DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phae2 and TMPRSS4

DIOPT Version :9

Sequence 1:	NP_001285871.1	Gene:	Phae2 / 34638	FlyBaseID:	FBgn0263235	Length:	265	Species:	Drosophila melanogaster
Sequence 2:	XP_005271670.1	Gene:	TMPRSS4 / 56649	HGNCID:	11878	Length:	494	Species:	Homo sapiens

Alignment Length:	244	Identity:	82/244 - (33%)
Similarity:	122/244 - (50%)	Gaps:	17/244 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 GLALDQPEGRVVGGKAAAANSAPYIVSMQYGGTHYCAANIINSNWLVTAAHCLANRNQVLGSTLV 86
            |.:|..|  ||||.:.|:.:|.|:.||:||...|.|..:|::.:|::|||||......|....:.
Human   197 GKSLKTP--RVVGVEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVFNWKVR 259

  Fly    87 AGSIAVAGTASTTQKRQITHYVINDLYTGGTVPYDIGLIYTPTAFTWTAAVAPVKLP--SSGVRP 149
            |||..: |:..:....:|.....|.:|....   ||.|:......|::..|.|:.||  ...:.|
Human   260 AGSDKL-GSFPSLAVAKIIIIEFNPMYPKDN---DIALMKLQFPLTFSGTVRPICLPFFDEELTP 320

  Fly   150 TGKADLFGWGSTSKTNSPSYPKTLQEAKNIPIISLDSCAAALGSKGQDVHTTNLCTGPLTGGTSF 214
            .....:.|||.| |.|.......|.:| ::.:|....|.|....:| :|....:|.|...||...
Human   321 ATPLWIIGWGFT-KQNGGKMSDILLQA-SVQVIDSTRCNADDAYQG-EVTEKMMCAGIPEGGVDT 382

  Fly   215 CTSDSGGPLV----QGNVLIGIVSWGKLPCGQPNSPSVYVQVSSFITWI 259
            |..||||||:    |.:| :|||||| ..||.|::|.||.:||:::.||
Human   383 CQGDSGGPLMYQSDQWHV-VGIVSWG-YGCGGPSTPGVYTKVSAYLNWI 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phae2	NP_001285871.1	Tryp_SPc	31..259	CDD:214473	77/233 (33%)
Phae2	NP_001285871.1	Tryp_SPc	32..262	CDD:238113	78/234 (33%)
TMPRSS4	XP_005271670.1	LDLa	58..92	CDD:238060
		SRCR_2	108..197	CDD:295335	82/244 (34%)
		Tryp_SPc	204..429	CDD:214473	77/233 (33%)
		Tryp_SPc	205..432	CDD:238113	78/234 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147446
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840