DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phae2 and TMPRSS6

DIOPT Version :9

Sequence 1:	NP_001285871.1	Gene:	Phae2 / 34638	FlyBaseID:	FBgn0263235	Length:	265	Species:	Drosophila melanogaster
Sequence 2:	NP_001275929.1	Gene:	TMPRSS6 / 164656	HGNCID:	16517	Length:	824	Species:	Homo sapiens

Alignment Length:	271	Identity:	79/271 - (29%)
Similarity:	112/271 - (41%)	Gaps:	48/271 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 LDQPEGRVVGGKAAAANSAPYIVSMQYGGTHYCAANIINSNWLVTAAHCLANRNQVLGSTLV--- 86
            |..|..|:|||..::....|:..|:|..|.|.|...:|...|::|||||.  :...:.||::
Human   561 LQGPSSRIVGGAVSSEGEWPWQASLQVRGRHICGGALIADRWVITAAHCF--QEDSMASTVLWTV 623

  Fly    87 -AGSI----AVAGTASTTQKRQITH-YVINDLYTGGTVPYDIGLIYTPTAFTWTAAVAPVKLPS- 144
             .|.:    ...|..|....|.:.| |...|.:     .||:.|:........:|||.||.||:
Human   624 FLGKVWQNSRWPGEVSFKVSRLLLHPYHEEDSH-----DYDVALLQLDHPVVRSAAVRPVCLPAR 683

  Fly   145 --------------------SGVRPTGKADLFGW-GSTSKTNSPSYPKTLQEAKNIPIISLDSCA 188
                                ..:|....|..:|| ...|:|........||:. ::.:|..|.|:
Human   684 SHFFEPGLHCWITGWGALREGALRADAVALFYGWRNQGSETCCCPISNALQKV-DVQLIPQDLCS 747

  Fly   189 AALGSKGQDVHTTNLCTGPLTGGTSFCTSDSGGPLV----QGN-VLIGIVSWGKLPCGQPNSPSV 248
            ...   ...|....||.|...|....|..|||||||    .|. .|.|:|||| |.||:||...|
Human   748 EVY---RYQVTPRMLCAGYRKGKKDACQGDSGGPLVCKALSGRWFLAGLVSWG-LGCGRPNYFGV 808

  Fly   249 YVQVSSFITWI 259
            |.:::..|:||
Human   809 YTRITGVISWI 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phae2	NP_001285871.1	Tryp_SPc	31..259	CDD:214473	75/263 (29%)
Phae2	NP_001285871.1	Tryp_SPc	32..262	CDD:238113	76/264 (29%)
TMPRSS6	NP_001275929.1	SEA	77..177	CDD:307516
		CUB	326..440	CDD:238001
		LDLa	450..480	CDD:238060
		LDLa	486..516	CDD:238060
		Ldl_recept_a	520..557	CDD:278486
		Tryp_SPc	568..822	CDD:238113	76/264 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433637at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920