Protein Alignment Phae2 and KLK5

DIOPT Version :10

• Sequence 1: NP_609551.2
• Gene: Phae2 / 34638
• FlyBaseID: FBgn0263235
• Length: 265
• Species: Drosophila melanogaster
• Sequence 2: NP_036559.1
• Gene: KLK5 / 25818
• HGNCID: 6366
• Length: 293
• Species: Homo sapiens
• Alignment Length: 309
• Identity: 86/309 - (27%)
• Similarity: 123/309 - (39%)
• Gaps: 82/309 - (26%)

  Fly     1 MWRHRHLATILLLAV-----------C------VSQGSGLAL----------DQPEGRVVGGKAA 38
            ||....|.|.|||.|           |      |..||...|          |....|::.|...
Human     9 MWVLCALITALLLGVTEHVLANNDVSCDHPSNTVPSGSNQDLGAGAGEDARSDDSSSRIINGSDC 73

  Fly    39 AANSAPYIVSMQYGGTH-YCAANIINSNWLVTAAHCLANRNQVLGSTLVAGSIAVAGTASTTQKR 102
            ..::.|:..::...... ||.|.:::..||:|||||   |.:|.                   :.
Human    74 DMHTQPWQAALLLRPNQLYCGAVLVHPQWLLTAAHC---RKKVF-------------------RV 116

  Fly   103 QITHYVINDLYTGG--------TVPY----------DIGLIYTPTAFTWTAAVAPVKL----PSS 145
            ::.||.::.:|..|        ::|:          |:.||........|..|.|:.:    ||:
Human   117 RLGHYSLSPVYESGQQMFQGVKSIPHPGYSHPGHSNDLMLIKLNRRIRPTKDVRPINVSSHCPSA 181

  Fly   146 GVRPTGKADLFGWGSTSKTNSPSYPKTLQEAKNIPIISLDSCAAALGSKGQDVHTTNLCTGPLTG 210
            |.    |..:.||| |:|:....:||.|| ..||.::|...|..|.   .:.:..|..|.|...|
Human   182 GT----KCLVSGWG-TTKSPQVHFPKVLQ-CLNISVLSQKRCEDAY---PRQIDDTMFCAGDKAG 237

  Fly   211 GTSFCTSDSGGPLVQGNVLIGIVSWGKLPCGQPNSPSVYVQVSSFITWI 259
            ..| |..|||||:|....|.|:||||..||.:||.|.||..:..|..||
Human   238 RDS-CQGDSGGPVVCNGSLQGLVSWGDYPCARPNRPGVYTNLCKFTKWI 285

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Phae2	NP_609551.2	Tryp_SPc	32..262	CDD:238113	71/251 (28%)
KLK5	NP_036559.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	37..68		6/30 (20%)
		Tryp_SPc	66..285	CDD:214473	70/250 (28%)