DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phae1 and TMPRSS7

DIOPT Version :9

Sequence 1:	NP_001285870.1	Gene:	Phae1 / 34637	FlyBaseID:	FBgn0263234	Length:	270	Species:	Drosophila melanogaster
Sequence 2:	NP_001382436.1	Gene:	TMPRSS7 / 344805	HGNCID:	30846	Length:	843	Species:	Homo sapiens

Alignment Length:	245	Identity:	80/245 - (32%)
Similarity:	118/245 - (48%)	Gaps:	30/245 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 RVVGGSPAAVNSAPYAVSMQYGGTHYCAASILNANWLVTAAHCLTNSNQVLGSTLVAGSIA--VD 97
            |::||:.......|:.||:.:.|:.||.||:::..||::||||. :.|::...|.....:.  |.
Human   605 RIIGGTDTLEGGWPWQVSLHFVGSAYCGASVISREWLLSAAHCF-HGNRLSDPTPWTAHLGMYVQ 668

  Fly    98 GTAS-TTQTRSITYFVINDLYTGGTVPYDIGMIYTPTAFVW----SAAVAPVTLPSSGV-VPTG- 155
            |.|. .:..|.|   |:::.|...|..|||.::....|  |    ...:.|:.:|.:|. |.:|
Human   669 GNAKFVSPVRRI---VVHEYYNSQTFDYDIALLQLSIA--WPETLKQLIQPICIPPTGQRVRSGE 728

  Fly   156 TANLYGWGST-STTNTASYPSTLQVATNVPIISLSSCESALGTKGSDVHSTNLCTGPLTGGVSIC 219
            ...:.|||.. ...|..|.  .||.| .|.:|..:.|.|..|.    :.|..||.|.::|....|
Human   729 KCWVTGWGRRHEADNKGSL--VLQQA-EVELIDQTLCVSTYGI----ITSRMLCAGIMSGKRDAC 786

  Fly   220 TSDSGGPL-----VQGN-VLIGIVSWGKLPCGQANSPSVYVQVSSFISWI 263
            ..||||||     ..|. :|.||||||. ..|:.|.|.||.:||:|:.||
Human   787 KGDSGGPLSCRRKSDGKWILTGIVSWGH-GSGRPNFPGVYTRVSNFVPWI 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phae1	NP_001285870.1	Tryp_SPc	35..263	CDD:214473	78/243 (32%)
Phae1	NP_001285870.1	Tryp_SPc	36..266	CDD:238113	79/244 (32%)
TMPRSS7	NP_001382436.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..67
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433637at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010