DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phae1 and TMPRSS5

DIOPT Version :9

Sequence 1:	NP_001285870.1	Gene:	Phae1 / 34637	FlyBaseID:	FBgn0263234	Length:	270	Species:	Drosophila melanogaster
Sequence 2:	NP_110397.2	Gene:	TMPRSS5 / 80975	HGNCID:	14908	Length:	457	Species:	Homo sapiens

Alignment Length:	272	Identity:	87/272 - (31%)
Similarity:	124/272 - (45%)	Gaps:	14/272 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 QQTKSLASGLLLLLGICRISGVAIGAPEGRVVGGSPAAVNSAPYAVSMQYGGTHYCAASILNANW 70
            |...:..||.::.|   |.|.........|:|||...|....|:..|:..|..|.|..|:|...|
Human   191 QPRNNCTSGQVVSL---RCSECGARPLASRIVGGQSVAPGRWPWQASVALGFRHTCGGSVLAPRW 252

  Fly    71 LVTAAHCLTNSNQV-LGSTLVAGSIAVDGTASTTQTRSITYFVINDLYTGGTVPYDIGMIYTPTA 134
            :||||||:.:.... |.|..|...:.........|...:...:.:.||:.....||:.::...||
Human   253 VVTAAHCMHSFRLARLSSWRVHAGLVSHSAVRPHQGALVERIIPHPLYSAQNHDYDVALLRLQTA 317

  Fly   135 FVWSAAVAPVTLPSSGV-VPTGT-ANLYGWGSTSTTNTASYPSTLQVATNVPIISLSSCESALGT 197
            ..:|..|..|.||:... .|.|: ..:.|||.|..::|  |.|.:...|.||:.|...|.|:...
Human   318 LNFSDTVGAVCLPAKEQHFPKGSRCWVSGWGHTHPSHT--YSSDMLQDTVVPLFSTQLCNSSCVY 380

  Fly   198 KGSDVHSTNLCTGPLTGGVSICTSDSGGPLV--QGNV--LIGIVSWGKLPCGQANSPSVYVQVSS 258
            .|: :....||.|.|.|....|..|||||||  .|:.  |:|:||||: .|.:.|.|.||.:|:.
Human   381 SGA-LTPRMLCAGYLDGRADACQGDSGGPLVCPDGDTWRLVGVVSWGR-GCAEPNHPGVYAKVAE 443

  Fly   259 FISWISANQQVS 270
            |:.||....|.|
Human   444 FLDWIHDTAQDS 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phae1	NP_001285870.1	Tryp_SPc	35..263	CDD:214473	77/234 (33%)
Phae1	NP_001285870.1	Tryp_SPc	36..266	CDD:238113	78/236 (33%)
TMPRSS5	NP_110397.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		SRCR_2	116..213	CDD:292133	6/24 (25%)
		Tryp_SPc	217..448	CDD:214473	77/234 (33%)
		Tryp_SPc	218..451	CDD:238113	78/236 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433637at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920