DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Phae1 and PRSS53

DIOPT Version :9

Sequence 1:	NP_001285870.1	Gene:	Phae1 / 34637	FlyBaseID:	FBgn0263234	Length:	270	Species:	Drosophila melanogaster
Sequence 2:	XP_011544118.1	Gene:	PRSS53 / 339105	HGNCID:	34407	Length:	623	Species:	Homo sapiens

Alignment Length:	324	Identity:	70/324 - (21%)
Similarity:	118/324 - (36%)	Gaps:	80/324 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LASGLLLLLGI------CRISGVAIGAP-EGRVVGGSPAAVNSAPYAVSMQYGGTHYCAASILNA 68
            :|...:|:.|:      |...|.....| ||..|.|      ..|:..|::..|.|.|:.|::..
Human    11 IAGATVLMEGLQAAQRACGQRGPGPPKPQEGNTVPG------EWPWQASVRRQGAHICSGSLVAD 69

  Fly    69 NWLVTAAHCLTN--SNQVLGSTLVAGSIAVDGTASTTQTRSITYFVINDLYTGGTVPYDIGMIYT 131
            .|::|||||...  :.::...::|.||:..:|.:...:...:....:...|...:...|:.::..
Human    70 TWVLTAAHCFEKAAATELNSWSVVLGSLQREGLSPGAEEVGVAALQLPRAYNHYSQGSDLALLQL 134

  Fly   132 --PTAFVWSAAVAPVTLP--------SSGVVPTG----TANLYGWGSTSTTNTASYPSTLQVATN 182
              ||..      .|:.||        .:....||    |::...|...........||....|.|
Human   135 AHPTTH------TPLCLPQPAHRFPFGASCWATGWDQDTSDGKCWPRLKLGEALCLPSVTVSAPN 193

  Fly   183 VP--------------------------------IISLSSCESALGTKGSDVHSTN------LCT 209
            .|                                :||..:| :.:..:....|.:|      ||.
Human   194 CPGFQSPLLPRSQTLAPAPSLSPAPGTLRNLRLRLISRPTC-NCIYNQLHQRHLSNPARPGMLCG 257

  Fly   210 GPLTGGVSICTSDSGGPLV----QGN-VLIGIVSWGKLPCGQANSPSVYVQVSSFISWISANQQ 268
            ||..|....|..|||||::    .|: |..||:|:.. .|.|.::|.:....::..||:.|..|
Human   258 GPQPGVQGPCQGDSGGPVLCLEPDGHWVQAGIISFAS-SCAQEDAPVLLTNTAAHSSWLQARVQ 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Phae1	NP_001285870.1	Tryp_SPc	35..263	CDD:214473	59/286 (21%)
Phae1	NP_001285870.1	Tryp_SPc	36..266	CDD:238113	60/288 (21%)
PRSS53	XP_011544118.1	Tryp_SPc	42..316	CDD:238113	60/287 (21%)
		Tryp_SPc	43..314	CDD:214473	58/284 (20%)
		Tryp_SPc	359..>512	CDD:304450
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433637at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920