DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phae2 and tmprss6

DIOPT Version :9

Sequence 1:	NP_001285871.1	Gene:	Phae2 / 34638	FlyBaseID:	FBgn0263235	Length:	265	Species:	Drosophila melanogaster
Sequence 2:	XP_004913946.2	Gene:	tmprss6 / 100489045	XenbaseID:	XB-GENE-1011573	Length:	806	Species:	Xenopus tropicalis

Alignment Length:	257	Identity:	77/257 - (29%)
Similarity:	113/257 - (43%)	Gaps:	30/257 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 CVSQGSGLALDQPEGRVVGGKAAAANSAPYIVSMQYGGTHYCAANIINSNWLVTAAHCLANRNQV 80
            |..|..|:       |:|||..|.....|:..|:|..|.|.|...::...|::|||||....:..
Frog   562 CGIQAVGI-------RLVGGTQAQEGEWPWQASLQVRGEHICGGTLVADQWILTAAHCFTPESYA 619

  Fly    81 LGS--TLVAGSIAVAGTASTTQKR---QITHYVINDLYTGGTVPYDIGLIYTPTAFTWTAA-VAP 139
            ...  |:..|.:.:   :.:|||.   ::...||:..|...:..||:.|:........|:. |.|
Frog   620 SPEVWTVYLGKVRL---SRSTQKELAFKVIRLVIHPFYDEDSHDYDVALVLLDHLVPLTSPHVQP 681

  Fly   140 VKLPSSGVR-PTGKAD-LFGWGSTSKTNSPSYPKTLQEAKNIPIISLDSCAAALGSKGQDVHTTN 202
            :.||||... |||.:. :.||||. |.|.|: ...||:. :|.:::.|.|....   ...:....
Frog   682 ICLPSSTHHFPTGSSCWVTGWGSV-KENGPT-SDVLQKV-DIQLVAQDICTELY---RYQISPRM 740

  Fly   203 LCTGPLTGGTSFCTSDSGGPLV----QGN-VLIGIVSWGKLPCGQPNSPSVYVQVSSFITWI 259
            ||.|...|....|..|||.|||    .|. ...|:|||| ..||.|....||.:::..:.||
Frog   741 LCAGYRDGSKDACQGDSGSPLVCKTASGRWFQAGLVSWG-AGCGIPRYFGVYSRITRLVQWI 801

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phae2	NP_001285871.1	Tryp_SPc	31..259	CDD:214473	72/240 (30%)
Phae2	NP_001285871.1	Tryp_SPc	32..262	CDD:238113	73/241 (30%)
tmprss6	XP_004913946.2	SEA	77..176	CDD:396113
		CUB	235..303	CDD:412131
		LDLa	448..478	CDD:238060
		LDLa	480..514	CDD:238060
		LDLa	525..560	CDD:238060
		Tryp_SPc	572..804	CDD:238113	73/240 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433637at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920