPT Version :9

Sequence 1:	NP_001285871.1	Gene:	Phae2 / 34638	FlyBaseID:	FBgn0263235	Length:	265	Species:	Drosophila melanogaster
Sequence 2:	NP_068813.1	Gene:	ST14 / 6768	HGNCID:	11344	Length:	855	Species:	Homo sapiens

Alignment Length:	293	Identity:	94/293 - (32%)
Similarity:	127/293 - (43%)	Gaps:	57/293 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LLAVCVSQGS--------------------GLALDQPEGRVVGGKAAAANSAPYIVSMQ-YGGTH 55
            |..:|:|:|:                    ||.....:.|||||..|.....|:.||:. .|..|
Human   575 LNGLCLSKGNPECDGKEDCSDGSDEKDCDCGLRSFTRQARVVGGTDADEGEWPWQVSLHALGQGH 639

  Fly    56 YCAANIINSNWLVTAAHCLANRNQVLGS-----TLVAG-----SIAVAGTASTTQKRQITHYVIN 110
            .|.|::|:.||||:||||..:......|     |...|     ..:..|......||.|:|...|
Human   640 ICGASLISPNWLVSAAHCYIDDRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFN 704

  Fly   111 DLYTGGTVPYDIGLIYTPTAFTWTAAVAPVKLP-SSGVRPTGKAD-LFGWGSTSKTNSPSYPKT- 172
            |.    |..|||.|:.......:::.|.|:.|| :|.|.|.|||. :.|||.|      .|..|
Human   705 DF----TFDYDIALLELEKPAEYSSMVRPICLPDASHVFPAGKAIWVTGWGHT------QYGGTG 759

  Fly   173 ---LQEAKNIPIISLDSCAAALGSKGQDVHTTNLCTGPLTGGTSFCTSDSGGPL----VQGNVL- 229
               ||:.: |.:|:..:|...|   .|.:....:|.|.|:||...|..||||||    ..|.:.
Human   760 ALILQKGE-IRVINQTTCENLL---PQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQ 820

  Fly   230 IGIVSWGKLPCGQPNSPSVYVQVSSFITWIAAN 262
            .|:||||. .|.|.|.|.||.::..|..||..|
Human   821 AGVVSWGD-GCAQRNKPGVYTRLPLFRDWIKEN 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phae2	NP_001285871.1	Tryp_SPc	31..259	CDD:214473	85/249 (34%)
Phae2	NP_001285871.1	Tryp_SPc	32..262	CDD:238113	86/251 (34%)
ST14	NP_068813.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		SEA	88..>171	CDD:307516
		CUB	227..332	CDD:238001
		CUB	340..444	CDD:238001
		LDLa	454..486	CDD:238060
		LDLa	488..523	CDD:238060
		LDLa	525..559	CDD:238060
		LDLa	567..602	CDD:238060	4/26 (15%)
		Tryp_SPc	615..852	CDD:238113	86/251 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433637at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920