DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Phae2 and PRSS53

DIOPT Version :9

Sequence 1:	NP_001285871.1	Gene:	Phae2 / 34638	FlyBaseID:	FBgn0263235	Length:	265	Species:	Drosophila melanogaster
Sequence 2:	XP_011544118.1	Gene:	PRSS53 / 339105	HGNCID:	34407	Length:	623	Species:	Homo sapiens

Alignment Length:	330	Identity:	82/330 - (24%)
Similarity:	126/330 - (38%)	Gaps:	102/330 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ATILLLAV------CVSQGSGLALDQPEGRVVGGKAAAANSAPYIVSMQYGGTHYCAANIINSNW 66
            ||:|:..:      |..:|.|....| ||..|.|:      .|:..|::..|.|.|:.:::...|
Human    14 ATVLMEGLQAAQRACGQRGPGPPKPQ-EGNTVPGE------WPWQASVRRQGAHICSGSLVADTW 71

  Fly    67 LVTAAHC--------LANRNQVLGST----LVAGSIAVAGTASTTQKRQITHYVINDLYTGGTVP 119
            ::|||||        |.:.:.||||.    |..|:..| |.|:....|...|      |:.|:
Human    72 VLTAAHCFEKAAATELNSWSVVLGSLQREGLSPGAEEV-GVAALQLPRAYNH------YSQGS-- 127

  Fly   120 YDIGLIYT--PTAFTWTAAVAPVKLPSSGVR-PTGKAD-LFGWG--------------------- 159
             |:.|:..  ||..|      |:.||....| |.|.:. ..||.
Human   128 -DLALLQLAHPTTHT------PLCLPQPAHRFPFGASCWATGWDQDTSDGKCWPRLKLGEALCLP 185

  Fly   160 --STSKTNSPSY--------------------PKTLQEAKNIPIISLDSCAAALGSKGQDVHTTN 202
              :.|..|.|.:                    |.||:..: :.:||..:|........|. |.:|
Human   186 SVTVSAPNCPGFQSPLLPRSQTLAPAPSLSPAPGTLRNLR-LRLISRPTCNCIYNQLHQR-HLSN 248

  Fly   203 ------LCTGPLTGGTSFCTSDSGGPLV----QGN-VLIGIVSWGKLPCGQPNSPSVYVQVSSFI 256
                  ||.||..|....|..|||||::    .|: |..||:|:.. .|.|.::|.:....::..
Human   249 PARPGMLCGGPQPGVQGPCQGDSGGPVLCLEPDGHWVQAGIISFAS-SCAQEDAPVLLTNTAAHS 312

  Fly   257 TWIAA 261
            :|:.|
Human   313 SWLQA 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phae2	NP_001285871.1	Tryp_SPc	31..259	CDD:214473	71/297 (24%)
Phae2	NP_001285871.1	Tryp_SPc	32..262	CDD:238113	73/300 (24%)
PRSS53	XP_011544118.1	Tryp_SPc	42..316	CDD:238113	72/298 (24%)
		Tryp_SPc	43..314	CDD:214473	71/295 (24%)
		Tryp_SPc	359..>512	CDD:304450
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433637at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920