DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phae1 and Tmprss6

DIOPT Version :9

Sequence 1:	NP_001285870.1	Gene:	Phae1 / 34637	FlyBaseID:	FBgn0263234	Length:	270	Species:	Drosophila melanogaster
Sequence 2:	NP_082178.2	Gene:	Tmprss6 / 71753	MGIID:	1919003	Length:	811	Species:	Mus musculus

Alignment Length:	257	Identity:	75/257 - (29%)
Similarity:	116/257 - (45%)	Gaps:	24/257 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 CRISGVAIGAPEGRVVGGSPAAVNSAPYAVSMQYGGTHYCAASILNANWLVTAAHCLTNSNQVLG 86
            |.:.|::     .|:|||:.::....|:..|:|..|.|.|..:::...|::|||||....:....
Mouse   568 CGLQGLS-----SRIVGGTVSSEGEWPWQASLQIRGRHICGGALIADRWVITAAHCFQEDSMASP 627

  Fly    87 S--TLVAGSIAVDGTASTTQTRSITYFVINDLYTGGTVPYDIGMIYTPTAFVWSAAVAPVTLP-- 147
            .  |:..|.:..:.......:..::...::..:...:..||:.::......|:||.|.||.||
Mouse   628 KLWTVFLGKMRQNSRWPGEVSFKVSRLFLHPYHEEDSHDYDVALLQLDHPVVYSATVRPVCLPAR 692

  Fly   148 SSGVVPTGTANLYGWGSTSTTNTASYPSTLQVATNVPIISLSSCESALGTKGSDVHSTNLCTGPL 212
            |....|.....:.|||:.......|  :||| ..:|.::....|..|...:   |....||.|..
Mouse   693 SHFFEPGQHCWITGWGAQREGGPVS--NTLQ-KVDVQLVPQDLCSEAYRYQ---VSPRMLCAGYR 751

  Fly   213 TGGVSICTSDSGGPLV----QGN-VLIGIVSWGKLPCGQANSPSVYVQVSSFISWISANQQV 269
            .|....|..|||||||    .|. .|.|:|||| |.||:.|...||.:|:..|:||   |||
Mouse   752 KGKKDACQGDSGGPLVCREPSGRWFLAGLVSWG-LGCGRPNFFGVYTRVTRVINWI---QQV 809

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phae1	NP_001285870.1	Tryp_SPc	35..263	CDD:214473	68/236 (29%)
Phae1	NP_001285870.1	Tryp_SPc	36..266	CDD:238113	69/238 (29%)
Tmprss6	NP_082178.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..48
		SEA	88..185	CDD:279699
		LDLa	459..489	CDD:238060
		LDLa	495..525	CDD:238060
		Ldl_recept_a	529..566	CDD:278486
		Tryp_SPc	576..806	CDD:214473	68/236 (29%)
		Tryp_SPc	577..809	CDD:238113	70/241 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433637at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010