Protein Alignment Phae2 and PLAT

DIOPT Version :10

• Sequence 1: NP_609551.2
• Gene: Phae2 / 34638
• FlyBaseID: FBgn0263235
• Length: 265
• Species: Drosophila melanogaster
• Sequence 2: NP_000921.1
• Gene: PLAT / 5327
• HGNCID: 9051
• Length: 562
• Species: Homo sapiens
• Alignment Length: 267
• Identity: 74/267 - (27%)
• Similarity: 117/267 - (43%)
• Gaps: 40/267 - (14%)

  Fly    27 QPEGRVVGGKAAAANSAPYIVSM------QYGGTHYCAANIINSNWLVTAAHCLANRNQVLGSTL 85
            ||:.|:.||..|...|.|:..::      ..|....|...:|:|.|:::||||...|......|:
Human   306 QPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHLTV 370

  Fly    86 VAGSIAVAGTASTTQKRQITHYVINDLYTGGTVPYDIGLIYTPTAFTWTA----AVAPVKLPSSG 146
            :.|...........||.::..|:::..:...|...||.|:...:..:..|    .|..|.||.:.
Human   371 ILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRTVCLPPAD 435

  Fly   147 VR--PTGKADLFGWGSTSKTNSPSYPKTLQEAKNIPIISLDSCAAALGSKGQDVHTTN------- 202
            ::  ...:.:|.|:|. .:..||.|.:.|:|| ::.:.....|.:.        |..|
Human   436 LQLPDWTECELSGYGK-HEALSPFYSERLKEA-HVRLYPSSRCTSQ--------HLLNRTVTDNM 490

  Fly   203 LCTGPLTGG------TSFCTSDSGGPLVQGN----VLIGIVSWGKLPCGQPNSPSVYVQVSSFIT 257
            ||.|....|      ...|..|||||||..|    .|:||:||| |.|||.:.|.||.:|::::.
Human   491 LCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWG-LGCGQKDVPGVYTKVTNYLD 554

  Fly   258 WIAANQK 264
            ||..|.:
Human   555 WIRDNMR 561

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Phae2	NP_609551.2	Tryp_SPc	32..262	CDD:238113	70/258 (27%)
PLAT	NP_000921.1	FN1	41..83	CDD:214494
		Important for binding to annexin A2	42..52
		EGF	86..117	CDD:394967
		KR	125..209	CDD:238056
		Kringle	215..296	CDD:395005
		Tryp_SPc	313..559	CDD:238113	70/256 (27%)